2006
DOI: 10.1128/jvi.80.6.2760-2770.2006
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β1 Integrin Mediates Internalization of Mammalian Reovirus

Abstract: Reovirus infection is initiated by interactions between the attachment protein 1 and cell surface carbohydrate and junctional adhesion molecule A (JAM-A). Expression of a JAM-A mutant lacking a cytoplasmic tail in nonpermissive cells conferred full susceptibility to reovirus infection, suggesting that cell surface molecules other than JAM-A mediate viral internalization following attachment. The presence of integrinbinding sequences in reovirus outer capsid protein 2, which serves as the structural base for 1,… Show more

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Cited by 156 publications
(172 citation statements)
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“…3A. Although reovirus particles were observed in the cytoplasm of all cell types, there was a notable decrease in ␤1Ϫ/Ϫ cells, as described previously (34). Surprisingly, reovirus particles were internalized into both ␤1ϩ/ϩ and ␤1ϩ/ϩY783F/Y795F cells (Fig.…”
Section: Resultsmentioning
confidence: 48%
See 1 more Smart Citation
“…3A. Although reovirus particles were observed in the cytoplasm of all cell types, there was a notable decrease in ␤1Ϫ/Ϫ cells, as described previously (34). Surprisingly, reovirus particles were internalized into both ␤1ϩ/ϩ and ␤1ϩ/ϩY783F/Y795F cells (Fig.…”
Section: Resultsmentioning
confidence: 48%
“…All reovirus serotypes bind to proteinaceous receptor junctional adhesion molecule A (JAM-A) to mediate high-affinity attachment (5,14,50). Following receptor binding, reovirus is internalized into cells via a mechanism involving ␤1 integrin (34).…”
mentioning
confidence: 99%
“…Taken together, these observations suggest that birnaviruses may need to interact with two different receptors, one for attachment located at the top of the spike-which may confer also tissue tropism and modulate virulence-and a second receptor for internalization, interacting with the conserved groove. This pattern has parallels in other nonenveloped viruses, such as adenoviruses and reoviruses, in which initial attachment to a specific receptor is followed by interaction with an integrin for internalization (37,49). The bottom line of this study is that, in spite of the detailed knowledge of the architecture of the virus particles described here and elsewhere, understanding the underlying birnavirus biology-its entry process and the mechanism of attenuation and virulence-absolutely requires now the identification of the various host partners used for cell invasion.…”
Section: Vol 84 2010mentioning
confidence: 98%
“…Integrins bind specific ligands in a divalent cation-dependent manner, and a subset of integrins bind to specific recognition sequences such as the amino acid Arg-Gly-Asp (RGD) motif (19). Several viruses use RGD-binding integrins as receptors or co-receptors, including adenovirus (20), echovirus (21), footand-mouth disease virus (22), hantavirus (23), human herpes virus-8 (24), human parechovirus (25), reovirus (26), rotavirus (27), and West Nile virus (28). A role for integrins in infection by any paramyxovirus has not been elucidated.…”
mentioning
confidence: 99%