β‐cyclodextrin‐conjugated hyaluronan hydrogel as a potential drug sustained delivery carrier for wound healing

Abstract

In order to develop a potential drug sustained delivery carrier suitable for wound healing, a series of b-cyclodextrin conjugated hyaluronan hydrogels (b-CD-HA) with adjustable crosslink densities were synthesized and characterized, meanwhile the delivery kinetics and mechanism of diclofenac as a model anti-inflammatory drug from these hydrogels were investigated. By controlling the feeding molar ratio of b-CD/HA, a b-CD substitution degree of 4.65% was obtained by 1 H-NMR analysis. The incorporation of b-CD modification had little effect on the internal porous structure, water swelling ratio, and rheological property of HA hydrogel, which however were influenced by the crosslink density. Although the crosslink density had an influence on the drug loading and release profile by altering the water swelling property, the interaction between b-CD and drug was the primary factor for the high loading capacity and long-term sustained delivery of diclofenac. The semiempirical equation fit showed that the release of diclofenac from HA-based hydrogels followed a pseudo-Fickian diffusion mechanism. By the aid of b-CD and controlled crosslink density, a b-CD-HA hydrogel with a diclofenac sustained delivery period of over 28 days and desirable physicochemical properties was achieved, which will be a promising drug sustained delivery carrier for wound healing. V C 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016, 133, 43072.

Biodegradable β‐Cyclodextrin Conjugated Gelatin Methacryloyl Microneedle for Delivery of Water‐Insoluble Drug

“…Characteristic peaks at 4.8 and 5.7 ppm (region IV) were representative of protons in the glucose ring from CM‐ β ‐CD. [ 23 ] Similarly, in the FTIR spectra (Figure 2B) the conjugated GelMA‐ β ‐CD displayed strong absorption at 1150–1070 cm −1 in enclosed region IV corresponding to the ether group of the CM‐ β ‐CD. In addition, strong peaks at 1500–1700 cm −1 (shown in enclosed region III) came from amide bonds presented in the backbone of the GelMA polymer.…”

“…GelMA‐ β ‐CD was synthesized based on the previously reported method with minor modifications. [ 23,49 ] Briefly, the synthesized GelMA (300 mg) described above was dissolved in 3 mL DPBS (pH = 7.4) and kept in an 80 °C oven to fully dissolve. Different amounts of CM‐ β ‐CD (200, 400, and 600 mg) were added into 3 mL MES buffer (2‐( N ‐morpholino) ethanesulfonic acid, pH = 6) followed by the addition of EDC and NHS to activate the carboxyl group for 30 min.…”

Construction of a water-soluble and photostable rubropunctatin/β-cyclodextrin drug carrier

“…Results showed that the high loading capacity and sustained drug delivery was caused by the interaction between b-cyclodextrin and the drug. 25 Modied cyclodextrin has been prepared as an injectable drug carrier, one successful example being Sporanox. 26 Related studies have shown that the formation of inclusion complexes can be characterized by UV-vis, SEM, Fourier transform-infrared spectroscopy, molecular docking, NMR, X-ray diffraction, and other techniques.…”

Nanomaterials in wound healing: From material sciences to wound healing applications

“…Sustained delivery of a model drug of over 28 days. [81] Lipid nanoparticles Morphine-loaded solid lipid nanoparticles…”