β-NaGdF<sub>4</sub>:Eu<sup>3+</sup> nanocrystal markers for melanoma tumor imaging

Sojka, Bartlomiej; Podhorodecki, A.; Bański, Mateusz; Misiewicz, J.; Drobczyński, Sławomir; Dumych, Tetiana; Lutsyk, M. M.; Lutsyk, А. D.; Bilyy, Rostyslav

doi:10.1039/c6ra10351k

Cited by 9 publications

(2 citation statements)

References 49 publications

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“…We assume that this phenomenon is connected with an increase in the distance between Yb 3+ and Er 3+ ions after the shell growth and the reduction in number of Yb 3+ ions coupled to Er 3+ ions due to Yb 3+ ions diffusing out from the core to the shell region. A similar effect was already reported by Voß et al [37] and also found in our group for β-NaGdF 4 :Eu 3+ core-shell samples [38]. Hence we can conclude that for the core-shell structures the excitation mechanism is changing and seems to be the same as in the case of the ions distributed homogenously in big NCs.…”

Section: (B))supporting

confidence: 90%

Size and shape effects in β-NaGdF₄: Yb³⁺, Er³⁺ nanocrystals

Noculak

Podhorodecki²

2017

Nanotechnology

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Three sets of β-NaGdF:Yb, Er nanocrystals (NCs) with different shapes (spherical and more complex flower shapes), different sizes (6-17 nm) and Yb concentrations (2%-15%) were synthesized by a co-precipitation method using oleic acid as a stabilizing agent. The uncommon, single-crystalline flower-shaped NCs were obtained by simply adjusting the fluorine-to-lanthanides molar ratio. Additionally, some of the NCs with different sizes have been covered by the un-doped shell. The crystal phase, shapes and sizes of all NCs were examined using transmission electron microscopy and x-ray diffraction methods. Simultaneously, upconversion luminescence and lifetimes, under 980 nm excitation, were measured and the changes in green to red (G/R) emission ratios as well as emission decay times were correlated with the evolution of nanocrystal sizes and surface to volume ratios. Three different mechanisms responsible for the changes in G/R ratios were presented and discussed.

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Section: (B))supporting

confidence: 90%

Size and shape effects in β-NaGdF₄: Yb³⁺, Er³⁺ nanocrystals

Noculak

Podhorodecki²

2017

Nanotechnology

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“…Development of upconverting nanocrystals (UPNCs) paved a new path to the many new practical implementations. The unique optical properties of UPNCs such as anti-Stokes, multiband emission, long-time luminescence decay, narrow emission bands, and the absence of photobleaching make them attractive materials for bioimaging. − Moreover, the efficiency of the upconversion process in UPNCs is a few orders of magnitude higher compared to that in popular two-photon fluorophores. , Recently, UPNCs were used in optogenetics to locally activate biological photoreactive molecules to control neural activity. − On the contrary to the colloidal semiconducting quantum dots, UPNCs do not exhibit quantum size effect and their optical properties only weakly depend on UPNC surface changes . Therefore, the nanocrystals of a size ranging from 5 to 200 nm may have the same photoluminescence peak position, with significantly different mobility in liquid media.…”

Section: Introductionmentioning

confidence: 99%

Single-Nanocrystal Studies on the Homogeneity of the Optical Properties of NaYF₄:Yb³⁺,Er³⁺

et al. 2020

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Development of upconverting nanomaterials which are able to emit visible light upon near-infrared excitation opens a wide range of potential applications. Because of their remarkable photostability, they are widely used in bioimaging, optogenetics, and optoelectronics. In this work, we demonstrate the influence of several experimental conditions as well as a dopant concentration on the luminescence properties of upconverting nanocrystals (UPNCs) that need to be taken into account for their efficient use in the practical applications. We found that not only nanoparticle architecture affects the optical properties of UPNCs, but also factors such as sample concentration, excitation light power density, and temperature may influence the green-to-red emission ratio. We performed studies on both the single-nanoparticle and ensemble levels over a broad concentration range and found the heterogeneity in the optical properties of UPNCs with low dopant concentrations.

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Effects of surface functionalization of hydrophilic NaYF4 nanocrystals doped with Eu3+ on glutamate and GABA transport in brain synaptosomes

et al. 2017

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Specific rare earth doped nanocrystals (NCs), a recent class of nanoparticles with fluorescent features, have great bioanalytical potential. Neuroactive properties of NaYF4 nanocrystals doped with Eu3+ were assessed based on the analysis of their effects on glutamate- and γ-aminobutyric acid (GABA) transport process in nerve terminals isolated from rat brain (synaptosomes). Two types of hydrophilic NCs were examined in this work: (i) coated by polyethylene glycol (PEG) and (ii) with OH groups at the surface. It was found that NaYF4:Eu3+-PEG and NaYF4:Eu3+-OH within the concentration range of 0.5–3.5 and 0.5–1.5 mg/ml, respectively, did not influence Na+-dependent transporter-dependent l-[14C]glutamate and [3H]GABA uptake and the ambient level of the neurotransmitters in the synaptosomes. An increase in NaYF4:Eu3+-PEG and NaYF4:Eu3+-OH concentrations up to 7.5 and 3.5 mg/ml, respectively, led to the (1) attenuation of the initial velocity of uptake of l-[14C]glutamate and [3H]GABA and (2) elevation of ambient neurotransmitters in the suspension of nerve terminals. In the mentioned concentrations, nanocrystals did not influence acidification of synaptic vesicles that was shown with pH-sensitive fluorescent dye acridine orange, however, decreased the potential of the plasma membrane of synaptosomes. In comparison with other nanoparticles studied with similar methodological approach, NCs start to exhibit their effects on neurotransmitter transport at concentrations several times higher than those shown for carbon dots, detonation nanodiamonds and an iron storage protein ferritin, whose activity can be registered at 0.08, 0.5 and 0.08 mg/ml, respectively. Therefore, NCs can be considered lesser neurotoxic as compared to above nanoparticles.

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β-NaGdF₄:Eu³⁺ nanocrystal markers for melanoma tumor imaging

Abstract: Europium doped nanocrystals can be optimized to be successfully used as visualization markers for i.e. melanoma tumor.

Cited by 9 publications

References 49 publications

Size and shape effects in β-NaGdF₄: Yb³⁺, Er³⁺ nanocrystals

Size and shape effects in β-NaGdF₄: Yb³⁺, Er³⁺ nanocrystals

Single-Nanocrystal Studies on the Homogeneity of the Optical Properties of NaYF₄:Yb³⁺,Er³⁺

Effects of surface functionalization of hydrophilic NaYF4 nanocrystals doped with Eu3+ on glutamate and GABA transport in brain synaptosomes

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β-NaGdF4:Eu3+ nanocrystal markers for melanoma tumor imaging

Abstract: Europium doped nanocrystals can be optimized to be successfully used as visualization markers for i.e. melanoma tumor.

Cited by 9 publications

References 49 publications

Size and shape effects in β-NaGdF4: Yb3+, Er3+ nanocrystals

Size and shape effects in β-NaGdF4: Yb3+, Er3+ nanocrystals

Single-Nanocrystal Studies on the Homogeneity of the Optical Properties of NaYF4:Yb3+,Er3+

Effects of surface functionalization of hydrophilic NaYF4 nanocrystals doped with Eu3+ on glutamate and GABA transport in brain synaptosomes

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β-NaGdF₄:Eu³⁺ nanocrystal markers for melanoma tumor imaging

Size and shape effects in β-NaGdF₄: Yb³⁺, Er³⁺ nanocrystals

Size and shape effects in β-NaGdF₄: Yb³⁺, Er³⁺ nanocrystals

Single-Nanocrystal Studies on the Homogeneity of the Optical Properties of NaYF₄:Yb³⁺,Er³⁺