β ₂ -Glycoprotein I/IgA Immune Complexes

Abstract

The presence of B2A-CIC is a predictor of acute thrombotic events. Patients who were positive for IgA aB2GP1 only are at risk of experiencing thrombosis if they are B2A-CIC positive. If they are B2A-CIC-negative patients, they have the same risk as the control group. Treatments to prevent acute thrombotic events should focus on B2A-CIC-positive patients.

Immune Complexes of Beta-2-Glycoprotein I and IgA Antiphospholipid Antibodies Identify Patients With Elevated Risk of Thrombosis and Early Mortality After Heart Transplantation

“…This work confirms and validates the described previously conclusion with kidney transplant patients that the presence of B2A-CIC in patients positive for IgA aB2GPI is associated with thrombotic risk. It also confirms the observation that patients positive for IgA aB2GPI who are negative for B2A-CIChave the same risk of developing APS events as patients who are negative for anti-B2GP1 antibodies (24). Mortality and development of thrombotic events after transplantation are multifactorial processes involving several risk factors present mainly before transplantation and also others that arise after transplantation (such as multiple surgery, mechanical support and infections).…”

“…These situations behave as enhancers of thrombotic activity (post-transplant risk factors). The incidence of TRB-D events in the first trimester in patients without these post-transplant risk factors is very similar to that observed in the first trimester in renal transplants: B2A-CIC negative barely distinguish themselves from the control group (24). However, in patients where these factors are present, although the incidence of TRB-D events in the B2A-CIC positive is still significantly higher, the incidence of TRB-B triples in group-0 and quadruples in group-2.…”

“…In patients who will undergo a kidney transplant, the pretransplant presence of B2A-CIC helps to identify which patients with antiphospholipid antibodies have high risk of developing thrombosis in the first 6 months after kidney transplantation. Patients positive for IgA aB2GP1 who were negative for B2A-CIC had a thrombosis risk similar to the general population (24).…”

Pretransplant IgA-Anti-Beta 2 Glycoprotein I Antibodies As a Predictor of Early Graft Thrombosis after Renal Transplantation in the Clinical Practice: A Multicenter and Prospective Study

“…Since not all IgA-aB2GP1 positive patients develop thrombotic complications ( 18 ), the next step should be to find a marker that would identify the patients with a higher risk of thrombosis among those are IgA-aB2GP1 positive ( 28 ). We recently described that the presence of circulating immune complexes (CIC) of IgA bounded to B2GP1 was associated with occurrence of recent thrombotic events ( 29 ) and are a predictor of acute thrombotic events, including graft thrombosis after renal transplantation ( 30 ). However, we have not been able to detect the presence of CIC as, unfortunately, although the conditions of preservation of serum samples were adequate for the determination of IgA-aB2GP1, these conditions were not consistent with the maintenance of stable CIC and they had not been reliably determined in the present group of patients in some centers.…”

Comparative Proteomic Investigation of Plasma Reveals Novel Potential Biomarker Groups for Acute Aortic Dissection

“…The B2-GP1 is a phospholipid-binding glycoprotein and was reported to be involved in the immune system by directly interacting with membrane Toll-like receptors, resulting in activation of endothelial cells and monocytes and expression of proinflammatory cytokines [46]. The B2-GP1 also has been reported as a potential biomarker for predicting thrombosis after renal transplantation [47]. CPN1 was also reported to be useful in early detection of breast cancer [48].…”