β-glucan protects against burn-induced oxidative organ damage in rats

Toklu, Hale Z.; Şener, Göksel; Jahovic, Nermina; Uslu, Bahar; Arbak, Serap; Yeğen, Berrak Ç.

doi:10.1016/j.intimp.2005.07.016

Cited by 89 publications

(63 citation statements)

References 58 publications

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“…Liver is not only a major source of inflammatory mediator cytokines and free radicals but is also a target organ for their damaging effect (6,19). The oxygen and nitrogen-based reactants contribute to the activation of lipid peroxidation, protein oxidation and DNA damage in the liver after burns when its antioxidant defense is reduced (26). This mechanism involves NF-kB induction leading to cytokine-induced inflammation (24,25).…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, hepatocytes are much more sensitive to TNF-a damaging effect when their antioxidant capacity is low. TNF-a plays an important role in the occurrence and development of hepatic and cardiac injury in experimental models of thermal trauma (7,26,27). We proved an elevated hepatic TNF-a level accompanied by an increased hepatic NF-KB expression in the burned group.…”

Section: Discussionmentioning

confidence: 99%

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Melatonin Protection against Burn-Induced Hepatic Injury by Down-Regulation and Nuclear Factor Kappa B Activation

Bekyarova

Apostolova

Kotzev

2012

Int J Immunopathol Pharmacol

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Melatonin exhibits a wide variety of biological activity including antioxidant and anti-inflammatory effects. We have previously reported its protective effect on hepatic oxidative hepatic injury in burns. In this study, we investigated the role of nuclear factor kappa B (NF-kB) in melatonin-mediated protection against liver injury by using the burned-rat model. Melatonin (N-acetyl-5-methoxytriptamin, 10mgl kg (-1), Lp.) was administered immediately and 12 hours after thermal skin injury. Hepatic NF-kB expression was determined by Western blotting. TNF-a level in liver homogenate was quantified using enzyme-linked immunosorbent assay (ELISA) kit. Plasma aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels were determined to assess liver injury at the 24 th hour after burns. Thermal skin injury caused significant elevation of hepatic NF-kB expression by 48%, TNF-a level by 55% and plasma AST and ALT activities by 2-and 3-fold, respectively, in comparison with normal control rats. Treatment with melatonin decreased significantly elevated hepatic NF-kB activity and TNF-a, maintaining the levels close to the control values Melatonin suppressed the elevation of plasma AST and ALT activities (p

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Melatonin Protection against Burn-Induced Hepatic Injury by Down-Regulation and Nuclear Factor Kappa B Activation

Bekyarova

Apostolova

Kotzev

2012

Int J Immunopathol Pharmacol

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“…Beta glukanın sepsis, yanık gibi durumlarda ortaya çıkan karaciğer hasarını ve MDA seviyesini azalttığını bildiren yayınlar vardır. [27,28] Beta glukanın ayrıca, başka dokulardaki hasarı ve MDA düzeylerini de azalttığı belirlenmiştir. [12] Çalışmamız-da, TS nedeniyle gelişen MDA ve LPO seviyelerindeki artışın, beta glukan tedavisi ile önlendiği görülmek-tedir.…”

Section: Discussionunclassified

Effects of beta-glucan on hepatic damage caused by obstructive jaundice

Erkol

Kahramansoy²,

Kordon³

et al. 2011

Ulus Travma Acil Cerrahi Derg

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“…-glucans are acknowledged to be one of the immune response modifiers [6]. Studies conducted over the past decade have shown that -glucans inhibit tumor development [28,38], enhance defense against bacterial infection [15,24], activate macrophages [8], induce production of cytokines [10,34], nitric oxide (NO) and arachidonic acid metabolites [14,21], increase hematopoiesis [35], exert radioprotective effects [12], are effective against burns [9,37], improve wound healing by inducing the macrophage release of wound growth factors [40] and lower serum lipids [4,23]. Among the several mechanisms proposed for the protective effects of -glucans, the major one is related to antioxidant capacity of the molecules [1,20], which has been further proven by Kogan et al [16] using electron paramagnetic response spectroscopy.…”

mentioning

confidence: 99%

Hepatoprotective Effects of Paramylon, a .BETA.-1,3-D-Glucan Isolated from Euglena gracilis Z, on Acute Liver Injury Induced by Carbon Tetrachloride in Rats

Sugiyama

Suzuki²,

Mitra³

et al. 2009

The Journal of Veterinary Medical Science

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ABSTRACT. Paramylon is a -(1-3)-D-glucan isolated from Euglena gracilis Z. This study was designed to evaluate the protective effects of paramylon on liver injury induced by carbon tetrachloride (CCl 4 ) in rats. Wistar stain male rats were orally administered paramylon (500, 1,000 and 2,000 mg/kg body weight) before treatment with a single intraperitoneal dose of 50% CCl 4 (2 ml/kg body weight). The rats were sacrificed 24 hr later, and blood samples were collected for assay of serum biochemical parameters. The livers were excised to evaluate the activity of antioxidant enzymes. Histopathological examination of the livers was also performed. The results showed that the treatment of paramylon prevented elevation of the serum levels of hepatic enzyme markers and inhibited fatty degeneration and hepatic necrosis induced by CCl 4 . Pre-administration of paramylon reduced the liver apoptotic index. The treatment of paramylon recovered reductions of activity of hepatic superoxide dismutase, catalase and glutathione peroxidase induced by CCl 4 . These results demonstrate that paramylon exhibits protective action on acute hepatic injury induced by CCl 4 via an antioxidative mechanism. To the best of our knowledge, this is the first report of a hepatoprotective effect based on the antioxidative action of paramylon.

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β-glucan protects against burn-induced oxidative organ damage in rats

Cited by 89 publications

References 58 publications

Melatonin Protection against Burn-Induced Hepatic Injury by Down-Regulation and Nuclear Factor Kappa B Activation

Melatonin Protection against Burn-Induced Hepatic Injury by Down-Regulation and Nuclear Factor Kappa B Activation

Effects of beta-glucan on hepatic damage caused by obstructive jaundice

Hepatoprotective Effects of Paramylon, a .BETA.-1,3-D-Glucan Isolated from Euglena gracilis Z, on Acute Liver Injury Induced by Carbon Tetrachloride in Rats

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