β-glucan suppresses cell death of ASC deficient macrophages invaded by periodontopathic bacteria through the caspase-11 pathway

Inoue, Maki; Okinaga, Toshinori; Usui, Michihiko; Kawano, Aki; Thongsiri, Chuencheewit; Nakashima, Keisuke; Ariyoshi, Wataru; Nishihara, Tatsuji

doi:10.1093/femsle/fnz093

Cited by 5 publications

(3 citation statements)

References 33 publications

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“…[ 63,64 ] Lastly, the most novel role for dectin‐1 involving trained immunity has been described for the regulation of cell death in murine macrophages and dendritic cells, where CARD9 has the dual role of enhancing TLR signaling through MAP kinase activation and directly promoting NF‐κB activation. [ 19,65–67 ]…”

Section: β‐Glucans As Immunomodulators: Mechanism Of Actionmentioning

confidence: 99%

β‐1,3/1,6‐Glucans and Immunity: State of the Art and Future Directions

Castro

Calder

Roche

2020

Molecular Nutrition Food Res

100

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The innate immune system responds in a rapid and non‐specific manner against immunologic threats; inflammation is part of this response. This is followed by a slower but targeted and specific response termed the adaptive or acquired immune response. There is emerging evidence that dietary components, including yeast‐derived β‐glucans, can aid host defense against pathogens by modulating inflammatory and antimicrobial activity of neutrophils and macrophages. Innate immune training refers to a newly recognized phenomenon wherein compounds may “train” innate immune cells, such that monocyte and macrophage precursor biology is altered to mount a more effective immunological response. Although various human studies have been carried out, much uncertainty still exists and further studies are required to fully elucidate the relationship between β‐glucan supplementation and human immune function. This review offers an up‐to‐date report on yeast‐derived β‐glucans as immunomodulators, including a brief overview of the current paradigm regarding the interaction of β‐glucans with the immune system. The recent pre‐clinical work that has partly decrypted mode of action and the newest evidence from human trials are also reviewed. According to pre‐clinical studies, β‐1,3/1,6‐glucan derived from baker's yeast may offer increased immuno‐surveillance, although the human evidence is weaker than that gained from pre‐clinical studies.

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Section: β‐Glucans As Immunomodulators: Mechanism Of Actionmentioning

confidence: 99%

β‐1,3/1,6‐Glucans and Immunity: State of the Art and Future Directions

Castro

Calder

Roche

2020

Molecular Nutrition Food Res

100

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“…The binding between dectin-1 and β-glucans results in the activation and recruitment of spleen tyrosine kinase (Syk). As a result, NFAT- and NF-κB-induced transcription induces cytokine and chemokine production [ 6 , 79 - 81 ]. Dectin-1 mRNA is widely expressed in several tissues, of which many are also expressed in monocytes of livers and a lungs [ 71 , 82 , 83 ].In the present study, the administration of 500 mg of Euglena /kg B.W.…”

Section: Discussionmentioning

confidence: 99%

Immunoenhancing Effects ofEuglena gracilison a Cyclophosphamide-Induced Immunosuppressive Mouse Model

Yang

Choi

Kim

et al. 2022

J. Microbiol. Biotechnol.

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In this study, the effects of the immune stimulator Euglena gracilis (Euglena) in cyclophosphamide (CCP)-induced immunocompromised mice were assessed. The key component β-1,3-glucan (paramylon) constitutes 50% of E. gracilis. Mice were orally administered Euglena powder (250 and 500 mg/kg body weight (B.W.)) or β-glucan powder (250 mg/kg B.W.) for 19 days. In a preliminary immunology experiment, ICR mice were intraperitoneally injected with 80 mg of CCP/kg B.W. during the final 3 consecutive days. In the main experiment, BALB/c mice were treated with CCP for the final 5 days. To evaluate the enhancing effects of Euglena on the immune system, mouse B.W., the spleen index, natural killer (NK) cell activity and mRNA expression in splenocytes lungs and livers were determined. To detect cytokine and receptor expression, splenocytes were treated with 5 μg/ml concanavalin A or 1 μg/ml lipopolysaccharide. The B.W. and spleen index were significantly increased and NK cell activity was slightly enhanced in all the experimental groups compared to the CCP-only group. In splenocytes, the gene expression levels of tumor necrosis factor-α, interferon-γ, interleukin (IL)-10, IL-6, and IL-12 receptor were increased in the E. gracilis and β-glucan groups compared to the CCP-only group, but there was no significant difference. Treatment with 500 mg of Euglena/kg B.W. significantly upregulated dectin-1 mRNA expression in the lung and liver compared to the CCP-only group. These results suggest that Euglena may enhance the immune system by strengthening innate immunity through immunosuppression.

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“…They are considered to be the “front-line fighters” of the body's immune system, but invasion by germs or viruses is likely to cause apoptosis of macrophages, resulting in impaired immunity. Fermentum β-polysaccharide can bind to the Dectin-1 receptor and down-regulate the cell death induced by the invasion of macrophages by actinomycetes, ensuring the proper functioning of the body's immune system ( Inoue et al, 2019 ). It was shown that both water-soluble and granular β-polysaccharides recognize the Dectin-1 receptor, but that granular β-polysaccharides bind to the Dectin-1 receptor to better trigger the production of pro-inflammatory cytokines.…”

Section: Activitymentioning

confidence: 99%