β2-adrenergic receptor gene polymorphisms and pregnancy outcome

Doh, Kunihiko; Sziller, István; Vardhana, Santosha A.; Kovács, Eszter; Papp, Zoltán; Witkin, Steven S.

doi:10.1515/jpm.2004.138

Cited by 44 publications

(39 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Associations were also found between the ␤ 2 -adrenergic receptor (ADRB2) polymorphisms and preterm labor (20,21). Moreover, Landau et al (22) showed that ADRB2 Arg16 homozygosity improves pregnancy outcome after ␤(2)-agonist tocolysis.…”

Section: Discussionmentioning

confidence: 98%

A Possible Role for the PPARG Pro12Ala Polymorphism in Preterm Birth

et al. 2007

View full text Add to dashboard Cite

The links between preterm birth, low birth weight, and adult vascular/metabolic morbidity remain unclear. Genetic susceptibility of babies related to these three conditions might contribute to this long-term association. We tested whether the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor ␥ (PPARG) gene could play a role in birth weight and duration of gestation. We genotyped two independent cross-sectional studies from Northern Ireland (n ‫؍‬ 382 and 620). In combined populations, the PPARG Ala12 allele was associated (P ‫؍‬ 0.03) with lower birth weight, primarily caused by shorter gestational duration (P ‫؍‬ 0.04). The frequency of Ala12 allele carriers was higher (P ‫؍‬ 0.027) in the group of individuals born before term (35%, n ‫؍‬ 60) than in the group of individuals born at term (22%, n ‫؍‬ 942). The odds ratios (95% CI) of preterm birth for Ala12 allele carriers were 1.9 (1.1-3.4), P ‫؍‬ 0.022, and 4.2 (1.9 -9.7), P ‫؍‬ 0.0006 (adjusted for sex, maternal age, and study), when considering 37 or 35 weeks of pregnancy as a threshold for preterm birth, respectively. Interestingly, the same allele was also associated with a moderate decreased risk of miscarriages in mothers. In conclusion, the PPARG Pro12Ala polymorphism might represent a genetic susceptibility factor for preterm birth and constitute a link between preterm birth and metabolic diseases later in life.

show abstract

Section: Discussionmentioning

confidence: 98%

A Possible Role for the PPARG Pro12Ala Polymorphism in Preterm Birth

et al. 2007

View full text Add to dashboard Cite

show abstract

“…[5][6][7][8] Some observations suggest the existence of a genetic predisposition to PRM and PD, [9][10][11][12][13][14] and several genetic polymorphisms have been proposed as risk factors. [13][14][15][16][17][18][19] Previous studies have investigated the association between reninangiotensin system (RAS) polymorphisms and pregnancy complications, such as stillbirth, abortion, pre-eclampsia, and hypertension. [20][21][22][23][24] Some of these entities are considered risk factors for PD.…”

Section: Introductionmentioning

confidence: 99%

Genetic polymorphisms of the renin-angiotensin system in preterm delivery and premature rupture of membranes

Valdez-Velázquez¹,

Quintero‐Ramos

Pérez

et al. 2007

J Renin Angiotensin Aldosterone Syst

View full text Add to dashboard Cite

Introduction. Premature rupture of membranes (PRM) is a late pregnancy complication commonly associated with preterm delivery (PD).Although several markers related to the renin-angiotensin system (RAS) have been evaluated in certain pregnancy complications, only the angiotensin-converting enzyme (ACE) I/D variant has been studied in PD-PRM.The aim of this survey was to investigate the association of the polymorphisms (angiotensin II type 1 [AT1] receptor T174M and M235T, renin G2805A,ACE I/D and AT1-receptor A1166C) of the genes of RAS in women with PD-PRM. Design. Deoxyribonucleic acid samples from 89 Mexican Mestizo women with PD and PRM and 224—288 controls were studied. Polymorphisms were analysed by polymerase chain reaction-sequence specific primer assays. restricted fragment length polymorphism or sequence specific prim assays. Results. For all loci , genotype distribution was in agreement with Hardy—Weinberg expectations in the control group. Significant intergroup difference (case vs. control) was seen for angiotensinogen (AGT) M235T polymorphism, with an increased allele M235 in affected cases (50% vs. 40% in controls).Analysis of two- locus haplotype agrees with an independent segregation of physically unlinked genes. Haplotype AGT 174T-235M was also increased (50 % vs. 40% in controls). Conclusions. Physically unlinked genes involved in RAS segregate independently. The AGT 174—235 region is associated with PD-PRM in this population.

show abstract

“…Maternal ADRB2 genotype has been investigated in relation to risk for pre-term labor and birth, with the Gly16 51,52 and Glu27 53 alleles being associated with higher risk, whereas autism has been associated with premature birth in some [54][55][56] though not all 57,58 studies. The observed association between Glu27 homozygous genotype and autism, therefore, could possibly be explained by maternal genotype, mediated through prematurity.…”

Section: Discussionmentioning

confidence: 99%

β2-Adrenergic receptor gene variants and risk for autism in the AGRE cohort

et al. 2007

View full text Add to dashboard Cite

The b 2 -adrenergic receptor is part of the catecholamine system, and variants at two polymorphic sites in the gene coding for the receptor (ADRB2) confer increased activity. Overstimulation of this receptor may alter brain development, and has been linked to autism in non-identical twins. The objective of this study was to determine whether alleles in ADRB2 are associated with diagnosis of autism in the Autism Genetic Resource Exchange (AGRE) population. Three hundred and thirty-one independent autism case-parent trios were included in the analysis. Subjects were genotyped at activity-related polymorphisms rs1042713 (codon 16) and rs1042714 (codon 27). Association between autism and genotypes at each polymorphic site was tested using genotype-based transmission disequilibrium tests, and effect modification by family and pregnancy characteristics was evaluated. Sensitivity to designation of the proband in each family was assessed by performing 1000 repeats of the analysis selecting affected children randomly. A statistically significant OR of 1.66 for the Glu27 homozygous genotype was observed. Increased associations with this genotype were observed among a subset of Autism Diagnostic Observation Schedule confirmed cases and a subset reporting experience of pregnancy-related stressors. In conclusion, the Glu27 allele of the ADRB2 gene may confer increased risk of autism and shows increased strength with exposure to pregnancy related stress.

show abstract

β2-adrenergic receptor gene polymorphisms and pregnancy outcome

Abstract: At codon 16 of the beta2-AR gene, maternal Arg-16 homozygosity protects against, and Gly-16 predisposes to spontaneous preterm birth.

Cited by 44 publications

References 20 publications

A Possible Role for the PPARG Pro12Ala Polymorphism in Preterm Birth

A Possible Role for the PPARG Pro12Ala Polymorphism in Preterm Birth

Genetic polymorphisms of the renin-angiotensin system in preterm delivery and premature rupture of membranes

β2-Adrenergic receptor gene variants and risk for autism in the AGRE cohort

Contact Info

Product

Resources

About