β-Cyclodextrin-Centered Star-Shaped Amphiphilic Polymers for Doxorubicin Delivery

Qiu, Li; Wang, Rong Juan; Cheng, Zheng; Jin, Yi; Jin, Le

doi:10.2217/nnm.09.108

Cited by 82 publications

(64 citation statements)

References 37 publications

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“…The CAC values were dependent on the block length of the PCL arm and decreased from 0.12 to 0.04 mM when PCL molecular weight increased from 3000 to 19,000 Da. Micelles with small CAC values are expected to be more stable against dilution after IV injections [36].…”

Section: Preparation and Characterization Of Nimodipine Miktoarm Micementioning

confidence: 99%

Tailoring the efficacy of nimodipine drug delivery using nanocarriers based on A2B miktoarm star polymers

Soliman¹,

Sharma²,

Choi³

et al. 2010

Biomaterials

117

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a b s t r a c tWe report a nanocarrier based on A 2 B type miktoarm polymers (A ¼ polyethylene glycol (PEG); B ¼ polycaprolactone (PCL)) for nimodipine (NIM), a hydrophobic drug with very poor aqueous solubility that is commonly prescribed for the prevention and treatment of delayed ischemic neurological disorders. The A 2 B star polymers were constructed on a core with orthogonal functionalities that facilitated the performance of "click" chemistry followed by ring-opening polymerization. These star polymers assemble into spherical micelles into which NIM can be easily loaded by the co-solvent evaporation method. The micelles obtained from the star polymer PEG775 2 ePCL5800 showed NIM encapsulation efficiency of up to 78 wt% at a feed weight ratio of 5.0%. The loading efficiency of the micelles was dependent on the length of the PCL arm in the A 2 B miktoarm polymers. Aqueous solubility of NIM was increased by w200 fold via micellar encapsulation. The in vitro release of NIM from the micelles was found to occur at a much slower rate than from its solution. Lipopolysaccharide induced nitric oxide production in N9 microglia cells was reduced in the presence of micelle-encapsulated NIM, as well as in the presence of micelles alone. The treatment of microglia with micelle-encapsulated NIM reduced the release of TNF-a, a pro-inflammatory cytokine. These results suggest that NIM-loaded miktoarm micelles could be useful in the treatment of neuroinflammation.

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Section: Preparation and Characterization Of Nimodipine Miktoarm Micementioning

confidence: 99%

Tailoring the efficacy of nimodipine drug delivery using nanocarriers based on A2B miktoarm star polymers

Soliman¹,

Sharma²,

Choi³

et al. 2010

Biomaterials

117

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“…The enhanced drug loading of PELA54-CD was attributed to the cooperation of the β-CD inclusion effect and the hydrophobic interactions of PLA with DOX. 23,24 The particle sizes of the resultant DOX-loaded micelles were distributed between 130 and 170 nm determined by DLS (Table 1) which was small enough to be transported from blood circulation to the tumor site via enhanced permeability and retention effect and further taken up by tumor cells after intravenous injection. Due to the inclusion action between β-CD and DOX, the particle size did not change much for DOX-loaded PELA54-CD or PEG5000-CD micelles in comparison to the corresponding blank micelles.…”

Section: Results and Discussion Synthesis And Characterization Of Polmentioning

confidence: 99%

“…23,24 First, PELA54 was polymerized by ring opening. 25,26 In brief, a predetermined amount of mPEG5000 and LA at 5:4 weight ratio was added to a dried tube with Sn(Oct) 2 /toluene (0.5 wt%) as a catalyst, and then toluene was vacuum evacuated and the tube was sealed.…”

mentioning

confidence: 99%

Synergistic effects of A-B-C-type amphiphilic copolymer on reversal of drug resistance in MCF-7/ADR breast carcinoma

Zhang¹,

Lü²,

Qiu³

2016

IJN

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P-glycoprotein (P-gp) overexpression has become the most common cause of occurrence of multidrug resistance in clinical settings. We aimed to construct a micellar polymer carrier to sensitize drug-resistant tumors to doxorubicin (DOX). This A-B-C-type amphiphilic copolymer was prepared by the sequential linkage of β-cyclodextrin, hydrophobic poly( d , l -lactide), and hydrophilic poly(ethylene glycol). Upon incubation of the DOX-loaded micelles with DOX-resistant human breast carcinoma MCF-7/ADR cells, significantly enhanced cytotoxicity and apoptosis were achieved. A series of studies on the action mechanism showed that the polymer components such as β-cyclodextrin, hydrophobic poly( d , l -lactide) segment, and poly(ethylene glycol) coordinatively contributed to the improved intracellular ATP depletion and ATPase activity, increased intracellular uptake of P-gp substrates via competitive binding to P-gp, and decreased P-gp expression in MCF-7/ADR cells. More interestingly, a similar phenomenon was observed in the zebrafish xenograft model, resulting in ~64% inhibition of MCF-7/ADR tumor growth. These results implied that the polymeric micelles displayed great potentials as P-gp modulators to reverse DOX resistance in MCF-7/ADR breast carcinoma.

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“…Qiu and coworkers developed advanced cyclodextrin-based formulation of DOXO (sPEL/CD) for which they reacted methoxy polyethylene glycol and poly lactic acid to obtain linear mPEG-PLA which entrenched like the arms of core β-cyclodextrin [ 87 ]. This delivery system was found to exhibit higher drug loading and entrapment effi ciency of 18 % and 84 %, respectively, attributable to the presence of poly lactic acid which increased the hydrophobic interaction between the polymer and DOXO along with allowing adequate lodging of DOXO by enlarging β-cyclodextrin inter spaces.…”

Section: Cyclodextrin Nanoparticlesmentioning

confidence: 99%

Nanotechnology to Combat Multidrug Resistance in Cancer

Akhter

Amin

Ahmad

et al. 2014

Resistance to Targeted Anti-Cancer Therapeutics

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Multidrug resistance (MDR) in cancer is a prime obstacle toward successful cancer chemotherapy which is the combination of the complicated mechanisms involving abnormal vasculature, localized area of hypoxia, upregulated ABC transporters, aerobic glycolysis, elevated apoptotic threshold, and increased interstitial fl uid pressure. Nanomedicines in targeted cancer chemotherapy hold great promise as an effective approach to prevail over MDR. Extensive research has been conducted to get success in development of Nanomedicines against MDR that introduced many of them as personalized medicine and in different clinical stages. Nanomedicines can be preferentially accumulated in tumor areas by EPR and by active targeting of upregulated processes such as ABC transporters of cancer cells. In this review, we aimed to discuss different nanomedicines that showed promises against MDR in cancer and improved the chemotherapeutic effi cacy in the last decade. Moreover, different cellular and physiological factors that underlie MDR in cancer will also be discussed.

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β-Cyclodextrin-Centered Star-Shaped Amphiphilic Polymers for Doxorubicin Delivery

Cited by 82 publications

References 37 publications

Tailoring the efficacy of nimodipine drug delivery using nanocarriers based on A2B miktoarm star polymers

Tailoring the efficacy of nimodipine drug delivery using nanocarriers based on A2B miktoarm star polymers

Synergistic effects of A-B-C-type amphiphilic copolymer on reversal of drug resistance in MCF-7/ADR breast carcinoma

Nanotechnology to Combat Multidrug Resistance in Cancer

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