β-hydroxybutyrate levels in peripheral blood and ketone bodies supplemented in culture media affect the in vitro chemotaxis of bovine leukocytes

Suriyasathaporn, Witaya; Daemen, A.J.J.M.; Noordhuizen-Stassen, E.N.; Dieleman, S.J.; Nielen, M.; Schukken, Y.H.

doi:10.1016/s0165-2427(99)00017-3

Cited by 129 publications

(105 citation statements)

References 20 publications

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“…These results are in agreement with studies of NEB in humans in whom the chemotactic capacity and the random migration of PMN from short-period NEB are not different in comparison with non-NEB subjects [8,38]. However, cows with spontaneous postpartum NEB, in which it is assumed that the NEB occurs over several weeks, have impaired chemotactic functions of leukocytes [107,108]. This is in agreement with a study on chemotaxis in NEB humans with 90 days of strenuous exercise and caloric deficiency.…”

Section: Capacity Of Blood Leukocytes To Migrate Into the Infected Glandsupporting

confidence: 88%

“…Impairment of leukocyte chemotaxis has also been demonstrated in leukocytes acting in a ketone body environment [108]. Leukocytes in cultures supplemented with BHB, AcAc, acetone, and their mixture show less chemotactic capacity than leukocytes in the control culture.…”

Section: Capacity Of Blood Leukocytes To Migrate Into the Infected Glandmentioning

confidence: 99%

“…The relationship between NEB, ketone bodies and chemotaxis of blood PMN has been investigated [8,37,56,64,107,108]. Sera from NEB humans with urinary ketosis inhibit leukocyte chemotactic response in vitro [64].…”

Section: Capacity Of Blood Leukocytes To Migrate Into the Infected Glandmentioning

confidence: 99%

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Hyperketonemia and the impairment of udder defense: a review

et al. 2000

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-The objective of this study was to review the possible relationships between hyperketonemia and the function of phagocytes with respect to the bovine udder defense mechanism. We hypothesize that an increased incidence of clinical mastitis in high-producing cows is caused by the impairment of the udder defense mechanism during hyperketonemia. First, we review the acute phase of udder defense mechanisms after intramammary infection. The physiological changes of cows in negative energy balance are subsequently discussed. Finally, possible relationships between udder defense and physiological changes during negative energy balance, especially hyperketonemia, are reviewed. The three stages of an acute phase of udder defense are: (1) immediately eliminating invading pathogens by phagocytes, (2) releasing inflammatory substances, especially chemoattractants, and (3) migration of polymorphonuclear leukocytes into the infected udder. Leukocytes from hyperketonemia subjects show a lower capacity of the phagocytic defense mechanism. In addition, the phagocytic and bactericidal capacities of neutrophils are reduced when these cells are acting in the presence of high concentrations of ketone bodies. Lower amounts of cytokine production after bacterial infection are observed in ketotic subjects. The chemotactic capacity of blood leukocytes is impaired in leukocytes obtained from ketotic cows. Lower numbers of blood leukocytes are observed in ketotic cows. In conclusion, the impairment of the udder defense mechanism in negative energy balance cows seems related to hyperketonemia. ketosis / negative energy balance / mastitis / udder defense mechanism / cow Résumé -Hypercétonémie et diminution des défenses mammaires : une synthèse. L'objectif de cette étude est de présenter des relations possibles entre l'hypercétonémie et la fonction des phagocytes pour ce qui est des mécanismes de défense de la mamelle. Notre hypothèse est qu'une Vet. Res. 31 (2000) 397-412 397

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Section: Capacity Of Blood Leukocytes To Migrate Into the Infected Glandsupporting

confidence: 88%

Section: Capacity Of Blood Leukocytes To Migrate Into the Infected Glandmentioning

confidence: 99%

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Hyperketonemia and the impairment of udder defense: a review

et al. 2000

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“…After initiation of the inflammatory response, PMN become the predominant cell type observed during an infection. PMN migrate from the blood to the location of the invading organism by a process called chemotaxis (Suriyasathaporn et al, 1999). Once at the site of infection, PMN and resident macrophages phagocytose, that is, engulf, and kill invading microorganisms (Paape et al, 1991).…”

Section: General Aspects Of the Immune Responsementioning

confidence: 99%

“…Several studies have identified potential mechanisms associated with the impairment of the cellular immune function by increased media concentrations of ketones (Franklin et al, 1991;Detilleux et al, 1995). Chemotactic capabilities (Suriyasathaporn et al, 1999) and respiratory burst activity (Hoeben et al, 1997) are reduced in bovine blood PMN when supplemented with BHBA in vitro. Furthermore, Sartorelli et al (1999) observed an inhibition of ovine PMN superoxide anion production, whereas acetoacetate had minimal effects on PMN function indicating that only the ketone body BHBA may impair the immune function during the transition period and periods of PI.…”

Section: Ketonesmentioning

confidence: 99%

Nutrition, immune function and health of dairy cattle

Ingvartsen

Moyes

2013

Animal

254

214

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The large increase in milk yield and the structural changes in the dairy industry have caused major changes in the housing, feeding and management of the dairy cow. However, while large improvements have occurred in production and efficiency, the disease incidence, based on veterinary records, does not seem to be improved. Earlier reviews have covered critical periods such as the transition period in the cow and its influence on health and immune function, the interplay between the endocrine system and the immune system and nutrition and immune function. Knowledge on these topics is crucial for our understanding of disease risk and our effort to develop health and welfare improving strategies, including proactive management for preventing diseases and reducing the severity of diseases. To build onto this the main purpose of this review will therefore be on the effect of physiological imbalance (PI) on immune function, and to give perspectives for prevention of diseases in the dairy cow through nutrition. To a large extent, the health problems during the periparturient period relate to cows having difficulty in adapting to the nutrient needs for lactation. This may result in PI, a situation where the regulatory mechanisms are insufficient for the animals to function optimally leading to a high risk of a complex of digestive, metabolic and infectious problems. The risk of infectious diseases will be increased if the immune competence is reduced. Nutrition plays a pivotal role in the immune response and the effect of nutrition may be directly through nutrients or indirectly by metabolites, for example, in situations with PI. This review discusses the complex relationships between metabolic status and immune function and how these complex interactions increase the risk of disease during early lactation. A special focus will be placed on the major energetic fuels currently known to be used by immune cells (i.e. glucose, non-esterified fatty acids, beta-hydroxybutyrate and glutamine) and how certain metabolic states, such as degree of negative energy balance and risk of PI, contribute to immunosuppression during the periparturient period. Finally, we will address some issues on disease prevention through nutrition.

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Effect of Environment on Immune Functions

Lacetera¹

2012

Environmental Physiology of Livestock

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β-hydroxybutyrate levels in peripheral blood and ketone bodies supplemented in culture media affect the in vitro chemotaxis of bovine leukocytes

Cited by 129 publications

References 20 publications

Hyperketonemia and the impairment of udder defense: a review

Hyperketonemia and the impairment of udder defense: a review

Nutrition, immune function and health of dairy cattle

Effect of Environment on Immune Functions

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