2021
DOI: 10.1038/s41374-020-00492-3
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βCysteine 93 in human hemoglobin: a gateway to oxidative stability in health and disease

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Cited by 18 publications
(13 citation statements)
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“…Multiple evidence indicates that βCys93 is an important hotspot of free radical-induced oxidation in Hb ( 3 , 30 , 54 ). To study the oxidative modification of cysteines, we examined Hb derived from complicated lesions of carotid arteries with mass spectrometry.…”
Section: Resultsmentioning
confidence: 99%
“…Multiple evidence indicates that βCys93 is an important hotspot of free radical-induced oxidation in Hb ( 3 , 30 , 54 ). To study the oxidative modification of cysteines, we examined Hb derived from complicated lesions of carotid arteries with mass spectrometry.…”
Section: Resultsmentioning
confidence: 99%
“…According to the literature data, the second cysteine of the Hb β-subunit (Cys112β) is located quite far from Cys93β [52], and can hardly be the second amino acid ligand for Hb-DNICs. Such ligands could potentially be His92β, His97β or Asp94β residues located near Cys93β [53].…”
Section: Discussionmentioning
confidence: 99%
“…Hb oxidation is implicated in the pathogenesis of atherosclerotic plaque progression [18], as well as in other hemolytic diseases [11][12][13]44]. Having shown that A1M is induced by the Hb oxidation products heme and FerrylHb, we next examined whether A1M inhibits the process of Hb oxidation.…”
Section: Ra1m Inhibits Hb Oxidationmentioning
confidence: 99%