β-Resorcylic acid derivatives with α-glucosidase inhibitory activity from Lasiodiplodia sp. ZJ-HQ1, an endophytic fungus in the medicinal plant Acanthus ilicifolius

Chen, Senhua; Liu, Zhaoming; Li, Hanxiang; Xia, Guoping; Lü, Yongjun; He, Lei; Huang, Shao Dong; She, Zhigang

doi:10.1016/j.phytol.2015.05.019

Cited by 31 publications

(13 citation statements)

References 25 publications

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“…Some lasiodiplodins with α-glucosidase inhibitory activity had been reported [34], so the α-glucosidase inhibitory effects of the isolated compounds were evaluated. As a result (Table 3), compounds 4 , 5 , 8 , 9 , and 10 exhibited potent α-glucosidase inhibitory activity with IC 50 of 25.8, 54.6, 64.2, 48.9, and 60.3 µM, respectively, which were much better than acarbose (IC 50 of 703.8 µM) as a positive control.…”

Section: Resultsmentioning

confidence: 99%

Induction of Diverse Bioactive Secondary Metabolites from the Mangrove Endophytic Fungus Trichoderma sp. (Strain 307) by Co-Cultivation with Acinetobacter johnsonii (Strain B2)

et al. 2017

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Two new sesquiterpenes, microsphaeropsisin B (1) and C (2), and two new de-O-methyllasiodiplodins, (3R, 7R)-7-hydroxy-de-O-methyllasiodiplodin (4) and (3R)-5-oxo-de-O-methyllasiodiplodin (5), together with one new natural product (6) and twelve known compounds (3, 7–17), were isolated from the co-cultivation of mangrove endophytic fungus Trichoderma sp. 307 and aquatic pathogenic bacterium Acinetobacter johnsonii B2. Their structures, including absolute configurations, were elucidated by extensive analysis of spectroscopic data, electronic circular dichroism, Mo2(AcO)4-induced circular dichroism, and comparison with reported data. All of the isolated compounds were tested for their α-glucosidase inhibitory activity and cytotoxicity. New compounds 4 and 5 exhibited potent α-glucosidase inhibitory activity with IC50 values of 25.8 and 54.6 µM, respectively, which were more potent than the positive control (acarbose, IC50 = 703.8 µM). The good results of the tested bioactivity allowed us to explore α-glucosidase inhibitors in lasiodiplodins.

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Section: Resultsmentioning

confidence: 99%

Induction of Diverse Bioactive Secondary Metabolites from the Mangrove Endophytic Fungus Trichoderma sp. (Strain 307) by Co-Cultivation with Acinetobacter johnsonii (Strain B2)

et al. 2017

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“…Lasiodiplodia species exhibit diverse life-styles as endophytes 8,15 , pathogens 3,16 and saprobes 3,17 . Lasiodiplodia species with endophytic life-styles are associated with different asymptomatic plant tissues such as L .…”

Section: Discussionmentioning

confidence: 99%

“…Species of Lasiodiplodia are cosmopolitan in tropical and subtropical regions and occur on a wide range of monocotyledonous, dicotyledonous and gymnosperm hosts 2,3,6,8,13 . They exhibit diverse life-styles as endophytes, inhabiting different asymptomatic plant tissues 8,14,15 , pathogens that cause diseases in various plant hosts 3,16 and saprobes that are commonly found on dead woody plant tissues 3,17 .…”

Section: Introductionmentioning

confidence: 99%

Phylogeny and morphology of Lasiodiplodia species associated with Magnolia forest plants

Silva

Phillips

Liu

et al. 2019

Sci Rep

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Two new species of Lasiodiplodia (Lasiodiplodia endophytica and Lasiodiplodia magnoliae) are described and illustrated from Magnolia forests in Yunnan, China. Endophytic and saprobic Lasiodiplodia pseudotheobromae and endophytic L. thailandica are new records from this host. The internal transcribed spacers (ITS), part of the translation elongation factor-1α (tef1) and partial β-tubulin (tub2) sequence data were analyzed to investigate the phylogenetic relationships of the new species with other Lasiodiplodia species. Lasiodiplodia magnoliae is phylogenetically sister to L. mahajangana and L. pandanicola but morphologically distinct from L. mahajangana in having larger conidia. Lasiodiplodia endophytica is most closely related to L. iraniensis and L. thailandica and the three species can be distinguished from one another by 2 base pair differences in ITS and three or four base pair differences in tef1. The new collections suggest that Magnolia forest plants are good hosts for Lasiodiplodia species with endophytic and saprobic life-styles.

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“…A sample of 15 (1.0 mg, 4 μmol), ( R )-MPTACl (5.0 μL, 25 μmol) and pyridine- d 5 (0.5 mL) were used to react in an NMR tube at room temperature for 24 h, with the 1 H NMR data of the ( S )-MTPA ester derivative ( 15a ) were obtained directly on the reaction mixture [21,22]. 1 H NMR (selected signals, pyridine- d 5 , 400 MHz) δ H : 7.21 (1H, d, H-13), 6.42 (1H, dd, H-14), 5.95 (1H, q, H-15), 1.85 (2H, m, H-16).…”

Section: Methodsmentioning

confidence: 99%

Anti-Inflammatory Cembrane-Type Diterpenoids and Prostaglandins from Soft Coral Lobophytum sarcophytoides

et al. 2019

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Two new cembrane-type diterpenoids, lobophytins A (1) and B (3), and four new prostaglandins, (5E)-PGB2 (10), (5E)-13,14-dihydro-PGB2 (11), 13,14-dihydro-PGB2 (12) and 13,14-dihydro-PGB2-Me (13), together with ten known compounds were isolated from the soft coral Lobophytum sarcophytoides. The structures of these new secondary metabolites were identified by high resolution mass spectrometry (HR-ESIMS), nuclear magnetic resonance (NMR) and electron circular dichroism (ECD) analyses, as well as the modified Mosher’s method. Compounds 6, 7, 9, 10, 12, 13, 15 and 16 showed potential anti-inflammatory activity by inhibiting the production of nitric oxide (NO) in RAW264.7 cells that were activated by lipopolysaccharide, with IC50 values ranging from 7.1 to 32.1 μM and were better than the positive control indomethacin, IC50 = 39.8 μM.

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β-Resorcylic acid derivatives with α-glucosidase inhibitory activity from Lasiodiplodia sp. ZJ-HQ1, an endophytic fungus in the medicinal plant Acanthus ilicifolius

Cited by 31 publications

References 25 publications

Induction of Diverse Bioactive Secondary Metabolites from the Mangrove Endophytic Fungus Trichoderma sp. (Strain 307) by Co-Cultivation with Acinetobacter johnsonii (Strain B2)

Induction of Diverse Bioactive Secondary Metabolites from the Mangrove Endophytic Fungus Trichoderma sp. (Strain 307) by Co-Cultivation with Acinetobacter johnsonii (Strain B2)

Phylogeny and morphology of Lasiodiplodia species associated with Magnolia forest plants

Anti-Inflammatory Cembrane-Type Diterpenoids and Prostaglandins from Soft Coral Lobophytum sarcophytoides

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