β-caryophyllene cationic nanoemulsion for intranasal delivery and treatment of epilepsy: development and in vivo evaluation of anticonvulsant activity

Nogueira, Camila; Lemos‐Senna, Elenara; Vieira, Edna da Silva; Sampaio, Tuane Bazanella; Mallmann, Michele Pereira; Oliveira, Mauro Schneider; Bernardi, Luana; Oliveira, Paulo Renato de

doi:10.1007/s11051-023-05668-8

Cited by 6 publications

(6 citation statements)

References 53 publications

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“… [ 61 ] β-Caryopyllene (epilepsy) Soybean lecithin and oleylamine PS 244.03 n, PDI 0.18, and ZP +41.1 mV In the pentylenetetrazole-induced seizure model, the nanoemulsion (IN) delayed the onset of epileptic seizure compared to the control; the free drug (IN) did not show an anti-epileptic effect. [ 62 ] Liposome - DOPC, CL, and DSPE-PEG PS 89.7 nm, PDI 0.256, and ZP −18.8 mV The neutral PEGylated liposome (IN) showed a higher in-vivo brain-targeting ability than the charged and non-PEGylated liposomes (IN). [ 63 ] Ghrelin (cachexia) Soybean PC, DSPE-PEG, CL, and chitosan PS 72.25 nm, PDI 0.30, ZP +50.30 mV, and EE 53.20% The chitosan-coated liposome displayed higher permeation and bioadhesive properties.…”

Section: Strategies To Improve Drug Delivery Via the Intranasal Routementioning

confidence: 99%

“… 87 Commonly utilized oils in the nanoemulsions encompass coconut oil, cottonseed oil, safflower oil, sesame oil, and soybean oil, often blended in varying proportions. 62 The oil selection can directly impact the bioavailable fraction of the active component. Surfactants, characterized by their amphiphilic nature, play a pivotal role in stabilizing nanoemulsions by reducing interfacial tension and preventing droplet aggregation.…”

Section: Strategies To Improve Drug Delivery Via the Intranasal Routementioning

confidence: 99%

“…Surfactants, characterized by their amphiphilic nature, play a pivotal role in stabilizing nanoemulsions by reducing interfacial tension and preventing droplet aggregation. 62 Examples of surfactants are sodium deoxycholate, Cremophor ® EL, Tween ® (polyoxyethylene sorbitan monolaurate), Span ® (sorbitan monolaurate), Solutol ® HS 15 (polyoxyethylene-660-hydroxystearate), Poloxamer ® , and sodium dodecyl sulfate. 62 The choice of a surfactant not only influences the size and stability of the nanoemulsion but also affects its toxicity, pharmacokinetics, and pharmacodynamics.…”

Section: Strategies To Improve Drug Delivery Via the Intranasal Routementioning

confidence: 99%

“… 62 Examples of surfactants are sodium deoxycholate, Cremophor ® EL, Tween ® (polyoxyethylene sorbitan monolaurate), Span ® (sorbitan monolaurate), Solutol ® HS 15 (polyoxyethylene-660-hydroxystearate), Poloxamer ® , and sodium dodecyl sulfate. 62 The choice of a surfactant not only influences the size and stability of the nanoemulsion but also affects its toxicity, pharmacokinetics, and pharmacodynamics. 62 In nose-to-brain delivery systems, nanoemulsions can overcome the limitations of drugs, such as poor bioavailability and water insolubility.…”

Section: Strategies To Improve Drug Delivery Via the Intranasal Routementioning

confidence: 99%

“… 62 The choice of a surfactant not only influences the size and stability of the nanoemulsion but also affects its toxicity, pharmacokinetics, and pharmacodynamics. 62 In nose-to-brain delivery systems, nanoemulsions can overcome the limitations of drugs, such as poor bioavailability and water insolubility. 87 , 88 In addition, their lipophilic nature and small particle size enhance uptake across the nasal mucosa, protecting the encapsulated drugs from biological and chemical degradation.…”

Section: Strategies To Improve Drug Delivery Via the Intranasal Routementioning

confidence: 99%

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Recent Advances in Intranasal Administration for Brain-Targeting Delivery: A Comprehensive Review of Lipid-Based Nanoparticles and Stimuli-Responsive Gel Formulations

Koo,

Lim,

2024

IJN

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Addressing disorders related to the central nervous system (CNS) remains a complex challenge because of the presence of the blood-brain barrier (BBB), which restricts the entry of external substances into the brain tissue. Consequently, finding ways to overcome the limited therapeutic effect imposed by the BBB has become a central goal in advancing delivery systems targeted to the brain. In this context, the intranasal route has emerged as a promising solution for delivering treatments directly from the nose to the brain through the olfactory and trigeminal nerve pathways and thus, bypassing the BBB. The use of lipid-based nanoparticles, including nano/microemulsions, liposomes, solid lipid nanoparticles, and nanostructured lipid carriers, has shown promise in enhancing the efficiency of nose-to-brain delivery. These nanoparticles facilitate drug absorption from the nasal membrane. Additionally, the in situ gel (ISG) system has gained attention owing to its ability to extend the retention time of administered formulations within the nasal cavity. When combined with lipid-based nanoparticles, the ISG system creates a synergistic effect, further enhancing the overall effectiveness of brain-targeted delivery strategies. This comprehensive review provides a thorough investigation of intranasal administration. It delves into the strengths and limitations of this specific delivery route by considering the anatomical complexities and influential factors that play a role during dosing. Furthermore, this study introduces strategic approaches for incorporating nanoparticles and ISG delivery within the framework of intranasal applications. Finally, the review provides recent information on approved products and the clinical trial status of products related to intranasal administration, along with the inclusion of quality-by-design–related insights.

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Section: Strategies To Improve Drug Delivery Via the Intranasal Routementioning

confidence: 99%

Section: Strategies To Improve Drug Delivery Via the Intranasal Routementioning

confidence: 99%

Section: Strategies To Improve Drug Delivery Via the Intranasal Routementioning

confidence: 99%

Section: Strategies To Improve Drug Delivery Via the Intranasal Routementioning

confidence: 99%

Section: Strategies To Improve Drug Delivery Via the Intranasal Routementioning

confidence: 99%

See 3 more Smart Citations

Recent Advances in Intranasal Administration for Brain-Targeting Delivery: A Comprehensive Review of Lipid-Based Nanoparticles and Stimuli-Responsive Gel Formulations

Koo,

Lim,

2024

IJN

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Drug Delivery Systems

Azagury,

Kaeek,

Khoury

et al. 2023

Kirk-Othmer Encyclopedia of Chemical Technology

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Drug delivery systems (DDSs) and their administration routes play a critical role in the efficacy and safety of drugs. There are several physiological routes for drug delivery, including oral administration, injectables, inhalation, transdermal, intranasal, and transdermal delivery. This article focuses on these administration routes, describes their advantages and disadvantages, and elaborates on triggered and targeted DDS. Additionally, this article also describes drug release mechanisms from DDSs. DDSs are classified based on their physicochemical properties and administration routes. Pulsatile/stimuli systems allow controlled drug release at a specific time or location in response to an external stimulus. In addition, the controlled DDS employs several drug release mechanisms, such as diffusion, swelling, and erosion, to achieve the desired therapeutic effect. Representative applications of DDSs include the treatment of cancer, diabetes, and cardiovascular diseases. The COVID‐19 vaccine is a significant achievement in DDS, showcasing its potential to address global health crises. It utilizes lipid nanoparticles to encapsulate and protect mRNA, enabling targeted delivery to host cells. The mRNA instructs cells to produce the spike protein of the SARS‐CoV‐2 virus, triggering an immune response for COVID‐19 protection. In conclusion, DDSs and their administration routes are vital for safe and effective drug development, with recent advances such as pulsatile/stimuli systems showing promise for targeted delivery. The COVID‐19 vaccine development demonstrates the potential of DDS in tackling global health issues.

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Beta-caryophyllene in psychiatric and neurological diseases: Role of blood-brain barrier

Mallmann,

Oliveira

2024

Blood-Brain Barrier

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β-caryophyllene cationic nanoemulsion for intranasal delivery and treatment of epilepsy: development and in vivo evaluation of anticonvulsant activity

Cited by 6 publications

References 53 publications

Recent Advances in Intranasal Administration for Brain-Targeting Delivery: A Comprehensive Review of Lipid-Based Nanoparticles and Stimuli-Responsive Gel Formulations

Recent Advances in Intranasal Administration for Brain-Targeting Delivery: A Comprehensive Review of Lipid-Based Nanoparticles and Stimuli-Responsive Gel Formulations

Drug Delivery Systems

Beta-caryophyllene in psychiatric and neurological diseases: Role of blood-brain barrier

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