β-Lactam Resistance Gene NDM-1 in the Aquatic Environment: A Review

Ranjan, Rajeev; Thatikonda, Shashidhar

doi:10.1007/s00284-021-02630-6

Cited by 14 publications

(14 citation statements)

References 97 publications

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“…Additionally, ARB and ARGs are widespread in aquaculture farms, highlighting a great threat to humans and aquatic organisms ( Harnisz et al, 2015 ; Ranjan and Thatikonda, 2021 ). The diversity of ARGs in the intestinal bacteria of shrimp was investigated by polymerase chain reaction (PCR) and metagenomic analysis ( Liu et al, 2019 ).…”

Section: Bacterial Resistance To Antibiotics In Food Animal Farmsmentioning

confidence: 99%

A Review of Current Bacterial Resistance to Antibiotics in Food Animals

Kong

Gao

et al. 2022

Front. Microbiol.

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The overuse of antibiotics in food animals has led to the development of bacterial resistance and the widespread of resistant bacteria in the world. Antibiotic-resistant bacteria (ARB) and antibiotic-resistant genes (ARGs) in food animals are currently considered emerging contaminants, which are a serious threat to public health globally. The current situation of ARB and ARGs from food animal farms, manure, and the wastewater was firstly covered in this review. Potential risks to public health were also highlighted, as well as strategies (including novel technologies, alternatives, and administration) to fight against bacterial resistance. This review can provide an avenue for further research, development, and application of novel antibacterial agents to reduce the adverse effects of antibiotic resistance in food animal farms.

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Section: Bacterial Resistance To Antibiotics In Food Animal Farmsmentioning

confidence: 99%

A Review of Current Bacterial Resistance to Antibiotics in Food Animals

Kong

Gao

et al. 2022

Front. Microbiol.

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“…Since then, NDM-type carbapenemases have triggered global attention due to their rapid epidemiologic expansion among Enterobacterales and Acinetobacter spp., and more rarely, in Pseudomonas aeruginosa (Dortet et al, 2014). Of note, recent reports have documented the spreading of NDM producers beyond the boundary of human healthcare settings where they were originally related (Ranjan and Thatikonda, 2021). The environmental spread of NDM-producing bacteria has been associated to several human activities that result in chemical and microbial pollution mostly in aquatic environments (Ranjan and Thatikonda, 2021).…”

Section: Resultsmentioning

confidence: 99%

“…Of note, recent reports have documented the spreading of NDM producers beyond the boundary of human healthcare settings where they were originally related (Ranjan and Thatikonda, 2021). The environmental spread of NDM-producing bacteria has been associated to several human activities that result in chemical and microbial pollution mostly in aquatic environments (Ranjan and Thatikonda, 2021).…”

Section: Resultsmentioning

confidence: 99%

“…Particularly, the emergence of metallo-β-lactamase NDM-1-producing bacteria has been a phenomenon of global interest (Nordmann et al, 2011a,b;Dortet et al, 2014). Of epidemiological concern, although the successful spread of plasmids encoding bla NDM -type genes has been primarily related to nosocomial settings (Wu et al, 2019), there is growing evidence of their occurrence beyond the human medicine context (Mills and Lee, 2019;Ranjan and Thatikonda, 2021). Indeed, NDM-1-producing bacteria have been increasingly reported in environmental samples (mostly in anthropogenic-impacted aquatic environments) (Ranjan and Thatikonda, 2021).…”

Section: Introductionmentioning

confidence: 99%

“…Of epidemiological concern, although the successful spread of plasmids encoding bla NDM -type genes has been primarily related to nosocomial settings (Wu et al, 2019), there is growing evidence of their occurrence beyond the human medicine context (Mills and Lee, 2019;Ranjan and Thatikonda, 2021). Indeed, NDM-1-producing bacteria have been increasingly reported in environmental samples (mostly in anthropogenic-impacted aquatic environments) (Ranjan and Thatikonda, 2021). More critically, NDM-1-positive bacteria have begun to be documented in wild animals (Fischer et al, 2013;Liao et al, 2019;Mairi et al, 2020), which could indicate, in part, that these criticalpriority bacteria can spill over into natural ecosystems, and then further spread in wildlife (Dolejska and Literak, 2019;Mills and Lee, 2019;Cohen et al, 2020;Mairi et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

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Genomic Analysis of a Highly Virulent NDM-1-Producing Escherichia coli ST162 Infecting a Pygmy Sperm Whale (Kogia breviceps) in South America

et al. 2022

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Carbapenemase-producing Enterobacterales are rapidly spreading and adapting to different environments beyond hospital settings. During COVID-19 lockdown, a carbapenem-resistant NDM-1-positive Escherichia coli isolate (BA01 strain) was recovered from a pygmy sperm whale (Kogia breviceps), which was found stranded on the southern coast of Brazil. BA01 strain belonged to the global sequence type (ST) 162 and carried the blaNDM–1, besides other medically important antimicrobial resistance genes. Additionally, genes associated with resistance to heavy metals, biocides, and glyphosate were also detected. Halophilic behavior (tolerance to > 10% NaCl) of BA01 strain was confirmed by tolerance tests of NaCl minimal inhibitory concentration, whereas halotolerance associated genes katE and nhaA, which encodes for catalase and Na+/H+ antiporter cytoplasmic membrane, respectively, were in silico confirmed. Phylogenomics clustered BA01 with poultry- and human-associated ST162 lineages circulating in European and Asian countries. Important virulence genes, including the astA (a gene encoding an enterotoxin associated with human and animal infections) were detected, whereas in vivo experiments using the Galleria mellonella infection model confirmed the virulent behavior of the BA01 strain. WHO critical priority carbapenemase-producing pathogens in coastal water are an emerging threat that deserves the urgent need to assess the role of the aquatic environment in its global epidemiology.

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