β2-Adrenergic Receptor Genetic Polymorphisms and Short-term Bronchodilator Responses in Patients With COPD

Hizawa, Nobuyuki; Makita, Hironi; Nasuhara, Yasuyuki; Betsuyaku, Tomoko; Itoh, Yoko; Nagai, Katsura; Hasegawa, Masaru; Nishimura, Masaharu

doi:10.1378/chest.07-1103

Cited by 62 publications

(46 citation statements)

References 36 publications

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“…10,11 The role of the ADBR2 polymorphisms in treatment response in COPD is unclear. Some studies suggest an interaction of ADRB2 with acute bronchodilator response in patients with COPD, [12][13][14][15] whereas others have found no effect of ADRB2 polymorphism on acute bronchodilator response in some COPD populations. 15,16 …”

Section: Original Research Copdmentioning

confidence: 99%

ADRB2 Polymorphisms and Budesonide/Formoterol Responses in COPD

Bleecker

Meyers

Bailey

et al. 2012

Chest

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Section: Original Research Copdmentioning

confidence: 99%

ADRB2 Polymorphisms and Budesonide/Formoterol Responses in COPD

Bleecker

Meyers

Bailey

et al. 2012

Chest

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“…Associations with specific ADRB2 polymorphisms may predict response to long acting beta agonists (LABA), inhaled corticosteroids (ICS) and anticholinergics [23,24]. Additionally, the COPD population, including geriatric patients, may be susceptible to such predilection based upon recent studies [25]. Alternatively, a number of studies refute such associations [3,[26][27][28].…”

Section: Discussionmentioning

confidence: 99%

“…Finally, we did not examine specific treatment regimens in the recruited patients. The relationship between ADRB2 polymorphism and different treatment regimens has been well studied during the last decade with mixed results [3][4][5][6]10,[24][25][26][27][28]. As such, there has been no major paradigm shift in treatment of asthma or COPD with respect to varying ADRB2 polymorphisms.…”

Section: Discussionmentioning

confidence: 99%

No Correlation between Beta2-Adrenergic Receptor Polymorphisms and the Severity and Clinical Control of Geriatric Asthma and COPD

Pham¹

2014

J Allergy Ther

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Background: Polymorphisms of the β2-adrenergic receptor (ADRB2) have previously been associated with non-specific bronchial hyper-responsiveness, adverse response to β2-agonists and variable effects on lung function. The objective of this study was to determine whether genotypic variance in ADRB2 polymorphisms in a cohort of geriatric men and women with asthma and/or COPD correlate with disease severity, baseline pulmonary function, and the ability to maintain clinical control of their disease.Methods: This comparative, prospective cohort study sequenced two ADRB2 polymorphisms, Arg16 --> Gly and Gln27 --> Glu, in 103 geriatric patients with a clinical history of asthma and/or COPD. Primary endpoints included pulmonary exacerbation rate, hospitalization rate, and quality of life scores.Results: Arg/Arg genotype comprised 13.6% of the cohort. No significant differences in baseline pulmonary functions were noted across genotypic variants. No significant difference was associated with genotype and change in lung function, exacerbations, clinical hospitalizations, exercise tolerance and subjective quality of life assessment over 6 months of follow-up. Conclusion:We conclude that in a geriatric asthma and/or COPD population, ADRB2 polymorphisms are not a factor in the ability to control disease.

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“…No association was found, except with the BMI, with the parameters studied such as lung function, the GOLD stage, the age and the severity of smoking. Considering that Klotho gene is a metabolic gene, question is raised whether the mechanism of emphysema induction of the Klotho deficient gene is through a possible metabolic path in patients with COPD [46].…”

Section: Klotho Genementioning

confidence: 99%

Genetic Implications in COPD. The Current Knowledge

Sotiriou¹,

Makris²

2013

OJRD

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Chronic Obstructive Pulmonary Disease (COPD) is a multifactorial disease in the pathogenesis of which contributes a variety of causative factors including genetic and environmental ones. They may also be interactions of genetic susceptibilities and environmental influences. Towards to that in the pathogenesis of the disease except smoking, it seems to have a great impact the genetic predisposition of the individuals suffering from that serious progressive disease. Regarding to these observations and findings very interesting studies have been conducted in order to elucidate the implications of different genes, and their polymorphisms in disease aetiology. This is a review which elucidates the impact of genetic susceptibility in COPD.

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β2-Adrenergic Receptor Genetic Polymorphisms and Short-term Bronchodilator Responses in Patients With COPD

Cited by 62 publications

References 36 publications

ADRB2 Polymorphisms and Budesonide/Formoterol Responses in COPD

ADRB2 Polymorphisms and Budesonide/Formoterol Responses in COPD

No Correlation between Beta2-Adrenergic Receptor Polymorphisms and the Severity and Clinical Control of Geriatric Asthma and COPD

Genetic Implications in COPD. The Current Knowledge

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