β‐Carbonylamides in peptide chemistry. I. Optical rotatory properties of N‐acetoacetyl amino acids

Abstract

SynopsisThe Cotton effects of N-aceBoacety1 amino acids and derivatives were examined by a circular dichroism technique. A correlation has been established between the sign of the Cotton effect and the absolute configuration of the asymmetric center. The L derivatives show, in dioxane, negative circular dichroism curves, whereas the D antipodes present positive curves. The effect of solvent and pH and influence of alkylation a t the amide nitrogen are also discussed.