β-carboline alkaloids in Picrasma quassioides and their chemotaxonomic significance

The Progress in Pictet‐Spengler β‐Carboline Synthesis under Green Conditions

“…[2] β-Carboline scaffold is distributed widely in nature. Examples include seeds [3] and fruits [4] of Peganum harmala L, roots of Psammosilene tunicoides, [5] Evodiae fructus herb, [6] Picrasma quassioides, [7] Vochysia divergens, [8] marine sponge Hyritos reticulatus, [9] marine tunicate Cnemidocarpa stolonifera, [10] and marine bryozoan Pterocella vesiculosa. [11] Owing to their important biological activities, [12] many of these alkaloids were also prepared synthetically.…”

Divergent total syntheses of ITHQ-type bis-β-carboline alkaloids by regio-selective formal aza-[4 + 2] cycloaddition and late-stage C–H functionalization

“…b-Carboline alkaloids widely exist in a variety of animals 1 and plants. 2 These alkaloids have been discovered to possess diverse biological activities, such as anti-cancer, anti-inammatory, and anti-malaria. 3 Since the 1980s, a large number of bis-bcarboline alkaloids have been isolated by Ohmoto, [4][5][6][7][8][9][10][11][12][13][14][15][16][17] Yao, [18][19][20][21] Song, 22 Tian 23 et al from plants of the Simaroubaceae family.…”

“…20 Most of these ITHQ-type bis-b-carboline alkaloids show cytotoxic bioactivity. In 2015, Lin and coworkers reported the cytotoxicity and antibacterial bioactivities of picrasidines G (1), S (2), and F. 24 Picrasidine F shows selective cytotoxicity against the HeLa cancer cell line (IC 50 = 16.65 mM) compared to the MKN-28 (IC 50 = 145.50 mM) and B-16 (IC 50 = 95.48 mM) cancer cell lines, while picrasidines G (1) and S (2) show cytotoxicity against all three cancer cell lines (IC 50 = 4.95-19.00 mM). These three alkaloids also show antibacterial bioactivity against MRSA P0172, MRSA H0117, MSSA P0171 and MSSA H0180 (MIC = 4-16 mg mL −1 ).…”