β‐Carotene during the suckling period is absorbed intact and induces retinoic acid dependent responses similar to preformed vitamin A in intestine and liver, but not adipose tissue of young rats

Mušinović, Hana; Bonet, M. Luisa; Granados, Nuria; Amengual, Jaume; Lintig, Johannes von; Ribot, Joan; Palou, Andreu

doi:10.1002/mnfr.201400457

Cited by 18 publications

(12 citation statements)

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“…It has previously been shown that Mest expression in WAT was significantly increased already after 2 days of HFD feeding (Nikonova et al 2008). In rats, dietary treatments during the suckling period that differentially affected inguinal adipocyte size at weaning also affected Mest gene expression of the same depot similarly (Musinovic et al 2014). Differences in Mest gene expression observed in mouse WAT biopsies at an early age correlated with adiposity after 8 weeks of HFD feeding in mice (Koza et al 2006).…”

Section: Discussionmentioning

confidence: 92%

Identification of Mest/Peg1 gene expression as a predictive biomarker of adipose tissue expansion sensitive to dietary anti-obesity interventions

et al. 2015

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Food components with anti-obesity properties are commonly evaluated using mouse models of diet-induced obesity. The ability of these components to reduce or prevent white adipose tissue (WAT) accumulation is usually tested in feeding trials of several weeks duration in order to detect significant effects on fat mass expansion. Here, we aimed to identify early, predictive biomarkers for WAT expansion. We performed a 5-day high-fat diet (HFD) feeding trial with C57BL/6J mice using different established anti-obesity interventions: epigallocatechin gallate, replacing dietary lipids by n-3 PUFA, and increasing dietary protein. WAT gene expression was analyzed of genes known to be similarly affected by shortand long-term HFD. Gene expression of Leptin and Mest (mesoderm-specific transcript) was increased by HFD and normalized by all anti-obesity interventions. In a second experiment, translatability to whole blood-based expression data was assessed. Mice were challenged for 21 days with a HFD without or with simultaneous treatment with anti-obesity bioactives, hydroxytyrosol or resveratrol, and compared for parameters including Leptin and Mest expression in whole blood at day 5. While Leptin mRNA could not be detected in mouse whole blood, there was an induction of Mest mRNA by HFD which was suppressed by hydroxytyrosol. Moreover, Mest expression in whole blood at day 5 positively correlated with adiposity and negatively with lean body mass and the subcutaneous/visceral fat ratio at day 21. We conclude that gene expression of Leptin and Mest in WAT and of Mest in whole blood represent early, predictive markers of adipose tissue expansion of potential usefulness in nutritional studies and trials.Keywords Obesity Á Whole blood Á Mesoderm-specific transcript (Mest/Peg1) Á Epigallocatechin gallate (EGCG) Á n-3 PUFA Á High-protein diet Á Hydroxytyrosol Á Resveratrol

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Section: Discussionmentioning

confidence: 92%

Identification of Mest/Peg1 gene expression as a predictive biomarker of adipose tissue expansion sensitive to dietary anti-obesity interventions

et al. 2015

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“…However, even following mild acute or chronic oral β-carotene supplementation, some β-carotene is absorbed intact in adult rodents, as revealed by accumulation in tissues [325,395]. In young (suckling) rats, absorption of intact β-carotene occurs even at lower dietary doses, probably due to their immature intestine [396]. In humans and other species such as horses and ferrets about 17%-45% of the ingested β-carotene escapes intestinal cleavage, is incorporated into chylomicrons and is found associated with circulating lipoproteins.…”

Section: Absorptionmentioning

confidence: 99%

A global perspective on carotenoids: Metabolism, biotechnology, and benefits for nutrition and health

Rodríguez‐Concepción

Ávalos

Bonet

et al. 2018

Progress in Lipid Research

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Carotenoids are lipophilic isoprenoid compounds synthesized by all photosynthetic organisms and some non-photosynthetic prokaryotes and fungi. With some notable exceptions, animals (including humans) do not produce carotenoids de novo but take them in their diets. In photosynthetic systems carotenoids are essential for photoprotection against excess light and contribute to light harvesting, but perhaps they are best known for their properties as natural pigments in the yellow to red range. Carotenoids can be associated to fatty acids, sugars, proteins, or other compounds that can change their physical and chemical properties and influence their biological roles. Furthermore, oxidative cleavage of carotenoids produces smaller molecules such as apocarotenoids, some of which are important pigments and volatile (aroma) compounds. Enzymatic breakage of carotenoids can also produce biologically active molecules in both plants (hormones, retrograde signals) and animals (retinoids). Both carotenoids and their enzymatic cleavage products are associated with other processes positively impacting human health. Carotenoids are widely used in the industry as food ingredients, feed additives, and supplements. This review, contributed by scientists of complementary disciplines related to carotenoid research, covers recent advances and provides a perspective on future directions on the subjects of carotenoid metabolism, biotechnology, and nutritional and health benefits.

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“…[10][11][12] The early postnatal period might be particularly important for the programming of the browning potential of WAT, which, in rodents, mainly develops during this stage, whereas BAT develops mostly during late intrauterine life. [13] Studies on the impact of specific micronutrients and food bioactives, such as polyphenols [14][15][16][17] or vitamin A, [18,19] on the metabolic programming of adipose tissue features remain scarce. Nicotinamide riboside (NR), a B3 vitamin and NAD + precursor, and the dietary polyphenol resveratrol (RSV; 3,5,4trihydroxy-trans-stilbene) both have anti-obesity actions in adult rodents through BAT activation, [20][21][22][23][24] and, for RSV, also via WAT browning.…”

Section: Introductionmentioning

confidence: 99%

Programming of the Beige Phenotype in White Adipose Tissue of Adult Mice by Mild Resveratrol and Nicotinamide Riboside Supplementations in Early Postnatal Life

Serrano

Asnani-Kishnani

Rodríguez

et al. 2018

Molecular Nutrition Food Res

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β‐Carotene during the suckling period is absorbed intact and induces retinoic acid dependent responses similar to preformed vitamin A in intestine and liver, but not adipose tissue of young rats

Cited by 18 publications

References 49 publications

Identification of Mest/Peg1 gene expression as a predictive biomarker of adipose tissue expansion sensitive to dietary anti-obesity interventions

Identification of Mest/Peg1 gene expression as a predictive biomarker of adipose tissue expansion sensitive to dietary anti-obesity interventions

A global perspective on carotenoids: Metabolism, biotechnology, and benefits for nutrition and health

Programming of the Beige Phenotype in White Adipose Tissue of Adult Mice by Mild Resveratrol and Nicotinamide Riboside Supplementations in Early Postnatal Life

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