β‐lactamase producing bacteria in the subgingival microflora of adult patients with periodontitis. A comparison between Spain and The Netherlands

Abstract

A high prevalence of beta-lactamase producing bacteria has been evaluated in two distinct populations, belonging to two European countries with clear differences in antibiotic usage policy. A higher prevalence and a more complex beta-lactamase producing microflora, were found in the Spanish group, associated with a higher antibiotic consumption. This study shows that a higher use of beta-lactam antibiotics is reflected in the % of beta-lactamase producing bacteria in the subgingival microflora of patients with periodontitis. This information may be important in the treatment of severe periodontitis.

Evaluationof the Mandibular Third Molar Pericoronitis Flora and ItsSusceptibility to Different Antibiotics PrescribedinFrance

“…Therapeutic management usually involves a local surgical procedure and the prescription of antibiotics, often of the ␤-lactam family (7). The frequency of antibioticresistant microorganisms is dependent on the populations and is related to the prescribing habits of practitioners in each country (9,25). In a previous study with selective media, we demonstrated the presence of ␤-lactamase-producing bacteria in 9 out of 26 French patients suffering from pericoronitis (23).…”

Microbiology and Treatment of Acute Apical Abscesses

“…Kuriyama et al (221) revealed that beta-lactamase was detected in 36% of the dark-pigmented Prevotella and 32% of the nonpigmented Prevotella species isolated from pus samples of oral abscesses. Other enzyme-producing oral anaerobic species include strains of the Gram-negative bacteria F. nucleatum, E. corrodens, and T. forsythia and the Gram-positive bacteria P. acnes, Actinomyces species, and Peptostreptococcus species (98,(217)(218)(219)(221)(222)(223). Bacteria that produce beta-lactamases not only may protect themselves from penicillins but also can protect other penicillinsusceptible bacteria present in a mixed community by releasing free beta-lactamase into the environment (224).…”

Antibiotic Resistance in Bacteria Isolated from Subgingival Plaque in a Norwegian Population with Refractory Marginal Periodontitis

“…However, superinfecting organisms such as enteric gram-negative rods, pseudomonads, staphylococci, and yeasts have been isolated from refractory periodontitis lesions (22), as well as taxa not considered a common part of the oral microbiota (5). There are reports of increasing ␤-lactamase production in subgingival periodontal pathogens in several countries (7,12,17,27). In Norway, however, this situation has not been studied.…”