β-Lactam and penicillin substituted mesoionic metal carbene complexes

Abstract

1,2,3-Triazolylidene MIC M-complexes (M = Au, Pd, Pt) having 2-azetidinones and penicillin G substituents at triazole ring were prepared by CuAAC on 2-azetidinones having a terminal alkyne tethered at N1,...

Attaching Metal-Containing Moieties to β-Lactam Antibiotics: The Case of Penicillin and Cephalosporin

“…Other work placed several chromium(0) carbene moieties in groups attached to the carboxy or amino moieties of the cepham and penam systems . Very recently, we incorporated mesoionic carbene (MIC) ligands bearing 2-azetidinone, penam, and cepham moieties into Au­(I), Ni­(II), and Pd­(II) complexes 6 and determined their catalytic activity in several cycloisomerizations, hydrosilylations, and Suzuki couplings …”

“… 21 Very recently, we incorporated mesoionic carbene (MIC) ligands bearing 2-azetidinone, penam, and cepham moieties into Au(I), Ni(II), and Pd(II) complexes 6 and determined their catalytic activity in several cycloisomerizations, hydrosilylations, and Suzuki couplings. 22 …”