β-Carotene—properties and production methods

Bogacz-Radomska, Ludmiła; Harasym, Joanna

doi:10.1093/fqsafe/fyy004

Cited by 154 publications

(86 citation statements)

References 49 publications

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“…Since, β‐Carotene has numerous biological functions in body but humans are not able to synthesize it, hence, it is necessary to supply these compounds with food or pharmaceuticals. Originally β‐carotene was recovered from plants by physicochemical extraction mainly from carrots but nowadays β‐carotene is mainly produced through chemical synthesis (Bogacz‐Radomska & Harasym, ). Monaghan and Schmitt () first described β‐carotene as a fat‐soluble vitamin A.…”

Section: Nonenzymatic Antioxidantsmentioning

confidence: 99%

Understanding oxidants and antioxidants: Classical team with new players

et al. 2020

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The free radical oxidants such as reactive oxygen species, reactive nitrogen species, and reactive sulfur species are produced inside cells through various metabolic processes. The body is equipped with an antioxidant defense system that guards against oxidative damage caused by these reactive oxidants and plays a major role in protecting cells from oxidative stress and damage. Antioxidants such as glutathione (GSH), thioredoxin, ascorbic acid and enzymes, for example, superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT) counter the oxidative stress and protect lipids, proteins, and DNA. Antioxidants such as tocopherols, ascorbic acid, carotenoids, flavonoids, amino acids are also natural antioxidants present in foods. There is increasing demand and availability of designer foods fortified with antioxidants and probiotics that may be important in human health. The review article presents a brief overview of oxidants and antioxidant systems inside the human body including the role of probiotics and inflammation. Practical applications Antioxidants such as GSH, thioredoxin, ascorbic acid, etc. and protective enzymes, for example, SOD, GPx, CAT, etc. counter oxidative stress and protect cellular biomolecules. Antioxidants such as tocopherols, ascorbic acid, carotenoids, flavonoids, amino acids, phospholipids, and sterols are natural antioxidants found in consumed foods. They play a major role in scavenging free radical and non‐radical oxidants, and protect cells from oxidative stress and damage. The importance of antioxidants can be understood from the fact that oxidative damage is now associated with a variety of diseases including cancer, neurodegeneration, diabetes, etc. Several approaches to improve human health and achieve longevity use dietary antioxidants as formulation in diet and fortified foods. Antioxidants also maintain freshness and prolonging the shelf life of food products. The fortified or designer foods that are added with antioxidant nutrients and the use of microorganisms as probiotics are increasingly available in the market as health foods and supplements.

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Section: Nonenzymatic Antioxidantsmentioning

confidence: 99%

Understanding oxidants and antioxidants: Classical team with new players

et al. 2020

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“…Carotenoids such as beta-carotene have multiple uses industrially, including for health and as a pigment [60,61]. In addition to beta-carotene as a target chemical, partially overlapping isoprenoid pathways produce other valuable chemicals such as isoprene, arteminisin, limonene, and paclitaxel (Taxol); demonstration of beta-carotene production helps open the door to these compounds as well [27,[62][63][64][65][66][67].…”

Section: Heterologous Production Of Beta-carotenementioning

confidence: 99%

Exploiting the Feedstock Flexibility of the Emergent Synthetic Biology Chassis Vibrio natriegens for Engineered Natural Product Production

et al. 2019

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A recent goal of synthetic biology has been to identify new chassis that provide benefits lacking in model organisms. Vibrio natriegens is a marine Gram-negative bacterium which is an emergent synthetic biology chassis with inherent benefits: An extremely fast growth rate, genetic tractability, and the ability to grow on a variety of carbon sources ("feedstock flexibility"). Given these inherent benefits, we sought to determine its potential to heterologously produce natural products, and chose beta-carotene and violacein as test cases. For beta-carotene production, we expressed the beta-carotene biosynthetic pathway from the sister marine bacterium Vibrio campbellii, as well as the mevalonate biosynthetic pathway from the Gram-positive bacterium Lactobacillus acidophilus to improve precursor abundance. Violacein was produced by expressing a biosynthetic gene cluster derived from Chromobacterium violaceum. Not only was V. natriegens able to heterologously produce these compounds in rich media, illustrating its promise as a new chassis for small molecule drug production, but it also did so in minimal media using a variety of feedstocks. The ability for V. natriegens to produce natural products with multiple industrially-relevant feedstocks argues for continued investigations into the production of more complex natural products in this chassis.

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“…The study of the accumulation of b-carotene focused on its pharmacological properties such as anti-carcinogenic and anti-mutagenic. b-carotene an important provitamin A, which demonstrates the protective action in human organisms, for example, as powerful antioxidants (Bogacz-Radomska and Harasym, 2018). Content of b-carotene in raw of Crambe species determined from 0.387 to 2.408 mg% (Figure 4).…”

Section: Sv -Spring Vegetation; B -Budding Stage; Fl -Flowering Stagementioning

confidence: 99%

Accumulation of Nutrients in the Raw Of Crambe L. Species

Vergun

Shymanska²,

Rakhmetov³

et al. 2019

Agrobiodiversity for Improving of Nutrition, Health and Life Quality

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Investigation of accumulation of different compounds in above-ground part of these plants an important aspect for evaluation of perspective of use. The aim of this study was to compare the peculiarities of the biochemical composition of Crambe species dynamically. Plant material collected from the experimental collection of M.M. Gryshko National Botanical Garden of the NAS of Ukraine. It was studied above-ground parts of C. cordifolia Steven, C. koktebelica (Junge) N. Busch, C. maritima L., C. steveniana Rupr. At the spring vegetation, budding stage, flowering, and fruitage. Following biochemical parameters was studied: dry matter by drying to consist weight at the 105 °C; content of sugars by Bertrand's method using of glucose scale; ascorbic acids with 2.6-dichlorophenolindophenol, tannins with indigo carmine discoloration, organic acids by sodium hydroxide titration with phenolphthalein; carotene with gasoline galosh spectrophotometrically; ash in muffle over. The dry matter during vegetation was from 9.76 (C. cordifolia, budding) to 22.54 (C. maritima at the fruitage) %, total content of sugars from 6.54 (C. maritime at the fruitage) to 33.18 (C. cordifolia at the budding) %, ascorbic acid from 139.85 (C. maritima at the spring vegetation) to 987.02 (C. maritime at the budding) mg%, b-carotene from 0.39 (C. maritima at the budding) to 1.82 (C. cordifolia at the fruitage) mg%, tannins from 1.28 (C. cordifolia at the fruitage) to 7.47 (C. steveniana at the budding) %, content of organic acids from 3.12 (C. steveniana at the fruitage) to 6.28 (C. koktebelica at the spring vegetation) %, ash from 6.11 (C. maritima at the spring vegetation) to 14.61 (C. cordifolia at the flowering) %. Correlation analysis showed that between the content of tannins and organic acids existed positive moderate correlation (r = 0.52). Between other parameters found the weak, very weak positive or negative correlation. Thus, comparing biochemical analyze identified that raw of four species of Crambe is a valuable source of nutrients during vegetation. The high content of sugars, ascorbic acid, and carotene can recommend these plants as forage crops. Also, raw of these plants can be recommended for farther pharmacological investigations.

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β-Carotene—properties and production methods

Cited by 154 publications

References 49 publications

Understanding oxidants and antioxidants: Classical team with new players

Understanding oxidants and antioxidants: Classical team with new players

Exploiting the Feedstock Flexibility of the Emergent Synthetic Biology Chassis Vibrio natriegens for Engineered Natural Product Production

Accumulation of Nutrients in the Raw Of Crambe L. Species

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