γ-aminobutyric acid receptor B signaling drives glioblastoma in females in an immune-dependent manner
Defne Bayik,
Asmita Pathak,
Palavalasa Sra
et al.
Abstract:Sex differences in immune responses impact cancer outcomes and treatment response, including in glioblastoma (GBM). However, host factors underlying sex specific immune-cancer interactions are poorly understood. Here, we identify the neurotransmitter γ-aminobutyric acid (GABA) as a driver of GBM-promoting immune response in females. We demonstrated that GABA receptor B (GABBR) signaling enhances L-Arginine metabolism and nitric oxide synthase 2 (NOS2) expression in female granulocytic myeloid-derived suppresso… Show more
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