β-Cell function is associated with osteosarcopenia in middle-aged and older nonobese patients with type 2 diabetes: A cross-sectional study

Abstract

Type 2 diabetes mellitus (T2DM) is a strong risk tfactor for osteosarcopenia. The relationship between musculoskeletal index and β-cell function remains controversial. We aimed to describe the clinical characteristics of osteosarcopenia and to explore the association between osteosarcopenia and β-cell function, as well as insulin resistance in patients with T2DM. A total of 150 middle-aged and older nonobese patients with T2DM were recruited. Bone mineral density (BMD) and body composition were measured by the dual-energy X-ray absorptiometry scanner. The homeostasis model assessment of insulin resistance and Matsuda index were used to evaluate insulin resistance status. β-Cell function was estimated by the area under the curve insulin/glucose (AUC-Ins/Glu) and the area under the curve C-peptide/glucose (AUC-CP/Glu). T2DM patients with osteosarcopenia had lower body mass index, waist circumference, body fat percentage, AUC-Ins/Glu, and AUC-CP/Glu. Both AUC-Ins/Glu (OR = 0.634, P = 0.008) and AUC-CP/Glu (OR = 0.491, P = 0.009) were negatively associated with the presence of osteosarcopenia. Multivariate linear regression analysis showed that β-cell function was positively associated with the skeletal muscle mass index, whereas it showed no correlation with lumbar or hip BMD. β-Cell function is associated with osteosarcopenia in middle-aged and older nonobese patients with T2DM. These findings suggest that β-cell function might be a protective factor against osteosarcopenia.

Osteosarcopenia: A Narrative Review on Clinical Studies

“…β-cell function may be implicated in this relationship, which is positively associated with skeletal muscle mass index but not with body mineral density. Liu and colleagues [ 54 ] investigated the association between OS and β-cell function, as well as insulin resistance in patients with T2DM in a sample of 150 non-obese subjects aged ≥50 years. The results show that diabetic patients with OS have lower BMI, waist circumference, body fat percentage, and worse β-cell function.…”

Profile of a patient with stable coronary artery disease and impaired muscle status

“…И хотя в настоящее время доступен весьма широкий спектр визуализирующих, функциональных и биологических маркеров саркопении, объективное измерение показателей саркопении затрудняется ограничениями, присущими всем диагностическим инструментам, и отсутствием единых методологических подходов [8]. Наибольшее распространение в количественной оценке мышечной ткани получил подход с определением площади всех поперечнополосатых мышц по данным КТ брюшной полости [9] [14]. В дополнение к портрету пациента со стабильной ИБС и сопутствующей саркопенией следует добавить дислипидемию.…”