β2 adrenergic receptors and leptin interplay to decrease food intake in chicken

Zendehdel, Morteza; Khodadadi, Mina; Vosoughi, Ahmad; Mokhtarpouriani, Kasra; Baghbanzadeh, Ali

doi:10.1080/00071668.2019.1704687

Cited by 4 publications

(2 citation statements)

References 72 publications

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“…Currently, the studies on avian leptin mainly focus on the reproductive system in growth and development [ 137 , 138 , 139 ]. In poultry, leptin activates the Janus kinase/signal transducer and activator of transcription (JAK–STAT) signaling pathway and regulates energy homeostasis through bending to the leptin receptor [ 140 ].…”

Section: Molecular Mechanism Of Osteocalcin In Flhs Chickensmentioning

confidence: 99%

Osteocalcin and Its Potential Functions for Preventing Fatty Liver Hemorrhagic Syndrome in Poultry

Zhang

Jiang

et al. 2023

Animals

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Osteocalcin (OCN) is synthesized and secreted by differentiating osteoblasts. In addition to its role in bone, OCN acts as a hormone in the pancreas, liver, muscle, fat, and other organs to regulate multiple pathophysiological processes including glucose homeostasis and adipic acid metabolism. Fat metabolic disorder, such as excessive fat buildup, is related to non-alcoholic fatty liver disease (NAFLD) in humans. Similarly, fatty liver hemorrhage syndrome (FLHS) is a metabolic disease in laying hens, resulting from lipid accumulation in hepatocytes. FLHS affects hen health with significant impact on poultry egg production. Many studies have proposed that OCN has protective function in mammalian NAFLD, but its function in chicken FLHS and related mechanism have not been completely clarified. Recently, we have revealed that OCN prevents laying hens from FLHS through regulating the JNK pathway, and some pathways related to the disease progression have been identified through both in vivo and vitro investigations. In this view, we discussed the current findings for predicting the strategy for using OCN to prevent or reduce FLHS impact on poultry production.

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Section: Molecular Mechanism Of Osteocalcin In Flhs Chickensmentioning

confidence: 99%

Osteocalcin and Its Potential Functions for Preventing Fatty Liver Hemorrhagic Syndrome in Poultry

Zhang

Jiang

et al. 2023

Animals

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“…The inhibitory action of these drugs on eating behavior has been documented to be regulated by activation of brain NE and brain a1-adrenoceptors, and may be attenuated by lesions of the ventral noradrenergic bundle [11]. Conversely, eating may be suppressed by administering a2-adrenoceptor antagonists, such as yohimbine [17,18].…”

Section: The Noradrenergic System and Feeding Behaviormentioning

confidence: 99%

The Role of the Noradrenergic System in Eating Disorders: A Systematic Review

Pruccoli

Parmeggiani

Cordelli

et al. 2021

IJMS

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Noradrenaline (NE) is a catecholamine acting as both a neurotransmitter and a hormone, with relevant effects in modulating feeding behavior and satiety. Several studies have assessed the relationship between the noradrenergic system and Eating Disorders (EDs). This systematic review aims to report the existing literature on the role of the noradrenergic system in the development and treatment of EDs. A total of 35 studies were included. Preclinical studies demonstrated an involvement of the noradrenergic pathways in binge-like behaviors. Genetic studies on polymorphisms in genes coding for NE transporters and regulating enzymes have shown conflicting evidence. Clinical studies have reported non-unanimous evidence for the existence of absolute alterations in plasma NE values in patients with Anorexia Nervosa (AN) and Bulimia Nervosa (BN). Pharmacological studies have documented the efficacy of noradrenaline-modulating therapies in the treatment of BN and Binge Eating Disorder (BED). Insufficient evidence was found concerning the noradrenergic-mediated genetics of BED and BN, and psychopharmacological treatments targeting the noradrenergic system in AN. According to these data, further studies are required to expand the existing knowledge on the noradrenergic system as a potential target for treatments of EDs.

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The Crosstalk Between Brain Mediators Regulating Food Intake Behavior in Birds: A Review

Rahmani

Ghashghayi

Zendehdel

et al. 2021

Int J Pept Res Ther

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Appetite is controlled by a complex system of central and peripheral signals interacting to modulate the ingestion response. Several brain mediators with complex networks adjust food intake in birds. Based on the available literature, these mediators have interactions with a number of other neurotransmitters (NT S ) involved in feed intake. It means that, NT S regulate feeding behavior through mediating other peptide and NTs activity. In birds, insulin known as a hypophagic hormone that is interplaying with neuropeptide Y (NPY), pro-opiomelanocortin (POMC), and corticotropin-releasing factor (CRF) in brain. Another hormone ghrelin, inhibits food intake in birds and other mediators, such as glutamate, endocannabinoid system (ECS), serotonin (5-hydroxytryptamine, 5-HT), and norepinephrine (NE), which play a key role in ghrelin-induced hypophagia. Another involved peptide on feeding behavior in chickens called nociceptin/orphanin FQ (N/OFQ) is modulated by histamine, glutamate, dopamine (DA), gamma-aminobutyric acid (GABA), agouti-related protein (AgRP), and cocaine and amphetamine-regulated transcript (CART). Some of the NT S such as opioid have both orexigenic and anorexigenic effects in birds while has interaction with NE, glutamate, histamine, DA, and cannabinoids (CBs). Thus, interaction among mediators is a prominent process needs to be considered in order to understanding the mechanisms underlying feed intake regulation in birds. This review aims to investigate the role of major regulators and their mediatory interactions with one another in poultry feeding behavior. According to mentioned interactions, it seems that dopamine, serotonin, and glutamate have the most interactions with other NT systems. Therefore, they play an axial role in the central regulation of food intake in CNS.

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β2 adrenergic receptors and leptin interplay to decrease food intake in chicken

Cited by 4 publications

References 72 publications

Osteocalcin and Its Potential Functions for Preventing Fatty Liver Hemorrhagic Syndrome in Poultry

Osteocalcin and Its Potential Functions for Preventing Fatty Liver Hemorrhagic Syndrome in Poultry

The Role of the Noradrenergic System in Eating Disorders: A Systematic Review

The Crosstalk Between Brain Mediators Regulating Food Intake Behavior in Birds: A Review

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