β-defensin 1 Gene Polymorphisms are Associated with Kidney Disease in Northwestern Mexicans with Type 2 Diabetes

Ochoa‐Ramírez, Luis Antonio; Millán, J R; Vázquez, Luis Fernando Mendoza; Díaz‐Camacho, Sylvia Páz; Quiñonez, Samantha Isabel Verdugo; Rojas-Herrera, Dulce Carolina; Castro, Martín López; de, Ernesto Prado Montes; Velarde‐Félix, Jesús Salvador

doi:10.1080/08820139.2021.1948564

Cited by 2 publications

(1 citation statement)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For example, hBD1-3 is down-regulated, and HNP1-3 is upregulated, in the serum of individuals with type 1 diabetes (T1D). 360 – 363 According to a prospective study examining cardiovascular risk factors, individuals belonging to the highest quartile for plasma HNP1-3 show a significant correlation with being leaner, more insulin sensitive and possessing lower levels of total and LDL-cholesterol. 364 On the other hand, those belonging to the lowest quartile for circulating HNP1-3 lack these benefits.…”

Section: Clinical Relevance and Therapeutic Potential Of Defensinsmentioning

confidence: 99%

Mechanisms and regulation of defensins in host defense

Zong

Jin

et al. 2023

Sig Transduct Target Ther

View full text Add to dashboard Cite

As a family of cationic host defense peptides, defensins are mainly synthesized by Paneth cells, neutrophils, and epithelial cells, contributing to host defense. Their biological functions in innate immunity, as well as their structure and activity relationships, along with their mechanisms of action and therapeutic potential, have been of great interest in recent years. To highlight the key research into the role of defensins in human and animal health, we first describe their research history, structural features, evolution, and antimicrobial mechanisms. Next, we cover the role of defensins in immune homeostasis, chemotaxis, mucosal barrier function, gut microbiota regulation, intestinal development and regulation of cell death. Further, we discuss their clinical relevance and therapeutic potential in various diseases, including infectious disease, inflammatory bowel disease, diabetes and obesity, chronic inflammatory lung disease, periodontitis and cancer. Finally, we summarize the current knowledge regarding the nutrient-dependent regulation of defensins, including fatty acids, amino acids, microelements, plant extracts, and probiotics, while considering the clinical application of such regulation. Together, the review summarizes the various biological functions, mechanism of actions and potential clinical significance of defensins, along with the challenges in developing defensins-based therapy, thus providing crucial insights into their biology and potential clinical utility.

show abstract

Section: Clinical Relevance and Therapeutic Potential Of Defensinsmentioning

confidence: 99%