Source of material 1-(Thiophen-2-yl)-2-tosylethan-1-one waspreparedbythe reaction of 2-bromo-1-(thiophen-2-yl)ethan-1-one with sodium 4-tolylsulfinate.N ext, ther eaction of 1-(thiophen-2-yl)-2-tosylethan-1-one with 4-anisaldehyde, in the presence of piperidine, afforded the title compound in 77% yield. The IR revealed the absorption band of ac arbonyl function at 1665 cm -1 while its 1 HNMR exhibited the signal of -CH= group at d =8.01 in addition to the singlet signals of methyl and methoxyprotons at d = 2.40and 3.74, respectively.
DiscussionThere are great interests in the chemistry and biological activity of thiophenederivativesasthe thiophenemoiety is an important domain in alarge number of biologically active structures [1][2][3][4], and it is also awell-known isostere for benzene ring [5].Onthe other hand, sulfones received aspecial interest in organic chemistry for their ambivalent nature and due to their versatile reactivity in organic synthesis [6, 7]. In addition, b-keto sulfones have gained wide applications as starting materials in the synthesis of several important compounds [8][9][10].Incontinuation of our interests in the chemistry and biologically activity of sulfone and sulfonamide derivatives [11][12][13][14][15][16], we report herein the synthesis and X-ray single crystal analyses of the title compound. Fortunately,wehavesucceeded to getsinglecrystals of thetitle compoundand were able to assign its(E)-configuration. Thecrystal structure contains onem olecule in the asymmetric unit. The E isomerofthe title compound is the kinetically favored candidate. The double bond of C6=C7 is characterized by the distance of 1.334 (4) Å. Themolecules packing in the crystal structure is stabilized by two weak intermolecular interactions, with O3 and O4 as hydrogen bond acceptors and C3 and C19 as hydrogen bond donor. The distance of the interactions between H3A×××O3 is 2.4400(11) Å, H19A×××O4 is 2.4700(9) Åa nd the angles C3-H3A×××O3 is 123.00(4)°, C19-H19A×××O4 is 166.00(7)°. Z. Kristallogr.