β -Cyclodextrin as a supramolecular catalyst for the synthesis of 2 H -indazolo[2,1- b ]phthalazine-trione derivatives in water and their antimicrobial activities

Chate, Asha V.; Bhadke, Priyanka K.; Khande, Manisha A.; Sangshetti, Jaiprakash N.; Gill, Charansingh H.

doi:10.1016/j.cclet.2017.03.007

Cited by 38 publications

(12 citation statements)

References 41 publications

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“…1). The catalytic role of this catalyst has been compared with various reported catalysts in mentioned way and remarkable results has been concluded [54,55]. As illustrated in Scheme 1, this newly synthesized N-propyl sulfamic acid functionalized polymeric catalyst preparation steps include the synthesis of calix [4]resorcinarene (1) as the result of the reaction between resorcinol and acetaldehyde [9], polymerization with formaldehyde to develop product (2) [19], modification with APTES resulting in structure (3) [13] and finally product (4) formation through the addition of chlorosulfonic acid (Scheme 1).…”

Section: Resultsmentioning

confidence: 95%

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Design and synthesis of a new porous organic polymer equipped with N‐propyl sulfamic acid functionalities: As an efficient heterogeneous catalyst for the synthesis of 1,8‐dioxo‐octahydroxanthene derivatives

Mouradzadegun

Mostafavi

2017

Polymer Engineering & Sci

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The manuscript reports the synthesis of a polymeric calix[4]resorcinarene catalyst incorporated with N‐propyl sulfamic acid and the catalytic synthesis of 1,8‐dioxo‐octahydroxanthenes by this polymeric catalyst. Highly cross‐linked porous organic polymers as a class of amorphous and nano‐scale porous polymeric networks have been playing a key role in the development of organic synthesis and catalytic systems. The catalyst synthetic steps include (1) the synthesis of calix[4]resorcinarene, (2) polymerization with formaldehyde, (3) modification with 3‐(triethoxysilyl)propylamine (APTES), and finally (4) modification in the presence of chlorosulfonic acid to produce an efficient heterogeneous acidic catalyst for being applied in the condensation reaction of dimedone with divergent aryl aldehydes for synthesizing a series of 1,8‐dioxo‐octahydroxanthenes. This newly synthesized catalyst was characterized by some spectroscopic methods such as Fourier‐Transform Infrared spectroscopy (FT‐IR), elemental analysis (CHNS), field emission scanning electron microscopy (FE‐SEM), transmission electron microscopy (TEM), gas adsorption/desorption Brunauer‐Emmett‐Teller (BET) methodology, and thermogravimetric analysis (TGA) and its recyclability was successfully proved. Solvent‐free conditions, easy reaction handling and work up, mild acidic conditions, green and affordable methodology, gaining high yields of products in short reaction times, and also the catalyst reusability, are the most important advantages of the present method. POLYM. ENG. SCI., 58:1362–1370, 2018. © 2017 Society of Plastics Engineers

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Section: Resultsmentioning

confidence: 95%

“…). The catalytic role of this catalyst has been compared with various reported catalysts in mentioned way and remarkable results has been concluded .…”

Section: Resultsmentioning

confidence: 95%

Design and synthesis of a new porous organic polymer equipped with N‐propyl sulfamic acid functionalities: As an efficient heterogeneous catalyst for the synthesis of 1,8‐dioxo‐octahydroxanthene derivatives

Mouradzadegun

Mostafavi

2017

Polymer Engineering & Sci

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“…These potential properties have prompted many efforts toward the synthesis of spirooxindole‐fused heterocycles, and numerous impressive successes have been obtained for the synthesis of the diversely structured spirocyclic oxindoles . Therefore, owing to our interest in the synthesis of biologically active scaffolds , herein, we have designed and synthesized novel spiro [pyrimido[5,4‐b]quinoline‐10,5′‐pyrrolo[2,3‐d]pyrimidine] derivatives by aiming at the identification of new chemical entities (NCEs) as potent cytotoxic agents. We have attached the structural features of spirooxindoles to the head part and various fundamental building blocks like acridine to the tail part (Fig.…”

Section: Introductionmentioning

confidence: 99%

Design, Synthesis and SAR Study of Novel Spiro [Pyrimido[5,4‐b]Quinoline‐10,5′‐Pyrrolo[2,3‐d]Pyrimidine] Derivatives as Promising Anticancer Agents

Chate

Kamdi

Bhagat

et al. 2018

Journal of Heterocyclic Chem

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Novel spiro [pyrimido[5,4‐b]quinoline‐10,5′‐pyrrolo[2,3‐d]pyrimidine] derivatives were designed and synthesized, and their chemical structures were confirmed by IR, NMR, elemental analysis, and mass spectral analysis. The anticancer activities of the newly synthesized compounds were evaluated in vitro against four human cancer cell lines including A431, PC‐3, MCF‐7, and MCF‐10A by MTT assay. The screening results showed that three compounds (4m, 4q, and 4s) exhibited potent cytotoxic activities with IC50 values between 7.82 and 9.88 μM against human breast cancer cell line (MCF‐7). Further in vitro studies revealed that inhibition of Sunitinib could be the possible mechanism of action of these molecules.

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“…Supramolecular catalysis has drawn tremendous interest in the past few years [15–23]. In this context, calixarenes are ideal supramolecular macrocyclic scaffolds for the design of molecular receptors and organocatalysts due to their unique and tunable molecular architecture together with the ease of functionalization on the lower and upper rims [24–28].…”

Section: Introductionmentioning

confidence: 99%

Asymmetric Michael addition reactions catalyzed by calix[4]thiourea cyclohexanediamine derivatives

Tong

Chen

et al. 2018

Beilstein J. Org. Chem.

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A number of upper rim-functionalized calix[4]thiourea cyclohexanediamine derivatives have been designed, synthesized and used as catalysts for enantioselective Michael addition reactions between nitroolefins and acetylacetone. The optimal catalyst 2 with a mono-thiourea group exhibited good performance in the presence of water/toluene (v/v = 1:2). Under the optimal reaction conditions, high yields of up to 99% and moderate to good enantioselectivities up to 94% ee were achieved. Detailed experiments clearly showed that the upper rim-functionalized hydrophobic calixarene scaffold played an important role in cooperation with the catalytic center to the good reactivities and enantioselectivities.

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β -Cyclodextrin as a supramolecular catalyst for the synthesis of 2 H -indazolo[2,1- b ]phthalazine-trione derivatives in water and their antimicrobial activities

Cited by 38 publications

References 41 publications

Design and synthesis of a new porous organic polymer equipped with N‐propyl sulfamic acid functionalities: As an efficient heterogeneous catalyst for the synthesis of 1,8‐dioxo‐octahydroxanthene derivatives

Design and synthesis of a new porous organic polymer equipped with N‐propyl sulfamic acid functionalities: As an efficient heterogeneous catalyst for the synthesis of 1,8‐dioxo‐octahydroxanthene derivatives

Design, Synthesis and SAR Study of Novel Spiro [Pyrimido[5,4‐b]Quinoline‐10,5′‐Pyrrolo[2,3‐d]Pyrimidine] Derivatives as Promising Anticancer Agents

Asymmetric Michael addition reactions catalyzed by calix[4]thiourea cyclohexanediamine derivatives

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