β-Carboline alkaloids from Picrasma quassioides and their 3D-QSAR study on anti-inflammation in LPS-induced RAW 264.7 cells

Dai, Pengyu; Chen, Simin; Wang, Meiqi; Ma, Hongwen; Liu, Fangle; Chen, Lin; Zhu, Chenchen

doi:10.1016/j.fitote.2023.105437

Cited by 4 publications

(3 citation statements)

References 35 publications

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“…Another member of the Indole alkaloids is β-carboline. By 3D-QSAR, several derivates were designed [62] and evaluated regarding the immunomodulatory effect in macrophages RAW 264.7, and the relationship between the chemical structure and anti-inflammatory impact was shown in several derivates by inhibiting nitric oxide (NO) production. NO is crucial for the proper functioning of macrophages.…”

Section: Chemical Modificationmentioning

confidence: 99%

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Quantitative Structure-Activity Relationship of Alkaloids with Immunomodulatory Effects

CONTRERAS ENCINAS,

GALVEZ RUIZ,

DIAZ CHAVEZ

et al. 2024

Preprint

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Natural products are considered an essential source of chemical compounds with relevant biological activities. Important antibiotics, anti-virals, and anticancer agents within healthcare facilities have been isolated from them. In recent decades, the study of alkaloids and the modulation of the immune response has aroused interest. The survey of SAR alkaloids with immunomodulatory effects is of great importance since structural modifications impact the effectiveness of the immunomodulatory activity, thus promoting the rational design of more effective and specific drugs. This review exhibits the main alkaloids with an immunomodulatory effect and their relationship with SAR studies, particularly in activating leukocytes and secretion of molecules with critical inflammatory activities such as cytokines, chemokines, and nitric oxide. These studies optimize the properties of alkaloids and allow a deeper understanding of the mechanisms of action at a molecular level, which is fundamental for the innovation of immunological therapies.

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Section: Chemical Modificationmentioning

confidence: 99%

“…The balanced production and regulation of NO are essential for effective immune responses and maintaining tissue homeostasis. Thus, β-carboline alkaloid derivates present an attractive potential pharmacological agent with immunosuppressive potential [62].…”

Section: Chemical Modificationmentioning

confidence: 99%

Quantitative Structure-Activity Relationship of Alkaloids with Immunomodulatory Effects

CONTRERAS ENCINAS,

GALVEZ RUIZ,

DIAZ CHAVEZ

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…生物碱是一种从药用植物中筛选出的具有显著的抗炎、镇痛、抗肿瘤等作用的有效成分 [1][2][3]。目前长春碱类、紫杉醇类生物碱已被成功开发为抗癌药物 [4][5][6][7]。喜树碱是从珙桐科植物喜树果实或根中提取的萜类吲哚生物碱 [8]…”

Section: 简介unclassified

MIL-101(Fe) as a Drug Carrier of Loading Irinotecan: Experimental and Theoretical Studies

Haiwen,

Chang,

Rou

et al. 2023

cse

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Six new quassinoids from Picrasma chinese P·Y. Chen and their cytotoxicity activity

Yang,

Pu,

Chen

et al. 2024

Fitoterapia

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β-Carboline alkaloids from Picrasma quassioides and their 3D-QSAR study on anti-inflammation in LPS-induced RAW 264.7 cells

Cited by 4 publications

References 35 publications

Quantitative Structure-Activity Relationship of Alkaloids with Immunomodulatory Effects

Quantitative Structure-Activity Relationship of Alkaloids with Immunomodulatory Effects

MIL-101(Fe) as a Drug Carrier of Loading Irinotecan: Experimental and Theoretical Studies

Six new quassinoids from Picrasma chinese P·Y. Chen and their cytotoxicity activity

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