β-Hydroxy-β-Methylbutyrate (HMB) Supplementation Does Not Affect Changes in Strength or Body Composition during Resistance Training in Trained Men

Slater, G J; Jenkins, David G.; Logan, Peter A.; Lee, Hamilton; Vukovich, Matthew D.; Rathmacher, John A.; Hahn, Allan G.

doi:10.1123/ijsnem.11.3.384

Cited by 111 publications

(93 citation statements)

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“…These results repeated in Thomson et al 22 study in trained men after 9 weeks resistance training. But these findings are not supported by several investigations 8,9,16,24,27,28 .…”

Section: Discussioncontrasting

confidence: 50%

“…It has been suggested that HMB supplementation with 1.5 to 3 g per day reduces muscle proteolysis and increases strength and muscle mass after 3-8 weeks strength training 6,7 . However, these findings aren't confirmed by other studies 8,9 .…”

Section: Introductioncontrasting

confidence: 55%

“…It has been suggested that the HMB effect on body composition is inconsequential 23 .Some studies reported that HMB was unable to change the body composition of athletes involved in resistance training (22), water polo, rowing 9 or football 17,24 .On the other hand, a number of studies failed to confirm these results and indicated that HMB supplementation during 2-to 12-weeks of training promoted significantly greater changes in FFM and fat loss in trained and untrained men and women 4,5,25,26 . Based on previous studies, the data about the effect of HMB supplementation on body composition is inconsistent.…”

Section: Discussionmentioning

confidence: 99%

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Resistance training & beta-hydroxy-beta-methylbutyrate supplementation on hormones

Arazi

Rohani²,

Ghiasi

et al. 2015

Rev Bras Med Esporte

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RESUMOIntroduction: In recent years, there was an increased interest on the effects of beta-hydroxy-beta-methylbutyrate (HMB) supplementation on skeletal muscle due to its anti-catabolic effects. Objectives: To investigate the effect of HMB supplementation on body composition, muscular strength and anabolic-catabolic hormones after resistance training. Methods: Twenty amateur male athletes were randomly assigned to supplement and control groups in a double-blind crossover design and participated in four weeks resistance training. Before and after the test period fasting blood samples were obtained to determine anabolic (the growth hormone and testosterone) and catabolic (cortisol) hormones, and fat mass, lean body mass (LBM) and muscular strength were measured. Dependent and independent t-tests were used to analyze data. Results: After the training period, there were no significant differences between the groups with respect to fat mass, LBM and anabolic-catabolic hormones. HMB supplementation resulted in a significantly greater strength gain (p≤0.05). Conclusion: Greater increase in strength for HMB group was not accompanied by body composition and basal circulating anabolic-catabolic hormonal changes. It seems that HMB supplementation may have beneficial effects on neurological adaptations of strength gain.Keywords: resistance training, hormones, body composition, dietary supplements, HMB, muscle strength. ABSTRACT Introduçao: Nos últimos anos, houve um aumento no interesse sobre os efeitos da suplementação de beta-hidroxi--beta-metilbutirato (HMB) no

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“…These results repeated in Thomson et al 22 study in trained men after 9 weeks resistance training. But these findings are not supported by several investigations 8,9,16,24,27,28 .…”

Section: Discussioncontrasting

confidence: 50%

Section: Introductioncontrasting

confidence: 55%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Resistance training & beta-hydroxy-beta-methylbutyrate supplementation on hormones

Arazi

Rohani²,

Ghiasi

et al. 2015

Rev Bras Med Esporte

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show abstract

“…The low effectiveness of HMB in strength‐trained athletes could be due to the suppression of the proteolysis that is induced by the adaptation to training, which may blunt the effects of HMB 51. Other studies suggest that a longer pre‐exercise supplementation period may be necessary 47.…”

Section: Hmb As a Nutritional Supplementmentioning

confidence: 99%

Beta‐hydroxy‐beta‐methylbutyrate supplementation and skeletal muscle in healthy and muscle‐wasting conditions

Holeček

2017

J cachexia sarcopenia muscle

190

154

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Beta‐hydroxy‐beta‐methylbutyrate (HMB) is a metabolite of the essential amino acid leucine that has been reported to have anabolic effects on protein metabolism. The aims of this article were to summarize the results of studies of the effects of HMB on skeletal muscle and to examine the evidence for the rationale to use HMB as a nutritional supplement to exert beneficial effects on muscle mass and function in various conditions of health and disease.The data presented here indicate that the beneficial effects of HMB have been well characterized in strength‐power and endurance exercise. HMB attenuates exercise‐induced muscle damage and enhances muscle hypertrophy and strength, aerobic performance, resistance to fatigue, and regenerative capacity. HMB is particularly effective in untrained individuals who are exposed to strenuous exercise and in trained individuals who are exposed to periods of high physical stress. The low effectiveness of HMB in strength‐trained athletes could be due to the suppression of the proteolysis that is induced by the adaptation to training, which may blunt the effects of HMB. Studies performed with older people have demonstrated that HMB can attenuate the development of sarcopenia in elderly subjects and that the optimal effects of HMB on muscle growth and strength occur when it is combined with exercise. Studies performed under in vitro conditions and in various animal models suggest that HMB may be effective in treatment of muscle wasting in various forms of cachexia. However, there are few clinical reports of the effects of HMB on muscle wasting in cachexia; in addition, most of these studies evaluated the therapeutic potential of combinations of various agents. Therefore, it has not been possible to determine whether HMB was effective or if there was a synergistic effect. Although most of the endogenous HMB is produced in the liver, there are no reports regarding the levels and the effects of HMB supplementation in subjects with liver disease. Several studies have suggested that anabolic effects of HMB supplementation on skeletal muscle do not occur in healthy, non‐exercising subjects.It is concluded that (i) HMB may be applied to enhance increases in the mass and strength of skeletal muscles in subjects who exercise and in the elderly and (ii) studies examining the effects of HMB administered alone are needed to obtain conclusions regarding the specific effectiveness in attenuating muscle wasting in various muscle‐wasting disorders.

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“…Em um estudo randomizado e duplo-cego, Slater et al 34 avaliaram, durante seis semanas, possíveis mudanças em força e composição corporal de atletas de pólo aquático e remo divididos nos grupos placebo e 3,0g de HMB. Todos os sujeitos participaram de um programa de treinamento contra-resistência 2-3 vezes por semana, constando de 3-5 séries com 4-6 repetições.…”

Section: Efeitos Do Hmb Em Indivíduos Treinados Em Atividade Contra-runclassified

Efeitos da suplementação de b-hidroxi-b-metilbutirato sobre a força e a hipertrofia

Álvares

Meirelles

2008

Rev. Nutr.

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Efeitos da suplementação de β-hidroxi-β-metilbutirato sobre a força e a hipertrofia Effects of β-hydroxy-β-methylbutyrate supplementation on strength and hypertrophyThiago da Silveira ALVARES 1 Cláudia de Mello MEIRELLES 1,2,3 R E S U M OO β-hidroxi-β-metilbutirato é um metabólito da leucina estudado devido aos seus efeitos anticatabólicos e possíveis implicações sobre os ganhos de força e massa muscular associados ao treinamento contra--resistência (conhecido como musculação). O objetivo deste trabalho foi revisar a literatura referente à suplementação de β-hidroxi-β-metilbutirato e os seus efeitos sobre força e hipertrofia em adultos jovens e idosos iniciantes ou treinados em treinamento contra-resistência. Estudos em indivíduos iniciando um programa de treinamento contra-resistência sugerem que a suplementação diária de 1,5 a 3,0g de β-hidroxi-β-metilbutirato pode trazer benefício ergogênico durante as primeiras quatro ou cinco semanas. Entretanto, à medida que o programa de treinamento evolui, tais efeitos não permanecem e os ganhos de força e massa muscular são proporcionados apenas pelo treinamento contra-resistência. Em indivíduos treinados, os resultados parecem não ser os mesmos, uma vez que, desde o início da suplementação, o β-hidroxi-β-metilbutirato não demonstra qualquer benefício adicional aos induzidos pelo treinamento contra-resistência. Alguns efeitos do β-hidroxi-β-metilbutirato na redução do colesterol total e lipoproteína de baixa densidade também foram observados, porém, devido às poucas evidências, não há recomendações para tal finalidade. Nenhum efeito adverso da suplementação foi observado, sendo, aparentemente, segura, contudo a maioria dos estudos foi realizada em curto prazo (menos de 4 semanas) e em indivíduos destreinados. Assim, mais estudos são necessários para esclarecer o mecanismo fisiológico por meio do qual o β-hidroxi-β-metilbutirato exerce seus efeitos anticatabólicos em destreinados e para observar possíveis efeitos adversos.

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β-Hydroxy-β-Methylbutyrate (HMB) Supplementation Does Not Affect Changes in Strength or Body Composition during Resistance Training in Trained Men

Cited by 111 publications

References 0 publications

Resistance training & beta-hydroxy-beta-methylbutyrate supplementation on hormones

Resistance training & beta-hydroxy-beta-methylbutyrate supplementation on hormones

Beta‐hydroxy‐beta‐methylbutyrate supplementation and skeletal muscle in healthy and muscle‐wasting conditions

Efeitos da suplementação de b-hidroxi-b-metilbutirato sobre a força e a hipertrofia

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