β-TCP porous pellets as an orthopaedic drug delivery system: ibuprofen/carrier physicochemical interactions

Baradari, Hiba; Damia, Chantal; Dutreih-Colas, Maggy; Champion, Éric; Chulia, Dominique; Viana, Marylène

doi:10.1088/1468-6996/12/5/055008

Cited by 13 publications

(9 citation statements)

References 36 publications

(45 reference statements)

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“…The successful delivery of anti-inflammatories using calcium phosphate particles has been demonstrated by numerous authors [36,59]. The delivery of ibuprofen using β-TCP particles was demonstrated by Baradari et al [59]. Ibuprofen was soak-loaded onto the particles, with the ibuprofen molecules diffusing into the pores by capillarity and remaining trapped there after solvent removal.…”

Section: Drug and Therapeutic Factor Deliverymentioning

confidence: 99%

“…Ibuprofen was rapidly released from the particles, confirming the weak binding affinity between ibuprofen and β-TCP. No structural or chemical modifications were observed from physiochemical characterisation of the ibuprofen-loaded particles indicating that the binding interactions occur through physisorption processes [59].…”

Section: Drug and Therapeutic Factor Deliverymentioning

confidence: 99%

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Calcium Phosphate Nanoparticles for Therapeutic Applications in Bone Regeneration

2019

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Bone injuries and diseases constitute a burden both socially and economically, as the consequences of a lack of effective treatments affect both the patients’ quality of life and the costs on the health systems. This impended need has led the research community’s efforts to establish efficacious bone tissue engineering solutions. There has been a recent focus on the use of biomaterial-based nanoparticles for the delivery of therapeutic factors. Among the biomaterials being considered to date, calcium phosphates have emerged as one of the most promising materials for bone repair applications due to their osteoconductivity, osteoinductivity and their ability to be resorbed in the body. Calcium phosphate nanoparticles have received particular attention as non-viral vectors for gene therapy, as factors such as plasmid DNAs, microRNAs (miRNA) and silencing RNA (siRNAs) can be easily incorporated on their surface. Calcium phosphate nanoparticles loaded with therapeutic factors have also been delivered to the site of bone injury using scaffolds and hydrogels. This review provides an extensive overview of the current state-of-the-art relating to the design and synthesis of calcium phosphate nanoparticles as carriers for therapeutic factors, the mechanisms of therapeutic factors’ loading and release, and their application in bone tissue engineering.

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Section: Drug and Therapeutic Factor Deliverymentioning

confidence: 99%

Section: Drug and Therapeutic Factor Deliverymentioning

confidence: 99%

Calcium Phosphate Nanoparticles for Therapeutic Applications in Bone Regeneration

2019

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“…It was reported that the interaction between porous β-TCP pellets and ibuprofen is weak. In vitro tests showed the complete release (100%) of ibuprofen due to Van der Waals forces [ 355 ]. Xiao and co-workers reported that an asymmetric coating formed from hydroxyapatite and gelatin on a Ti6Al4V alloy implant released ibuprofen for a minimum of 30 days.…”

Section: Resultsmentioning

confidence: 99%

Critical Review of Biodegradable and Bioactive Polymer Composites for Bone Tissue Engineering and Drug Delivery Applications

et al. 2021

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In the determination of the bioavailability of drugs administered orally, the drugs’ solubility and permeability play a crucial role. For absorption of drug molecules and production of a pharmacological response, solubility is an important parameter that defines the concentration of the drug in systemic circulation. It is a challenging task to improve the oral bioavailability of drugs that have poor water solubility. Most drug molecules are either poorly soluble or insoluble in aqueous environments. Polymer nanocomposites are combinations of two or more different materials that possess unique characteristics and are fused together with sufficient energy in such a manner that the resultant material will have the best properties of both materials. These polymeric materials (biodegradable and other naturally bioactive polymers) are comprised of nanosized particles in a composition of other materials. A systematic search was carried out on Web of Science and SCOPUS using different keywords, and 485 records were found. After the screening and eligibility process, 88 journal articles were found to be eligible, and hence selected to be reviewed and analyzed. Biocompatible and biodegradable materials have emerged in the manufacture of therapeutic and pharmacologic devices, such as impermanent implantation and 3D scaffolds for tissue regeneration and biomedical applications. Substantial effort has been made in the usage of bio-based polymers for potential pharmacologic and biomedical purposes, including targeted deliveries and drug carriers for regulated drug release. These implementations necessitate unique physicochemical and pharmacokinetic, microbiological, metabolic, and degradation characteristics of the materials in order to provide prolific therapeutic treatments. As a result, a broadly diverse spectrum of natural or artificially synthesized polymers capable of enzymatic hydrolysis, hydrolyzing, or enzyme decomposition are being explored for biomedical purposes. This summary examines the contemporary status of biodegradable naturally and synthetically derived polymers for biomedical fields, such as tissue engineering, regenerative medicine, bioengineering, targeted drug discovery and delivery, implantation, and wound repair and healing. This review presents an insight into a number of the commonly used tissue engineering applications, including drug delivery carrier systems, demonstrated in the recent findings. Due to the inherent remarkable properties of biodegradable and bioactive polymers, such as their antimicrobial, antitumor, anti-inflammatory, and anticancer activities, certain materials have gained significant interest in recent years. These systems are also actively being researched to improve therapeutic activity and mitigate adverse consequences. In this article, we also present the main drug delivery systems reported in the literature and the main methods available to impregnate the polymeric scaffolds with drugs, their properties, and their respective benefits for tissue engineering.

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“…5a-c). The brown-yellow color was ascribed to β-TCP [25][26][27][28][29][30][31][32] ( Fig. 5b) while the darker was linked to the mixture of NiTi substrate, TiO 2 thin film [32,34] and phosphate groups [25][26][27][28][29][30][31][32] (Fig.…”

Section: Resultsmentioning

confidence: 99%

Multifunctional layers formation on the surface of NiTi SMA during β-tricalcium phosphate deposition

et al. 2015

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β-TCP porous pellets as an orthopaedic drug delivery system: ibuprofen/carrier physicochemical interactions

Cited by 13 publications

References 36 publications

Calcium Phosphate Nanoparticles for Therapeutic Applications in Bone Regeneration

Calcium Phosphate Nanoparticles for Therapeutic Applications in Bone Regeneration

Critical Review of Biodegradable and Bioactive Polymer Composites for Bone Tissue Engineering and Drug Delivery Applications

Multifunctional layers formation on the surface of NiTi SMA during β-tricalcium phosphate deposition

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