β-Papillomaviruses and psoriasis: an intra-patient comparison of human papillomavirus carriage in skin and hair

Cronin, James G.; Mesher, David; Purdie, Karin J.; Evans, Harry L.; Breuer, Judith; Harwood, Catherine A.; McGregor, Jane; Proby, Charlotte M.

doi:10.1111/j.1365-2133.2008.08627.x

Cited by 37 publications

(28 citation statements)

References 32 publications

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“…We observed no association with whole-body actinic keratoses in those with the long-term persistent βPV infections. The association between βPV persistence and actinic keratoses on the head and neck but not with actinic keratoses on the whole body might indicate that βPV in eyebrow hairs is a better marker of infection on the face, neck, and scalp than on the rest of the body, despite a recent study showing that eyebrow hairs are a good marker of cutaneous infection on the body (5,(28)(29)(30). Previous studies of the association between actinic keratosis and βPV did not examine head and neck actinic keratosis in isolation; therefore, comparisons cannot be made.…”

Section: Discussionmentioning

confidence: 71%

Persistence of Betapapillomavirus Infections as a Risk Factor for Actinic Keratoses, Precursor to Cutaneous Squamous Cell Carcinoma

et al. 2009

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Human papillomaviruses from the β genus (βPV) are a possible cause of cutaneous squamous cell carcinoma (SCC). We assessed the extent to which βPV infections persisted longterm in a subtropical Australian community and whether βPV persistence is positively associated with actinic keratoses, precursor for SCC. Eyebrow hairs were collected from 171 participants of the community-based Nambour Skin Cancer Study in 1996 and 2003. Hair samples were tested for the presence of DNA from 25 different βPV types and assessed in relation to actinic keratosis presence in 2007. In 1996, a total of 413 βPV infections were found in 73% of participants, increasing to 490 infections among 85% in 2003. Of the total βPV infections detected, 211 (30%) were found to persist. Age was significantly associated with βPV persistence: those ages >60 years had 1.5-fold (95% confidence interval, 1.1-1.9) increased risk of typespecific viral persistence than those ages <40 years. After accounting for actinic keratoses at baseline, persistence of βPV DNA resulted in a 1.4-fold (95% confidence interval, 1.0-1.9) increase in risk of having actinic keratoses on the face in 2007. In conclusion, persistent βPV infections in this population were associated with an increased occurrence of actinic keratosis. Additional studies are needed to determine the possible association of βPV persistence with SCC. [Cancer Res 2009;69(23):8926-31]

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Section: Discussionmentioning

confidence: 71%

Persistence of Betapapillomavirus Infections as a Risk Factor for Actinic Keratoses, Precursor to Cutaneous Squamous Cell Carcinoma

et al. 2009

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“…55 (37) 76 ( 23 (16) 45 (25) 1.9 (1.1-3.4) a BetaPV DNA in eyebrow hairs has been used as an indicator of skin infection at the site of the lesion, and 2 studies have suggested that the former is indeed a reasonable proxy despite some degree of misclassification (37,41). However, the highly sensitive laboratory test used may result in ascertainment of infections that are present at very low copy number or are only transient.…”

Section: Discussionmentioning

confidence: 99%

Multicenter Study of the Association between Betapapillomavirus Infection and Cutaneous Squamous Cell Carcinoma

et al. 2010

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Human papillomaviruses (betaPV) from the beta genus cannot be classified according to their oncogenicity due to a paucity of information. This study evaluates the association between betaPV infection and cutaneous squamous cell carcinoma in conjunction with measures of UV exposure and susceptibility. We performed casecontrol studies in the Netherlands, Italy, and Australia, countries with profoundly different UV exposures. The presence of 25 betaPV types in eyebrow hair follicles was determined using a highly sensitive HPV DNA genotyping assay, and antibodies for the 15 most prevalent betaPV types in a total of 689 squamous cell carcinoma cases and 845 controls were detected using multiplex serology. Multivariate logistic regression models were used for case-control comparisons and interaction analyses. BetaPV DNA was detected in eyebrow hairs of more than 90% of all participants. The presence of betaPV DNA was associated with an increased risk of squamous cell carcinoma in the Netherlands (OR ¼ 2.8; 95% CI 1.3-5.8) and Italy (OR ¼ 1.7; 95% CI 0.79-3.6), but not in Australia (OR ¼ 0.91; 95% CI 0.53-1.6). Seropositivity for betaPV in controls ranged between 52% and 67%. A positive antibody response against 4 or more betaPV types was associated with squamous cell carcinoma in Australia (OR ¼ 2.2; 95% CI 1.4-3.3), the Netherlands (OR ¼ 2.0; 95% CI 1.2-3.4) and fair-skinned Italians (OR ¼ 1.6, 95% CI 0.94-2.7). The association between UV susceptibility and squamous cell carcinoma was stronger in betaPV-seropositive people. These combined data support the hypothesis that betaPV may play a role in the development of cutaneous squamous cell carcinoma. Cancer Res; 70(23); 9777-86. Ó2010 AACR.

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“…Other authors have not been able to establish a link between CMV or human herpes viruses (HHV) 6 and 7 infections and a subsequent development of psoriasis [21]. HPV subtypes 5 and 36 are also pathogenic candidates, although their precise contribution remains to be clarified [22]. Three publications reported guttate psoriasis following varicella [13][14][15].…”

Section: Discussionmentioning

confidence: 99%

Childhood Herpes Zoster-Triggered Guttate Psoriasis

Failla

Nikkels‐Tassoudji

Sabatiello

et al. 2012

TODJ

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Psoriasis is commonly triggered or exacerbated by various stress factors, certain drugs, or streptococcal throat infections. Viral infections such as HIV, CMV, chikungunya, or herpes simplex virus are very uncommon triggers for psoriasis. Cases of varicella-triggered psoriasis are exceptional. A 7-year-old boy with a previous history of guttate psoriasis presented with generalized acute guttate psoriasis shortly after an extensive herpes zoster infection affecting the first and second left lumbar dermatomes. INF-alpha and granulocyte monocyte colony stimulating factor influence peripheral monocytes to transform into INF-dendritic cells (DC's), similar to those involved in psoriasis. These INF-DC's express toll-like receptors 7 and 8, which are responsive to viral single stranded RNA. Hence, viral infections and interferon (INF)-alpha may play a role in triggering psoriasis.A PubMed search revealed no previous reports of herpes zoster triggered acute guttate psoriasis in children.

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β-Papillomaviruses and psoriasis: an intra-patient comparison of human papillomavirus carriage in skin and hair

Cited by 37 publications

References 32 publications

Persistence of Betapapillomavirus Infections as a Risk Factor for Actinic Keratoses, Precursor to Cutaneous Squamous Cell Carcinoma

Persistence of Betapapillomavirus Infections as a Risk Factor for Actinic Keratoses, Precursor to Cutaneous Squamous Cell Carcinoma

Multicenter Study of the Association between Betapapillomavirus Infection and Cutaneous Squamous Cell Carcinoma

Childhood Herpes Zoster-Triggered Guttate Psoriasis

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