β-D-Glucosiduronic Acid Conjugation by the Mucosa of Various Organs

Hepatic Conversion of Bilirubin Monoglucuronide to Diglucuronide in Uridine Diphosphate-Glucuronyl Transferase-Deficient Man and Rat by Bilirubin Glucuronoside Glucuronosyltransferase

“…Recent studies (2) ofthe bilirubin conjugating system in rat and human liver reveal that two distinct enzymes are required for formation of bilirubin diglucuronide. UDPglucuronate glucuronyltransferase the microsomal enzyme required for conversion of bilirubin to bilirubin monoglucuronide, is present in the renal cortex (16), small intestinal mucosa (17), and liver. Bilirubin monoglucuronide transglucuronidation activity is present in rat liver and renal cortex (18), but not in erythrocyte Results are expressed as mean+SE.…”