β-catenin Overexpression in the Nucleus Predicts Progress Disease and Unfavourable Survival in Colorectal Cancer: A Meta-Analysis

Chen, Zhigang; He, Xin; Jia, Minyue; Liu, Yang; Qu, Daofeng; Wu, Dang; Wu, Pin; Ni, Chao; Zhang, Zhigang; Ye, Jun; Xu, Jinghong; Huang, Jian

doi:10.1371/journal.pone.0063854

Cited by 61 publications

(59 citation statements)

References 37 publications

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“…Numerous studies have reported that β-catenin overexpression in the cytoplasm and/or nucleus is correlated with cancer metastasis and poor prognosis (43)(44)(45)(46)(47)(48)(49)(50)(51). In the present study, higher Edmondson grade, poor TNM stage and positive portal vein invasion cases were identified to have increased cytoplasmic expression of β-catenin.…”

Section: Fak β-Catenin C-met Clinicopathological --------------------supporting

confidence: 56%

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Prognostic significance of c-Met, β-catenin and FAK in patients with hepatocellular carcinoma following surgery

Gong

et al. 2018

Oncol Lett

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Abstract. The present study aimed to investigate the prognostic value of specific molecular markers in patients with hepatocellular carcinoma (HCC) who had received surgery. Immunohistochemical analysis was used to measure the expression of hepatocyte growth factor receptor (c-Met), β-catenin and focal adhesion kinase (FAK) in patients with HCC. c-Met expression was identified to be high in patients with larger tumors, higher α-fetoprotein (AFP) levels, higher Edmondson grades, portal vein invasion and higher tumor-node-metastasis (TNM) stages. FAK expression was high in patients with portal vein invasion, higher Edmondson grades and higher TNM stages. β-catenin expression was high in patients with larger tumors, hepatitis B virus (HBV) infection, portal vein invasion, higher Edmondson grades and higher TNM stages. Following multivariate analysis, FAK (P= 0.002) and β-catenin (P= 0.006) expression levels were demonstrated to be significantly associated with Edmondson grade. Additionally, the tumor size (P= 0.009) and HBV infection status (P= 0.002) were revealed to be associated with β-catenin expression. Kaplan-Meier survival curve analysis demonstrated that patients with HCC with higher FAK expression, higher β-catenin expression, portal vein invasion, higher Edmondson grades, higher TNM stages, younger ages and higher AFP levels had significantly poorer prognoses. Cox's regression analysis revealed that the survival period was correlated with the Edmondson grade, age, AFP level, and FAK and β-catenin expression. Univariate analysis of c-Met, β-catenin and FAK identified a significant correlation between FAK and β-catenin (P= 0.015). Correlation analysis revealed no significant correlation between the three molecular markers, but β-catenin and c-Met were markedly correlated (P=0.052). No significant correlation between FAK, c-Met or β-catenin expression was identified. FAK and β-catenin expression demonstrated a correlation with a range of clinicopathological factors, and high FAK and β-catenin expression levels were identified to be correlated with a poor survival rate of patients with HCC. Thus, patients with higher FAK and β-catenin expression may require more aggressive therapy. The results of the present study suggest that FAK and β-catenin expression possess more prognostic value than c-Met expression in patients with HCC.

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Section: Fak β-Catenin C-met Clinicopathological --------------------supporting

confidence: 56%

“…β-catenin protein can be located in the cell membrane, cytoplasm or nucleus (43). In inactivated cells, the majority of β-catenin is primarily located in the membrane and integrated into the adhesion complex, which is responsible for maintaining cell junctions.…”

Section: Fak β-Catenin C-met Clinicopathological --------------------mentioning

confidence: 99%

Prognostic significance of c-Met, β-catenin and FAK in patients with hepatocellular carcinoma following surgery

Gong

et al. 2018

Oncol Lett

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“…Moreover, β-catenin is also important in Wnt signaling pathway, which was involved , Ke-Hu Yang 1 * with the transcription of Wnt target genes resulting in cell proliferation, invasion, and metastasis (Nelson et al, 2004;Barker et al, 2006;Wang et al, 2012;Pandurangan et al, 2013). It has been reported that aberrant expression of β-catenin was associated with the poor prognosis of non-small cell lung cancer (NSCLC) (Mei et al, 2013), and colorectal cancer (CRC) (Chen et al, 2013). Many studies also reported that β-catenin was involved in the development of EC, however, its prognostic significance for EC patients remains controversial (Krishnadath et al, 1997;Shiozaki et al, 2000;Hsu et al, 2008;Lin et al, 2008;Li et al, 2009;Nozoe et al, 2009;Situ et al, 2010;Chen et al, 2011;Wang et al, 2011;Lv et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Prognostic Significance of Beta-Catenin Expression in Patients with Esophageal Carcinoma: a Meta-analysis

Zeng

Duan²,

Kong³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Many studies have reported β-catenin involvement in the development of esophageal carcinoma (EC), but its prognostic significance for EC patients remains controversial. Therefore, we conducted this meta-analysis to explore the issue in detail. After searching PubMed, EMBASE, Web of Science, and Chinese Biomedical Literature Database, we included a total of ten relevant studies. We pooled the overall survival (OS) data using RevMan 5.2 software. The results showed that aberrant expression of β-catenin was associated with a significant increase of mortality risk (hazard ratio 1.71, 95%CI 1.46-2.01; p<0.00001). Subgroup analyses further suggested that aberrant expression of β-catenin resulted in poor OS of EC patients regardless of histological type of EC, study location or criteria for aberrant expression of β-catenin, and the sensitivity analyses revealed that the result was robust. The meta-analysis revealed that aberrant expression of β-catenin could be a predicative factor of poor prognosis for EC patients.

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“…20 The translocation of b-catenin into the nucleus might be associated with T-cell factor to form a functional transcription factor that can mediate the transactivation of target genes involved in tumor progression, invasion, and metastasis. 21 In this study, we investigated the expression pattern of SATB1 and its correlation with clinicopathological parameters in a Chinese CRC cohort.…”

Section: Introductionmentioning

confidence: 99%

SATB1 expression is correlated with β-catenin associated epithelial–mesenchymal transition in colorectal cancer

Wang

Shen

et al. 2016

Cancer Biology & Therapy

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SATB1, a global gene regulator, has been implicated in the growth and metastasis of multiple cancers, including colorectal cancer. While the understanding about the role of SATB1 in CRC remains limited. The aim of our study is to investigate the expression of SATB1 in CRC, and the relationship between SATB1 expression pattern and clinicopathological variables. A further aim is to analyze the correlation between SATB1 expression and epithelial-mesenchymal transition in CRC. Immunohistochemical expression of SATB1, b-catenin, E-cadherin, CK20, Vimentin, SMA, and desmin were assessed in a cohort of 200 patients using tissue microarrays. SATB1 was expressed in 133 (66.5%) CRC primary lesions, 14 (28%) adjacent colorectal mucosa specimens, and 60 (75%) corresponding lymph node metastases. The expression level of SATB1 was significantly higher in lymph node metastases than in CRC primary lesions and normal mucosa (P D 0.000). High expression of SATB1 in CRC was strongly correlated with poor differentiation of tumor tissues (P D 0.000). High expression of SATB1 was significantly correlated with aberrant expression of b-catenin (P D 0.0005), low expression of E-cadherin (P D 0.000) and CK20 (P D 0.000) and with high expression of Vimentin (P D 0.001). No SMA or desmin protein was expressed in the CRC cells. Our results suggested that high expression of SATB1 is significantly correlated with poor differentiation of CRC. SATB1 might promote the epithelial-mesenchymal transition by increasing the aberrant expression of b-catenin.

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β-catenin Overexpression in the Nucleus Predicts Progress Disease and Unfavourable Survival in Colorectal Cancer: A Meta-Analysis

Cited by 61 publications

References 37 publications

Prognostic significance of c-Met, β-catenin and FAK in patients with hepatocellular carcinoma following surgery

Prognostic significance of c-Met, β-catenin and FAK in patients with hepatocellular carcinoma following surgery

Prognostic Significance of Beta-Catenin Expression in Patients with Esophageal Carcinoma: a Meta-analysis

SATB1 expression is correlated with β-catenin associated epithelial–mesenchymal transition in colorectal cancer

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