β-eudesmol but not atractylodin exerts an inhibitory effect on CFTR-mediated chloride transport in human intestinal epithelial cells

Tharabenjasin, Phuntila; Ferraris, Ronaldo P.; Choowongkomon, Kiattawee; Pongkorpsakol, Pawin; Worakajit, Nichakorn; Sawasvirojwong, Sutthipong; Na‐Bangchang, Kesara; Muanprasat, Chatchai

doi:10.1016/j.biopha.2021.112030

Cited by 1 publication

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“…The β‐eudesmol content was decreased 1.22‐fold in AC. β‐Eudesmol combined with atractylodin induces cell cycle arrest and apoptosis in a cholangiocarcinoma cell line and inhibits CFTR (cystic fibrosis transmembrane conductance regulator)‐mediated chloride transport in human intestinal epithelial cells 29,30 …”

Section: Discussionmentioning

confidence: 99%

“…β-Eudesmol combined with atractylodin induces cell cycle arrest and apoptosis in a cholangiocarcinoma cell line and inhibits CFTR (cystic fibrosis transmembrane conductance regulator)-mediated chloride transport in human intestinal epithelial cells. 29,30 The other differential volatile compounds such as β-bisabolene are studied for their anticancer properties in breast cancer. 31 Bornyl acetate has an anti-inflammatory effect in human chondrocytes and inhibits the proliferation of a variety of cancer cells.…”

Section: The Comparison Of Volatile Components From Cultivated and Wildmentioning

confidence: 99%

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HS‐SPME coupled with GC–MS for elucidating differences between the volatile components in wild and cultivated Atractylodes chinensis

Lei

Jiao

Yin

et al. 2023

Phytochemical Analysis

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Introduction: Atractylodes chinensis is a Chinese herb that is used in traditional medicine; it contains volatile components that have enormous potential for pharmaceutical, food, and cosmetic applications. The destruction of wild resources demands significant improvement in the quality of artificial cultivation of Atractylodes chinensis.However, little is known about the compositional differences in the volatile substances derived from the wild and cultivated varieties of Atractylodes chinensis.Objectives: We aimed to evaluate the specific components of Atractylodes chinensis and analyse the similarities and differences between the volatile components and metabolic pathways in the wild and cultivated varieties.Material and methods: Metabolomic analysis using gas chromatography-mass spectrometry (GC-MS) was employed following the extraction of volatile components from Atractylodes chinensis using headspace solid-phase microextraction (HS-SPME).Results: A total of 167 volatile metabolites were extracted, and 137 substances were matched with NIST and Wiley databases. Among them, 76 compounds exhibited significant differences between the two sources; these mainly included terpenes, aromatics, and esters. KEGG enrichment analysis indicated that the differential metabolites were primarily involved in the biosynthesis of secondary metabolites, terpene biosynthesis, and limonene and pinene degradation; all these pathways have geranyl diphosphate (GDP) as the common link. Conclusion:The total content of volatile substances extracted from wild Atractylodes chinensis was 2.5 times higher than that from the cultured variety; however, each source had different dominant metabolites. This study underscores the necessity for protecting wild Atractylodes chinensis resources, while enhancing the quality of cultivated Atractylodes chinensis.

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Section: Discussionmentioning

confidence: 99%

Section: The Comparison Of Volatile Components From Cultivated and Wildmentioning

confidence: 99%

HS‐SPME coupled with GC–MS for elucidating differences between the volatile components in wild and cultivated Atractylodes chinensis

Lei

Jiao

Yin

et al. 2023

Phytochemical Analysis

View full text Add to dashboard Cite

show abstract

β-eudesmol but not atractylodin exerts an inhibitory effect on CFTR-mediated chloride transport in human intestinal epithelial cells

Cited by 1 publication

References 45 publications

HS‐SPME coupled with GC–MS for elucidating differences between the volatile components in wild and cultivated Atractylodes chinensis

HS‐SPME coupled with GC–MS for elucidating differences between the volatile components in wild and cultivated Atractylodes chinensis

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