β-Cyclodextrin conjugated magnetic, fluorescent silica core–shell nanoparticles for biomedical applications

Badruddoza, Abu Zayed Md; Rahman, Md. Taifur; Ghosh, Sudipa; Hossain, Md. Zakir; Jizhong, Shi; Hidajat, K.; Uddin, M.S.

doi:10.1016/j.carbpol.2013.02.046

Cited by 87 publications

(48 citation statements)

References 50 publications

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“…For example, MNPs coated with chitosan and linoleic acid can be used for gene delivery to hepatocytes . And, Badruddoza et al encapsulated Fe 3 O 4 in a shell of SiO 2 to improve biocompatibility of their nanocomposite . Their magnetic nanocomposite was demonstrated to be highly dispersible in an aqueous medium and benign toward healthy cells.…”

Section: Mnpsmentioning

confidence: 99%

Current investigations into magnetic nanoparticles for biomedical applications

Jiang

Aifantis

et al. 2016

J Biomedical Materials Res

275

166

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It is generally recognized that nanoparticles possess unique physicochemical properties that are largely different from those of conventional materials, specifically the electromagnetic properties of magnetic nanoparticles (MNPs). These properties have attracted many researchers to launch investigations into their potential biomedical applications, which have been reviewed in this article. First, common types of MNPs were briefly introduced. Then, the biomedical applications of MNPs were reviewed in seven parts: magnetic resonance imaging (MRI), cancer therapy, the delivery of drugs and genes, bone and dental repair, tissue engineering, biosensors, and in other aspects, which indicated that MNPs possess great potentials for many kinds of biomedical applications due to their unique properties. Although lots of achievements have been obtained, there is still a lot of work to do. New synthesis techniques and methods are still needed to develop the MNPs with satisfactory biocompatibility. More effective methods need to be exploited to prepare MNPs-based composites with fine microstructures and high biomedical performances. Other promising research points include the development of more appropriate techniques of experiments both in vitro and in vivo to detect and analyze the biocompatibility and cytotoxicity of MNPs and understand the possible influencing mechanism of the two properties. More comprehensive investigations into the diagnostic and therapeutic applications of composites containing MNPs with "core-shell" structure and deeper understanding and further study into the properties of MNPs to reveal their new biomedical applications, are also described in the conclusion and perspectives part.

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Section: Mnpsmentioning

confidence: 99%

Current investigations into magnetic nanoparticles for biomedical applications

Jiang

Aifantis

et al. 2016

J Biomedical Materials Res

275

166

View full text Add to dashboard Cite

show abstract

“…The polymeric shell provides biocompatibility, prevents agglomeration, and acts as a drug reservoir. Several polymers such as starch, dextran [54,55], PEG [51,56], fatty acids, polyvinyl alcohol [57], polyacrylic acid, poly lactides, gelatin, silica [58,59,56], oleic acid [60,61], PLGA or poly(D,L-lacticco-glycolic acid) [62], polyethylene imine (PEI) [63], poly methyl methacrylate (PMMA), and polyacrylic acid (PAA) [59,64], albumin [50,41], and chitosan [64] have been used as coating materials for different purposes. Conjugation of outer shell with different targeting molecules can promote sitespecific function of magnetic NPs.…”

Section: Magnetic Nanoparticlesmentioning

confidence: 99%

Folate-conjugated nanoparticles as a potent therapeutic approach in targeted cancer therapy

et al. 2015

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The selective and efficient drug delivery to tumor cells can remarkably improve different cancer therapeutic approaches. There are several nanoparticles (NPs) which can act as a potent drug carrier for cancer therapy. However, the specific drug delivery to cancer cells is an important issue which should be considered before designing new NPs for in vivo application. It has been shown that cancer cells over-express folate receptor (FR) in order to improve their growth. As normal cells express a significantly lower levels of FR compared to tumor cells, it seems that folate molecules can be used as potent targeting moieties in different nanocarrier-based therapeutic approaches. Moreover, there is evidence which implies folate-conjugated NPs can selectively deliver anti-tumor drugs into cancer cells both in vitro and in vivo. In this review, we will discuss about the efficiency of different folate-conjugated NPs in cancer therapy.

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“…It has excellent potential for physiological applications such as targeted drug and gene delivery [6,25,26]，cell and protein separation [8,27], magnetic resonance (MR) imaging [5,28] and cancer therapy (hyperthermia) [7,29]. The MNPs could be flexibly designed and synthesized as multifunctional nanoparticles via modifying ligands on the surface according to different application purposes [30,31]. Meanwhile, there is report that MNPs could be used in CSCs identification via the specific targeting ligands on the surface [32].…”

Section: Introductionmentioning

confidence: 97%