β-Carotene-loaded nanostructured lipid carriers produced by solvent displacement method

Oliveira, Davi Rocha Bernardes de; Michelon, Mariano; Furtado, Guilherme de Figueiredo; Sinigaglia‐Coimbra, Rita; Cunha, Rosiane L.

doi:10.1016/j.foodres.2016.10.038

Cited by 39 publications

(21 citation statements)

References 36 publications

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“…Imbalanced ratios are not beneficial for the maximum formation of lipid carriers and can have imperfect crystals. A balanced ratio allows for a large amount of space to accommodate more bioactive substances and the ability to avoid leaking …”

Section: Resultsmentioning

confidence: 99%

“…The free amount of total β-carotene in the NLC was analyzed following a reported method with slight modifications. , A mixture of 100 μL of the 9 Z -β-carotene high-loaded NLC and 3 mL hexane was vortexed for 1 min at room temperature and centrifuged at 2500 × g for 2 min. The upper organic phase was collected, and the aqueous phase was extracted two times more.…”

Section: Methodsmentioning

confidence: 99%

“…One of the weaknesses of the encapsulation technology for carotenoids is the loading capacity (LC), which is strongly affected by the solubility of carotenoids in the oil phase; thus the quantity of the oil phase is a key determinant factor . It has been reported that lipid nanoparticles improve drug absorption and bioavailability because of their nanosize diameter and enhancing effect of lipids. , Nanostructured lipid carriers (NLCs) have attracted considerable attention as an effective delivery system with sustained-release effects and capability for industrial-scale production . The NLC system is generally from a mixture of solid and liquid lipids and is normally first heated until melted down and then cooled to form a large amount of imperfect crystals and amorphous lipid cores and incorporate more drugs .…”

Section: Introductionmentioning

confidence: 99%

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Preparation of 9Z-β-Carotene and 9Z-β-Carotene High-Loaded Nanostructured Lipid Carriers: Characterization and Storage Stability

Yang

Yan

Jiang

et al. 2020

J. Agric. Food Chem.

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Cis (Z)-β-carotenes with 25.3% 9Z-β-carotene were prepared for nanostructured lipid carriers (NLCs). The optimal conditions for NLC preparation using an orthogonal experimental method were as follows: the total lipid concentration was 9% (w/v), the surfactant concentration was 1.4% (w/v), the solid to liquid lipid ratio was 3:1 (w/w), and the homogenization pressure was set at 500 bar for three cycles. Under these conditions, the encapsulation efficiency (%) of the NLC was 95.64%, and the total β-carotene in NLCs was 2.9 mg/mL, which was significantly higher than those reported by others. The proportion of total Z-β-carotenes was as high as 53.3%, the particle size was 191 ± 6.46 nm, and the polydispersity index was 0.2 ± 0.03. Storage stability results indicated that the β-carotene-loaded NLC stabilizes both 9Z-β-carotene and total β-carotene from leakage and degradation during 21 days of storage at pH 3.5–7.5 at low temperatures (4 °C), especially for the more bioactive 9Z-β-carotene. The technique with an improved ratio of 9Z-β-carotene, loading capacity, water solubility, and bioaccessibility of the β-carotene NLC provides an effective strategy for β-carotene applications in functional foods or beverages and in nutraceutical preparations.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Preparation of 9Z-β-Carotene and 9Z-β-Carotene High-Loaded Nanostructured Lipid Carriers: Characterization and Storage Stability

Yang

Yan

Jiang

et al. 2020

J. Agric. Food Chem.

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“…Current literature reports use various fabrication methods for NLCs including, highpressure homogenization at high or low temperatures (including cold homogenization and hot homogenization) [335], solvent emulsification-diffusion techniques [331], supercritical fluids (supercritical fluid extraction of emulsion) [336], solvent emulsification evaporation [335], solvent displacement [135], solvent diffusion [337], phase inversion [338,339], melt emulsification [340], sonication [334], spray-drying [340,341], and solvent evaporation [335].…”

Section: Nanostructured Lipid Carriers (Nlcs)mentioning

confidence: 99%

Fate of β-Carotene within Loaded Delivery Systems in Food: State of Knowledge

et al. 2021

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Nanotechnology has opened new opportunities for delivering bioactive agents. Their physiochemical characteristics, i.e., small size, high surface area, unique composition, biocompatibility and biodegradability, make these nanomaterials an attractive tool for β-carotene delivery. Delivering β-carotene through nanoparticles does not only improve its bioavailability/bioaccumulation in target tissues, but also lessens its sensitivity against environmental factors during processing. Regardless of these benefits, nanocarriers have some limitations, such as variations in sensory quality, modification of the food matrix, increasing costs, as well as limited consumer acceptance and regulatory challenges. This research area has rapidly evolved, with a plethora of innovative nanoengineered materials now being in use, including micelles, nano/microemulsions, liposomes, niosomes, solidlipid nanoparticles, nanostructured lipids and nanostructured carriers. These nanodelivery systems make conventional delivery systems appear archaic and promise better solubilization, protection during processing, improved shelf-life, higher bioavailability as well as controlled and targeted release. This review provides information on the state of knowledge on β-carotene nanodelivery systems adopted for developing functional foods, depicting their classifications, compositions, preparation methods, challenges, release and absorption of β-carotene in the gastrointestinal tract (GIT) and possible risks and future prospects.

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“…Current literature reports use of various fabrication methods for NLCs including, high pressure homogenization at high or low temperatures (including cold homogenization and hot homogenization) [258], solvent emulsification-diffusion techniques [251], use of supercritical fluid (supercritical fluid extraction of emulsion) [259], solvent emulsification evaporation [258], solvent displacement [260], solvent diffusion [261], phase inversion [262,263], melt emulsification [264], sonication [257], spray drying [264,265], and solvent evaporation [258].…”

Section: Nanostructured Lipid Carriers (Nlc)mentioning

confidence: 99%

Fate of β-Carotene within Loaded Delivery Systems in Food: State of Knowledge

Maurya¹,

Shakya²,

Aggarwal³

et al. 2021

Preprint

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Accruing evidence on the influence of β-carotene regarding the prevention of several chronic diseases - in addition to its well-acknowledged role in vision has been a strong driver for developing alternative delivery systems. Though oral delivery is accepted as the most fitting, mild and safe path for delivering bioactive agents, β-carotene delivery via food items poses challenges due to its lipophilic nature, poor water-solubility, high chemical/photochemical instability and poor oral bioavailability. Nanotechnology has opened new windows for delivering bioactive agents. Their physiochemical characteristics, i.e. small size, high surface area, unique composition, biocompatibility and biodegradability make these nanomaterials an attractive tool for β-carotene delivery. Delivering β-carotene through nanoparticles does not only improve its bioavailability/bioaccumulation in target tissues, but also lessens its sensitivity against environmental factors during processing. Regardless of these benefits, nanocarriers inherit some limitations, such as variations in sensory quality, modification of the food matrix, increasing costs, as well as limited consumer acceptance and regulatory challenges. This research area has been rapidly evolved, with a plethora of innovative nano-engineered materials, including micelles, nano/microemulsion, liposomes, niosomes, solid-lipid nanoparticles and nanostructured lipid carriers. These nano-delivery systems make conventional delivery systems appear archaic and promise better solubilization, protection during processing, improved shelf-life, higher bioavailability as well as controlled and targeted release. This review provides information on the state of knowledge on β-carotene nano-delivery systems adopted for developing functional foods: depicting their classification, composition, preparation methods, challenges, release-and absorption of β-carotene in the GIT and possible risks and future prospects.

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β-Carotene-loaded nanostructured lipid carriers produced by solvent displacement method

Cited by 39 publications

References 36 publications

Preparation of 9Z-β-Carotene and 9Z-β-Carotene High-Loaded Nanostructured Lipid Carriers: Characterization and Storage Stability

Preparation of 9Z-β-Carotene and 9Z-β-Carotene High-Loaded Nanostructured Lipid Carriers: Characterization and Storage Stability

Fate of β-Carotene within Loaded Delivery Systems in Food: State of Knowledge

Fate of β-Carotene within Loaded Delivery Systems in Food: State of Knowledge

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