β-hexachlorocyclohexane as a Risk for Alzheimer’s Disease: A Pilot Study in North Indian Population

Chhillar, Neelam; Singh, Navneet; Banerjee, B. D.; Bala, Kiran; Sharma, Deepika; Mustafa, Muhammad; Mitrabasu,

doi:10.7726/ajad.2013.1004-2

Cited by 2 publications

(2 citation statements)

References 25 publications

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“…Further, Se and zinc deficiency are found in the AD patients as compared to the agematched controls [41,42]. Organochlorines and organophosphates [43], paraquat [44], fipronil [45], pyrithroid [46] etc. are critical in degenerative CNS disorders and induce oxidative stress in development of AD pathogenesis.…”

Section: Toxicants and Oxidative Stress In Admentioning

confidence: 92%

Toxic Exposure and Life Style Factors on Ageing Brain Neurodegenerative Disease, Alzheimer’s and Parkinson’s: Role of Natural Antioxidants to Ameliorate the Condition

Naha¹,

Das²,

Banerjee³

2018

J Alcohol Drug Depend

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Toxic exposure is a major risk factor for many neurodegenerative diseases in ageing brain such as, Alzheimer's (AD) and Parkinson's (PD), where decline of biological activities in cellular microenvironment render the organism more susceptible to either endogenous or exogenous stressors especially free radical damage, leading to pathological conditions. PCBs, MPTP, organochlorines and organophosphates, paraquat, fipronil, pyrithroid, quinines, and metals like, lead, cadmium, chromium, cobalt, manganese, arsenic etc. are play the crucial role in age-related diseases, AD and PD. Further, the degree of changes in the ageing brain in these cases not only depends on toxic exposures and genetic susceptibility but also on food habit, life style (use of alcohol, smoking, caffeine), environment etc. Certain antioxidants through diet can improve scenario of ageing brain and modulate specific molecular signalling. Therefore, this review briefly discusses the current status of the toxic exposure and life styles on ageing brain neurodegenerative diseases especially, AD and PD, and throws a light on the disease management through natural antioxidant supplements. For this purpose, data were searched through PubMed, MedLine, ResearchGate and Google using several combinations of terms pertaining to different aspects of oxidative modification in ageing brain, exposure of several toxicants and life style factors, AD and PD as well as natural antioxidants.

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Section: Toxicants and Oxidative Stress In Admentioning

confidence: 92%

Toxic Exposure and Life Style Factors on Ageing Brain Neurodegenerative Disease, Alzheimer’s and Parkinson’s: Role of Natural Antioxidants to Ameliorate the Condition

Naha¹,

Das²,

Banerjee³

2018

J Alcohol Drug Depend

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“…[108][109][110][111][112][113], pesticides (organochlorine and organophosphate insecticides: β-hexachlorocyclohexane, dieldrin, etc.) [114][115][116][117][118][119], industrial pollutants (flame retardants, BPA, phthalates, . .…”

Section: Neurodegenerative Disordersmentioning

confidence: 99%

Is the Exposome Involved in Brain Disorders through the Serotoninergic System?

Sarrouilhe¹,

Defamie

Mesnil

2021

Biomedicines

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Serotonin (5-hydroxytryptamine, 5-HT) is a biogenic monoamine acting as a neurotransmitter in the central nervous system (CNS), local mediator in the gut, and vasoactive agent in the blood. It has been linked to a variety of CNS functions and is implicated in many CNS and psychiatric disorders. The high comorbidity between some neuropathies can be partially understood by the fact that these diseases share a common etiology involving the serotoninergic system. In addition to its well-known functions, serotonin has been shown to be a mitogenic factor for a wide range of normal and tumor cells, including glioma cells, in vitro. The developing CNS of fetus and newborn is particularly susceptible to the deleterious effects of neurotoxic substances in our environment, and perinatal exposure could result in the later development of diseases, a hypothesis known as the developmental origin of health and disease. Some of these substances affect the serotoninergic system and could therefore be the source of a silent pandemic of neurodevelopmental toxicity. This review presents the available data that are contributing to the appreciation of the effects of the exposome on the serotoninergic system and their potential link with brain pathologies (neurodevelopmental, neurodegenerative, neurobehavioral disorders, and glioblastoma).

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β-hexachlorocyclohexane as a Risk for Alzheimer’s Disease: A Pilot Study in North Indian Population

Cited by 2 publications

References 25 publications

Toxic Exposure and Life Style Factors on Ageing Brain Neurodegenerative Disease, Alzheimer’s and Parkinson’s: Role of Natural Antioxidants to Ameliorate the Condition

Toxic Exposure and Life Style Factors on Ageing Brain Neurodegenerative Disease, Alzheimer’s and Parkinson’s: Role of Natural Antioxidants to Ameliorate the Condition

Is the Exposome Involved in Brain Disorders through the Serotoninergic System?

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