β‐Defensin 1 haplotype associated with postoperative endophthalmitis

Carter, James G.; West, Stephanie K.; Painter, Sally; Haynes, Richard; Churchill, Amanda J.

doi:10.1111/j.1755-3768.2009.01534.x

Cited by 10 publications

(7 citation statements)

References 22 publications

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“…The anatomical and functional prognosis is multifactorial (Carter et al. 2010) in this trauma context, with serious initial lesions such as RD ( n = 2) or choroidal haemorrhage ( n = 1).…”

Section: Discussionmentioning

confidence: 99%

A multicentre prospective study of post‐traumatic endophthalmitis

Cornut

Youssef

Bron

et al. 2012

Acta Ophthalmologica

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ABSTRACT.Purpose: Study the clinical and microbiological characteristics and the prognostic factors of post-traumatic endophthalmitis. Methods: Seventeen eyes were included between 2004 and 2010, with clinical and microbiological data collected prospectively. Conventional cultures and panbacterial PCR were performed on aqueous and vitreous samples. Results: Clinical signs of endophthalmitis were observed soon after trauma (1.5 ± 2.5 days). Laceration with an intraocular foreign body (IOFB) was noted in 53% of the patients. At admission, all patients had aqueous humour (71%) and ⁄ or vitreous (53%) samples. Fifteen patients (88%) underwent a pars plana vitrectomy. Bacteria were identified in 77% of the cases: Staphylococcus epidermidis (n = 5), Streptococcus (n = 4), Bacillus (n = 2), Pseudomonas stuzeri (n = 1), and Streptococcus salivarius and Gemella haemolysans (multibacterial infection, n = 1). Progression toward phthisis was observed in 35% of the cases; 41% of the patients recuperated visual acuity (VA) ‡20 ⁄ 40. A good final visual prognosis ( ‡20 ⁄ 40) was significantly associated with initial VA better than light perception (0% versus 70%, p = 0.01) and absence of pupillary fibrin membrane (80% versus 20%, p = 0.05). There was no correlation between visual prognosis and age, the type of laceration (corneal or scleral) or presence of an IOFB. We found a statistical trend toward an association between bacterial virulence and poor final VA. Conclusion: This series showed that better final VA outcomes were associated with initial VA better than light perception, S. epidermidis or culture-negative cases and absence of retinal detachment during the clinical course.

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“…The anatomical and functional prognosis is multifactorial (Carter et al. 2010) in this trauma context, with serious initial lesions such as RD ( n = 2) or choroidal haemorrhage ( n = 1).…”

Section: Discussionmentioning

confidence: 99%

A multicentre prospective study of post‐traumatic endophthalmitis

Cornut

Youssef

Bron

et al. 2012

Acta Ophthalmologica

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“…DEFB1 is expressed in multiple cell types of the immune system such as macrophages, monocytes, dendritic cells, and leukocytes. More importantly, epithelial cells in many organs such as pancreas, skin, kidney, respiratory system, and digestive tract express high levels of DEFB1 [ 32 , 33 ]. Initially, DEFB1 was thought to be constitutively expressed in the body, but subsequent evidence suggested that its expression is regulated under specific conditions.…”

Section: Discussionmentioning

confidence: 99%

Association between Genetic Polymorphisms in DEFB1 and Susceptibility to Digestive Diseases

Huang

Wang

et al. 2015

Med Sci Monit

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BackgroundAberrant expression of defensins is implicated in the pathogenesis of digestive diseases. However, the contribution of specific defensins and the influence of their genetic polymorphisms on the progression of digestive diseases remain controversial. In the present meta-analysis, we investigated the association between DEFB1 SNPs and the susceptibility to digestive diseases.Material/MethodsCase-control studies that reported the correlation between DEFB1 SNPs and the susceptibility to digestive diseases were identified through electronic databases searches, and high-quality studies that satisfied our inclusion criteria were selected for this meta-analysis. Statistical analyses were performed utilizing STATA software version 12.0.ResultsThe present meta-analysis revealed that patients with digestive diseases exhibited higher frequencies of the DEFB1 genetic variants rs11362G>A, rs1800972C>G, and rs1799946G>A compared to healthy controls under the allele model. Subgroup analysis based on country showed that the rs1800972C>G variant under allele model and rs1799946G>A are associated with the susceptibility to digestive diseases in Hungarian and Italian populations, respectively. Subgroup analysis based on disease type showed that: (1) rs11362G>A variant was strongly associated with severe acute pancreatitis (SAP) and chronic gastritis, (2) frequency of rs1800972C>G variant was higher in SAP subgroup, and (3) frequency of rs1799946G>A variant was positively associated with the susceptibility to Crohn’s disease (CD) under the allele model and with SAP.ConclusionsOur meta-analysis provides evidence that DEFB1 genetic polymorphisms rs11362G>A, rs1800972C>G and rs1799946G>A are important contributing factors to the development of digestive diseases.

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“…To the best of our knowledge, the information regarding comparative distribution of DEFB1 polymorphisms among various populations is limited and, among admixed, HIV/AIDS patient populations from the United States, is not available. The majority of studies have been conducted in European populations (Braida et al, 2004;Ricci et al, 2009;Carter et al, 2010;Schaefer et al, 2010). Limited information is available regarding the distribution of DEFB1 polymorphisms in other populations, such as Asian (Leung et al, 2006;Chen et al, 2007;Kim et al, 2009), African (Mozambican) (Baroncelli et al, 2008), Brazilian Segat et al, 2009), American, either mixed (Jurevic et al, 2003;Ozturk et al, 2010) or Caucasian-American and Af-Am and Mexican (Prado-Montes de Oca et al, 2006).…”

Section: Discussionmentioning

confidence: 99%

Variation in human β‐defensin genes: new insights from a multi‐population study

Mehlotra

Zimmerman

Weinberg

et al. 2012

Int J Immunogenetics

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Summary Human β-defensin 2 (hBD-2) and hBD-3, encoded by DEFB4 and DEFB103A, respectively, have shown anti-HIV activity, and both genes exhibit copy number variation (CNV). Although the role of hBD-1, encoded by DEFB1, in HIV-1 infection is less clear, single nucleotide polymorphisms (SNPs) in DEFB1 may influence viral loads and disease progression. We examined the distribution of DEFB1 SNPs and DEFB4/103A CNV, and the relationship between DEFB1 SNPs and DEFB4/103A CNV using samples from two HIV/AIDS cohorts from the United States (n = 150) and five diverse populations from the Coriell Cell Repositories (n = 46). We determined the frequencies of 10 SNPs in DEFB1 by using a post-PCR, oligonucleotide ligation detection reaction-fluorescent microsphere assay, and CNV in DEFB4/103A by real-time quantitative PCR. There were noticeable differences in the frequencies of DEFB1 SNP alleles and haplotypes among various racial/ethnic groups. The DEFB4/103A copy numbers varied from 2 to 8 (median, 4), and there was a significant difference between the copy numbers of self-identified whites and blacks in the US cohorts (Mann-Whitney U test p = 0.04). A significant difference was observed in the distribution of DEFB4/103A CNV among DEFB1 -52G/A and -390T/A genotypes (Kruskal-Wallis p = 0.017 and 0.026, respectively), while not in the distribution of DEFB4/103A CNV among -52G/A_-44C/G_-20G/A diplotypes. These observations provide additional insights for further investigating the complex interplay between β-defensin genetic polymorphisms and susceptibility to, or the progression or severity of, HIV infection/disease.

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β‐Defensin 1 haplotype associated with postoperative endophthalmitis

Cited by 10 publications

References 22 publications

A multicentre prospective study of post‐traumatic endophthalmitis

A multicentre prospective study of post‐traumatic endophthalmitis

Association between Genetic Polymorphisms in DEFB1 and Susceptibility to Digestive Diseases

Variation in human β‐defensin genes: new insights from a multi‐population study

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