β-Catenin Activates the HOXA10 and CDX4 Genes in Myeloid Progenitor Cells

Abstract

Background: HoxA10 target genes include CDX4 and FGF2, and HOXA10 is a Cdx4 target gene. Results: Transcription of newly identified, ␤-catenin-binding cis elements in the CDX4 and HOXA10 promoters is regulated by Fgf2-dependent activity of ␤-catenin. Conclusion: Positive feedback between CDX4 and HOXA10 involves ␤-catenin and Fgf2. Significance: Understanding cross-regulation between HoxA10, Cdx4, and ␤-catenin provides insights into leukemogenesis.

The Leukemia-associated Mll-Ell Oncoprotein Induces Fibroblast Growth Factor 2 (Fgf2)-dependent Cytokine Hypersensitivity in Myeloid Progenitor Cells

“…The genes encoding Cdx4 and HoxA10 are also ␤-catenin target genes, and HOXA9 and HOXA10 are Cdx4 target genes in myeloid progenitor cells (25,43). Therefore, the current studies define a positive feedback loop that leads from MLL fusion proteins to increased expression of HoxA9 and HoxA10 to autocrine production of Fgf2 and from Fgf2 back to increased expression of HoxA9 and HoxA10 through ␤-catenin and Cdx4 (Fig.…”

Low expression of BARX2 in human primary hepatocellular carcinoma correlates with metastasis and predicts poor prognosis

“…9 Homeodomain transcription factors can regulate various cellular behaviors including proliferation, differentiation, adhesion, migration and apoptosis. [12][13][14] As mentioned above, it is known that BARX2 has a critical role in regulating cell adhesion and cytoskeletal remodeling. 11 Additionally, BARX2 expression was found to be higher in normal ovarian surface epithelium than in adjacent ovarian cancer tissue, suggesting that BARX2 may function as a potential tumor progression suppressor by regulating cell adhesion, invasion and migration.…”

“…Homeodomain transcription factors can regulate various cellular behaviors including proliferation, differentiation, adhesion, migration and apoptosis . As mentioned above, it is known that BARX2 has a critical role in regulating cell adhesion and cytoskeletal remodeling .…”

HoxA10 Facilitates SHP-1-Catalyzed Dephosphorylation of p38 MAPK/STAT3 To Repress Hepatitis B Virus Replication by a Feedback Regulatory Mechanism

“…Homeobox genes encode a set of highly conserved transcription factors that are arranged in four clusters (clusters A to D), and among them, homeobox A10 (HoxA10) belongs to the A cluster (12). The homeobox domain of HoxA10 is structurally related to the helix-turn-helix motif of prokaryotic DNA-binding proteins, which regulates gene expression during differentiation and cancer progression (13). Disordered expression of HoxA10 has been found in leukemia and breast, cervical, ovarian, and pancreatic cancers (14)(15)(16).…”