β cell aging and age-related diabetes

Zhu, Min; Liu, Xiaohong; Li, Wen; Liu, Yanrong; Cheng, Jun; Chen, Younan

doi:10.18632/aging.202593

Cited by 40 publications

(23 citation statements)

References 100 publications

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“…The participants’ average age in the present study (61.14 ± 6.06 years) was much higher than the IRAS (54.4 ± 0.32) 10 , Daqing (44.7 ± 0.4) 11 and DPP studies (50.6 ± 10.7) 12 . The effects of increasing insulin resistance and impaired pancreatic islet function with aging might contribute to the consequent risk of diabetes 13 , 14 . Furthermore, in the IRAS study, together with impaired glucose tolerance patients, people with normal glucose tolerance were also included in the study, which would obviously dilute its incidence of diabetes.…”

Section: Discussionmentioning

confidence: 99%

β‐Cell function and body mass index are predictors of exercise response in elderly patients with prediabetes

Feng

Shi

et al. 2022

J of Diabetes Invest

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Aims/Introduction To explore the predicting factors of exercise response (whether the participants converted to diabetes) in elderly patients with prediabetes. Materials and Methods This is a retrospective subgroup analysis of the registered clinical trial with previous publication of the same cohort. A total of 248 participants with prediabetes were randomized to the aerobic training ( n = 83) group, resistance training ( n = 82) group and control group ( n = 83). The patients who finished the 2‐year exercise intervention were included in this analysis to explore the factors impacting exercise response. Results A total of 113 patients with prediabetes completed 2 years of exercise, with 56 participants in the aerobic exercise group and 57 in the resistance exercise group. Patients who reversed to normal glucose tolerance, remained in prediabetes and developed diabetes were 18 (15.90%), 70 (62.00%) and 25 (22.10%), respectively. Logistic regression showed that baseline, homeostatic model 2 assessment of β‐cell function (β = −0.143, P = 0.039), hemoglobin A1c (β = 3.301, P = 0.007) and body mass index (β = 0.402, P = 0.012) were related to exercise response, whereas the waist‐to‐hip ratio (β = −3.277, P = 0.693) and types of exercise (β = 1.192, P = 0.093) were not significantly related to exercise response. Conclusions Baseline homeostatic model 2 assessment of β‐cell function, hemoglobin A1c and body mass index were the predictors for the response to exercise in elderly patients with prediabetes.

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Section: Discussionmentioning

confidence: 99%

β‐Cell function and body mass index are predictors of exercise response in elderly patients with prediabetes

Feng

Shi

et al. 2022

J of Diabetes Invest

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“…The main physio-pathological process of T2DM is the state of sustained hyperglycaemia attributed to pancreatic β-cells impaired insulin secretion or/and cell insulin resistance [60]. The major role played by MedDiet is related to its glucometabolic benefits, including improvements in insulin resistance, insulin clearance, and β-cell function [61], which are possibly influenced by several factors including aging or genetic abnormalities [62]. In this regard, glucolipotoxicity [63], reactive oxygen stress [64], insulin resistance [62], activation of inflammatory pathways [65], amongst others, contribute to β-cell impaired insulin secretion.…”

Section: Type 2 Diabetes Mellitusmentioning

confidence: 99%

“…The major role played by MedDiet is related to its glucometabolic benefits, including improvements in insulin resistance, insulin clearance, and β-cell function [61], which are possibly influenced by several factors including aging or genetic abnormalities [62]. In this regard, glucolipotoxicity [63], reactive oxygen stress [64], insulin resistance [62], activation of inflammatory pathways [65], amongst others, contribute to β-cell impaired insulin secretion. Improved glycaemic control is fundamental in T2DM complications prevention in both acute and chronic conditions.…”

Section: Type 2 Diabetes Mellitusmentioning

confidence: 99%

Application of Mediterranean Diet in Cardiovascular Diseases and Type 2 Diabetes Mellitus: Motivations and Challenges

et al. 2022

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Objective: Cardiovascular disease (CVD) is the leading cause of disability and death in many countries. Together with CVD, Type 2 diabetes mellitus (T2DM) accounts for more than 80% of all premature non-communicable disease deaths. The protective effect of the Mediterranean diet (MedDiet) on CVD and its risk factors, including T2DM, has been a constant topic of interest. Notwithstanding, despite the large body of evidence, scientists are concerned about the challenges and difficulties of the application of MedDiet. This review aims to explore the motivations and challenges for using MedDiet in patients with CVD and T2DM. Design: An electronic search was conducted for articles about MedDiet published in PubMed, ScienceDirect, Scopus, and Web of Science up to December 2021, particularly on CVD and T2DM patients. From a total of 1536 studies, the final eligible set of 108 studies was selected. Study selection involved three iterations of filtering. Results: Motivation to apply MedDiet was driven by the importance of studying the entire food pattern rather than just one nutrient, the health benefits, and the distinct characteristics of MedDiet. Challenges of the application of MedDiet include lacking universal definition and scoring of MedDiet. Influences of nutritional transition that promote shifting of traditional diets to Westernized diets further complicate the adherence of MedDiet. The challenges also cover the research aspects, including ambiguous and inconsistent findings, the inexistence of positive results, limited evidence, and generalization in previous studies. The review revealed that most of the studies recommended that future studies are needed in terms of health benefits, describing the potential benefits of MedDiet, identifying the barriers, and mainly discussing the effect of MedDiet in different populations. Conclusions: In general, there is consistent and strong evidence that MedDiet is associated inversely with CVD risk factors and directly with glycemic control. MedDiet is the subject of active and diverse research despite the existing challenges. This review informs the health benefits conferred by this centuries-old dietary pattern and highlights MedDiet could possibly be revolutionary, practical, and non-invasive approach for the prevention and treatment CVD and T2DM.

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“…This implies that yoga practice can effectively relieve the aforementioned pre-diabetes features. The aging process increases cellular stress and damage in pancreatic β cells, thereby reducing the insulin secretion capacity of β cells and increasing insulin resistance, leading to dysregulation of glucose control and age-related diabetes [ 43 ]. Therefore, glycemic control is critical for older adults.…”

Section: Potential Effects Of Mbi On Glycemic Controlmentioning

confidence: 99%

Utilization of Mind–Body Intervention for Integrative Health Care of COVID-19 Patients and Survivors

Yang

Setou

Koh

2022

IJERPH

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Recent findings suggest a correlation between COVID-19 and diabetes, although the underlying causes are still little understood. COVID-19 infection tends to induce severe symptoms in patients with underlying diabetes, increasing their mortality rate. Moreover, COVID-19 itself appears to be a diabetogenic factor. In addition, mental health conditions, such as depression due to lockdown and anxiety about infection, were found to affect glycemic control and immunity, highlighting the importance of mental health care during the pandemic. Mind–Body Intervention (MBI), which includes meditation, yoga, and qigong, has emerged as a tool for mental health management due to its effects on stress reduction and the promotion of mental and physical well-being. Here, we review the latest randomized controlled trials to determine the effects of MBI on glycemic control and the immune system and discuss the underlying mechanisms by which MBI facilitates the virtuous cycle of stress management, glycemic control, and immune modulation. Furthermore, we examine the actual utilization of MBI during the COVID-19 pandemic era through recent studies. With proper online education, non-pharmacological MBI may be more widely used as an important tool for self-health care that complements the usual treatment of COVID-19 patients and survivors.

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β cell aging and age-related diabetes

Cited by 40 publications

References 100 publications

β‐Cell function and body mass index are predictors of exercise response in elderly patients with prediabetes

β‐Cell function and body mass index are predictors of exercise response in elderly patients with prediabetes

Application of Mediterranean Diet in Cardiovascular Diseases and Type 2 Diabetes Mellitus: Motivations and Challenges

Utilization of Mind–Body Intervention for Integrative Health Care of COVID-19 Patients and Survivors

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