“…GM1 gangliosidosis is a rare, fatal, neurodegenerative genetic disease caused by mutations in the GLB1 gene, resulting in deficiency of β-galactosidase enzyme activity and accumulation of glycoconjugates with a terminal β-galactose, including gangliosides GM1 and GA1, oligosaccharides, glycopeptides, and keratan sulfate. 1 , 2 , 3 GM1 gangliosidosis is estimated to affect 1 in 100,000–200,0000 live births. 2 , 3 , 4 The major clinical signs are progressive motor and cognitive decline, visual defects, and premature death.…”