β-Catenin Activation Regulates Tissue Growth Non–Cell Autonomously in the Hair Stem Cell Niche

Deschene, Elizabeth R.; Myung, Peggy; Rompolas, Panteleimon; Zito, Giovanni; Sun, Thomas; Taketo, Makoto Mark; Saotome, Ichiko; Greco, Valentina

doi:10.1126/science.1248373

Cited by 102 publications

(115 citation statements)

References 37 publications

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“…This proliferation is brief: Soon, the TACs (and their Shh signal) and the DP (and their BMP inhibitory signals) move too far away from the stem cell niche, which then returns to quiescence (Hsu et al 2011(Hsu et al , 2014. Intriguingly, when b-catenin levels are artificially high in transgenic HFSCs, they stimulate the proliferation of neighboring HFSCs non-cell-autonomously (Deschene et al 2014). Given that Shh activation is a downstream event of Wnt signaling in the hair follicle, it will be interesting to see whether this phenomena entails the same mechanism as described by Hsu et al (2014).…”

Section: Wnt/b-catenin Signaling In Balancing Growth and Differentiatmentioning

confidence: 99%

Wnt some lose some: transcriptional governance of stem cells by Wnt/β-catenin signaling

2014

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In mammals, Wnt/b-catenin signaling features prominently in stem cells and cancers, but how and for what purposes have been matters of much debate. In this review, we summarize our current knowledge of Wnt/b-catenin signaling and its downstream transcriptional regulators in normal and malignant stem cells. We centered this review largely on three types of stem cells-embryonic stem cells, hair follicle stem cells, and intestinal epithelial stem cells-in which the roles of Wnt/b-catenin have been extensively studied. Using these models, we unravel how many controversial issues surrounding Wnt signaling have been resolved by dissecting the diversity of its downstream circuitry and effectors, often leading to opposite outcomes of Wnt/b-catenin-mediated regulation and differences rooted in stage-and context-dependent effects.

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Section: Wnt/b-catenin Signaling In Balancing Growth and Differentiatmentioning

confidence: 99%

Wnt some lose some: transcriptional governance of stem cells by Wnt/β-catenin signaling

2014

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“…Controlled short-range Wnt signaling from supporting cells maintains stem cell fate and allows the differentiation of more distant cells in the intestinal niche (Sato et al, 2011). In the hair stem cell niche, Wnt signaling has been shown to alter the axis of division of bulge stem cells to generate a new hair follicle (Deschene et al, 2014). All of these examples require a tight control of the signaling range as well as the subcellular induction of Wnt signaling in order to regulate asymmetric stem cell division.…”

Section: Cytonemes In the Stem Cell Nichementioning

confidence: 99%

Role of cytonemes in Wnt transport

Stanganello

Scholpp

2016

Journal of Cell Science

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Wnt signaling regulates a broad variety of processes during embryonic development and disease. A hallmark of the Wnt signaling pathway is the formation of concentration gradients by Wnt proteins across responsive tissues, which determines cell fate in invertebrates and vertebrates. To fulfill its paracrine function, trafficking of the Wnt morphogen from an origin cell to a recipient cell must be tightly regulated. A variety of models have been proposed to explain the extracellular transport of these lipid-modified signaling proteins in the aqueous extracellular space; however, there is still considerable debate with regard to which mechanisms allow the precise distribution of ligand in order to generate a morphogenetic gradient within growing tissue. Recent evidence suggests that Wnt proteins are distributed along signaling filopodia during vertebrate and invertebrate embryogenesis. Cytoneme-mediated transport has profound impact on our understanding of how Wnt signaling propagates through tissues and allows the formation of a precise ligand distribution in the recipient tissue during embryonic growth. In this Commentary, we review extracellular trafficking mechanisms for Wnt proteins and discuss the growing evidence of cytoneme-based Wnt distribution in development and stem cell biology. We will also discuss their implication for Wnt signaling in the formation of the Wnt morphogenetic gradient during tissue patterning.

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“…In addition, dermal adipocytes secrete antimicrobial peptides to protect the skin from bacterial infection, thereby playing a role in the skin's innate immunity (Zhang et al 2015). Ectopic activation of β-catenin in the epithelial compartment affects several aspects of skin biology, including hair cycle, dermal fibroblasts, and adipose layer thickness (Deschene et al 2014;Donati et al 2014;Kretzschmar et al 2016;Lichtenberger et al 2016), suggesting that dermal changes are sensitive to alterations in the epithelial lineage. However, the physiologically relevant factor and the specific cell types governing the coordinated changes of dermal adipose layer and hair cycle progression remain unknown.…”

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confidence: 99%

Hair follicles’ transit-amplifying cells govern concurrent dermal adipocyte production through Sonic Hedgehog

Zhang¹,

Tsai

Gonzalez-Celeiro

et al. 2016

Genes Dev.

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Growth and regeneration of one tissue within an organ compels accommodative changes in the surrounding tissues. However, the molecular nature and operating logic governing these concurrent changes remain poorly defined. The dermal adipose layer expands concomitantly with hair follicle downgrowth, providing a paradigm for studying coordinated changes of surrounding lineages with a regenerating tissue. Here, we discover that hair follicle transitamplifying cells (HF-TACs) play an essential role in orchestrating dermal adipogenesis through secreting Sonic Hedgehog (SHH). Depletion of Shh from HF-TACs abrogates both dermal adipogenesis and hair follicle growth. Using cell type-specific deletion of Smo, a gene required in SHH-receiving cells, we found that SHH does not act on hair follicles, adipocytes, endothelial cells, and hematopoietic cells for adipogenesis. Instead, SHH acts directly on adipocyte precursors, promoting their proliferation and their expression of a key adipogenic gene, peroxisome proliferator-activated receptor γ (Pparg), to induce dermal adipogenesis. Our study therefore uncovers a critical role for TACs in orchestrating the generation of both their own progeny and a neighboring lineage to achieve concomitant tissue production across lineages.

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β-Catenin Activation Regulates Tissue Growth Non–Cell Autonomously in the Hair Stem Cell Niche

Cited by 102 publications

References 37 publications

Wnt some lose some: transcriptional governance of stem cells by Wnt/β-catenin signaling

Wnt some lose some: transcriptional governance of stem cells by Wnt/β-catenin signaling

Role of cytonemes in Wnt transport

Hair follicles’ transit-amplifying cells govern concurrent dermal adipocyte production through Sonic Hedgehog

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