β-cyclodextrin chitosan-based hydrogels with tunable pH-responsive properties for controlled release of acyclovir: design, characterization, safety, and pharmacokinetic evaluation

Malik, Nadia Shamshad; Ahmad, Mahmood; Alqahtani, Mohammed S.; Mahmood, Arshad; Barkat, Kashif; Khan, Muhammad Tariq; Tulain, Ume Ruqia; Rashid, Ayesha

doi:10.1080/10717544.2021.1921074

Cited by 31 publications

(7 citation statements)

References 76 publications

(68 reference statements)

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“…Conversely, in BA4-BA6 hydrogels, as the maximum q arose from 29.38 to 55.55, the DLE% rose from 72.58% to 90.33%. The reason for the increase in DLE% is again clear that as more drug solution enters the hydrogel network with increase swelling, more drug is entrapped in hydrogels [ 26 ].…”

Section: Resultsmentioning

confidence: 99%

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Novel Black Seed Polysaccharide Extract-g-Poly (Acrylate) pH-Responsive Hydrogel Nanocomposites for Safe Oral Insulin Delivery: Development, In Vitro, In Vivo and Toxicological Evaluation

et al. 2022

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Oral delivery of insulin has always been a challenging task due to harsh gut environment involving variable pH and peptidase actions. Currently, no Food and Drug Administration (FDA) approved oral insulin formulation is commercially available, only intravenous (IV) or subcutaneous (SC) routes. Therefore, it is really cumbersome for diabetic patients to go through invasive approaches for insulin delivery on daily basis. In the present study, a novel pH-responsive hydrogel nanocomposite (NC) system was developed and optimized for safe oral delivery of insulin. Black seed polysaccharide extract-based hydrogel (BA hydrogel) was formulated by free radical polymerization and loaded with insulin. Blank BA hydrogel was also incorporated with insulin-loaded montmorillonite nanoclay (Ins-Mmt) to form an Ins-Mmt-BA hydrogel NC and compared with the insulin-loaded hydrogel. Swelling, sol-gel analysis and in vitro release studies proved that Ins-Mmt-BA6 hydrogel NC has the best formulation, with 96.17% maximum insulin released in 24 h. Kinetic modeling applied on insulin release data showed the Korsemeyer-Peppas model (R2 = 0.9637) as the best fit model with a super case II transport mechanism for insulin transport (n > 0.89). Energy Dispersive X-ray (EDX) Spectroscopy, Fourier Transformed Infrared (FTIR) spectroscopy and Powdered X-ray diffraction (PXRD) analysis results also confirmed successful development of a hydrogel NC with no significant denaturation of insulin. Toxicity results confirmed the safety profile and biocompatibility of the developed NC. In vivo studies showed a maximum decrease in blood glucose levels of 52.61% and percentage relative bioavailability (% RBA) of 26.3% for an Ins-Mmt-BA hydrogel NC as compared to BA hydrogels and insulin administered through the SC route.

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Section: Resultsmentioning

confidence: 99%

“…Here, actual drug is the total amount of drug calculated by the UV-visible spectrometer in the dosage unit. Meanwhile, added drug is the amount of total drug that was tried to be loaded in the dosage unit by adding in swelling medium [ 26 ].…”

Section: Methodsmentioning

confidence: 99%

Novel Black Seed Polysaccharide Extract-g-Poly (Acrylate) pH-Responsive Hydrogel Nanocomposites for Safe Oral Insulin Delivery: Development, In Vitro, In Vivo and Toxicological Evaluation

et al. 2022

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“…Malik et al [ 237 ] evaluated the preparation of a pH-responsive hydrogel as an oral-controlled drug delivery system for ACV. Different proportions of β-CD, (CS), methacrylic acid, and N′N′-methylenebis-acrylamide were used to fabricate hydrogels via the free radical polymerization technique.…”

Section: Cs-based Dosage Forms and Drug Delivery Systems For Antiviralsmentioning

confidence: 99%

Advances in Antiviral Delivery Systems and Chitosan-Based Polymeric and Nanoparticulate Antivirals and Antiviral Carriers

Dominika

Mikušová

Mikuš

2023

Viruses

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Current antiviral therapy research is focused on developing dosage forms that enable highly effective drug delivery, providing a selective effect in the organism, lower risk of adverse effects, a lower dose of active pharmaceutical ingredients, and minimal toxicity. In this article, antiviral drugs and the mechanisms of their action are summarized at the beginning as a prerequisite background to develop relevant drug delivery/carrier systems for them, classified and briefly discussed subsequently. Many of the recent studies aim at different types of synthetic, semisynthetic, and natural polymers serving as a favorable matrix for the antiviral drug carrier. Besides a wider view of different antiviral delivery systems, this review focuses on advances in antiviral drug delivery systems based on chitosan (CS) and derivatized CS carriers. CS and its derivatives are evaluated concerning methods of their preparation, their basic characteristics and properties, approaches to the incorporation of an antiviral drug in the CS polymer as well as CS nanoparticulate systems, and their recent biomedical applications in the context of actual antiviral therapy. The degree of development (i.e., research study, in vitro/ex vivo/in vivo preclinical testing), as well as benefits and limitations of CS polymer and CS nanoparticulate drug delivery systems, are reported for particular viral diseases and corresponding antivirotics.

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“…The degradation process is also dependent on the molecular weight of chitosan derivatives during mucus clearance, suggesting that the physical motion between mucus and chitosan might play an extra role on degradation. There are many other chitosan derivatives, including trimethyl chitosan, , carboxymethyl chitosan, − thiolated chitosan, − acrylated chitosan, − half-acetylated chitosan, , glycol chitosan, − chitosan conjugates, − chitosan–catechol, , methylpyrrolidinone chitosan, , cyclodextrin–chitosan − and oleoyl-quaternized chitosan, that enhance the mucoadhesive properties and improve the particle transport through the McLs. Airway and intestinal mucosal organoids along with oral mucosal organoids have great potential for high-efficient drug delivery system design.…”

Section: Particle Transport Through Mclsmentioning

confidence: 99%

From Static to Dynamic: A Review on the Role of Mucus Heterogeneity in Particle and Microbial Transport

Pednekar

Liguori

Marques

et al. 2022

ACS Biomater. Sci. Eng.

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Mucus layers (McLs) are on the front line of the human defense system that protect us from foreign abiotic/biotic particles (e.g., airborne virus SARS-CoV-2) and lubricates our organs. Recently, the impact of McLs on human health (e.g., nutrient absorption and drug delivery) and diseases (e.g., infections and cancers) has been studied extensively, yet their mechanisms are still not fully understood due to their high variety among organs and individuals. We characterize these variances as the heterogeneity of McLs, which lies in the thickness, composition, and physiology, making the systematic research on the roles of McLs in human health and diseases very challenging. To advance mucosal organoids and develop effective drug delivery systems, a comprehensive understanding of McLs’ heterogeneity and how it impacts mucus physiology is urgently needed. When the role of airway mucus in the penetration and transmission of coronavirus (CoV) is considered, this understanding may also enable a better explanation and prediction of the CoV’s behavior. Hence, in this Review, we summarize the variances of McLs among organs, health conditions, and experimental settings as well as recent advances in experimental measurements, data analysis, and model development for simulations.

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β-cyclodextrin chitosan-based hydrogels with tunable pH-responsive properties for controlled release of acyclovir: design, characterization, safety, and pharmacokinetic evaluation

Abstract: Rashid (2021) βcyclodextrin chitosan-based hydrogels with tunable pH-responsive properties for controlled release of acyclovir: design, characterization, safety, and pharmacokinetic evaluation,

Cited by 31 publications

References 76 publications

Novel Black Seed Polysaccharide Extract-g-Poly (Acrylate) pH-Responsive Hydrogel Nanocomposites for Safe Oral Insulin Delivery: Development, In Vitro, In Vivo and Toxicological Evaluation

Novel Black Seed Polysaccharide Extract-g-Poly (Acrylate) pH-Responsive Hydrogel Nanocomposites for Safe Oral Insulin Delivery: Development, In Vitro, In Vivo and Toxicological Evaluation

Advances in Antiviral Delivery Systems and Chitosan-Based Polymeric and Nanoparticulate Antivirals and Antiviral Carriers

From Static to Dynamic: A Review on the Role of Mucus Heterogeneity in Particle and Microbial Transport

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