β-Carbon stereoselectivity of N -carbamoyl- d -α-amino acid amidohydrolase for α,β-diastereomeric amino acids

Practical Stereoselective Synthesis of β-Branched α-Amino Acids through Efficient Kinetic Resolution in the Phase-Transfer-Catalyzed Asymmetric Alkylations

“…In addition, they are often encountered as components of naturally occurring peptides with unique biological activities . Accordingly, numerous studies have been made for the synthesis of the individual stereoisomer of β-alkyl-α-amino acids (Figure ), most of which rely on the diastereoselective transformations involving substrates with chiral auxiliaries 3 or resolution of racemates . Hence, to our knowledge, the catalytic asymmetric approach toward this subject has been restricted to only two examples recently reported.…”