β-Cyclodextrin covalent organic framework modified-cellulose acetate membranes for enantioseparation of chiral drugs

Recent Advances in Separation and Analysis of Chiral Compounds

“…146 A 20 wt % CD-MOF loading was tested to achieve a stable and high enantioselectivity for the separation of one enantiomer of 1-phenylethanol from the racemic mixture. Luo et al 147 used β-CD COF as the chiral selector to fabricate β-CD COF MMM with cellulose acetate. The solute flux using the β-CD COF MMM was about 40 nmol cm −2 h −1 , and the e.e.…”

“…148 Compared to MMMs that might suffer from the block of chiral pores and the formation of achiral pores, TFNs can achieve a chiral recognition thin film with less chiral pore defects and a better selectivity. Luo et al 147 also prepared the β-CD COF TFN and compared it with β-CD COF MMM. β-CD COF TFN achieved an optimal enantioselectivity of D,L-tryptophan (e.e.…”

Macrocycle‐Based Covalent Organic Frameworks

“…The postfunctionalized COFs with dual-chiral groups showed excellent separation efficiency toward acidic chiral drugs. Luo et al [89] employed interfacial polymerization strategy to synthesize β-CD-COFs mixed matrix membrane by using the cellulose acetate, where the β-CD-COFs were constructed by the heptakis (6-amino-6-deoxy)-β-CD and terephthalaldehyde. Such a β-CD-COFs membrane showed high permeability and enantioselectivity to four chiral drugs, D, L -tryptophan, (RS)-mandelic acid, d,l-phenylalanine, and (RS)-propranolol.…”

Enantioseparation Membranes: Research Status, Challenges, and Trends

“…Ji's research group [74] reported novel COF membranes for chiral drug separation. Using β-cyclodextrin covalent organic framework (β-CD COF) as a chiral selective agent, two types of β-CD COF membranes were prepared by physical and chemical modifications including β-CD COF MMM and β-CD COF thin film nanocomposite membrane (β-CD COF TFN).…”