β‐blockers interfere with cell homing receptors and regulatory proteins in a model of spontaneously hypertensive rats

Eibel, Bruna; Kristochek, Melissa; Peres, Thiago Rodrigues; Dias, Lucinara Dadda; Dartora, Daniela Ravizzoni; Casali, Karina Rabello; Kalil, Renato A. K.; Lehnen, Alexandre Machado; Irigoyen, Maria Cláudia; Markoski, Melissa Medeiros

doi:10.1111/1755-5922.12434

Cited by 2 publications

(1 citation statement)

References 39 publications

(62 reference statements)

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“…Nonetheless, MetSyn is difficult to study in experimental animals because of the lack of good animal models that simultaneously express all or almost all components of the syndrome (SENAPHAN et al, 2015). Widely used in experimental studies, SHR (spontaneously hypertensive rat) is a model of genetic arterial hypertension, which resembles essential human hypertension, including the presence of glucose metabolism disorders commonly seen in essential hypertensives (EIBEL et al, 2018). However, SHR rarely become obese, whereas the various animal models of diet-induced obesity or spontaneously obese unfrequently become hypertensive (VELLOSO, 2009).…”

Section: Introductionmentioning

confidence: 99%

Effects of the Ingestion of Flaxseed (Linum Usitatissimum L.) Oil and Physical Exercise on the Body Weight, Glycemic and Lipid Profiles of a Rat Model Developed for the Study of Metabolic Syndrome

Fernandes¹,

Oltramari²,

Nardo³

et al. 2021

Rev. Cont. Saúde

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Metabolic syndrome (MetSyn) is a disorder that involves a series of symptoms that are associated to obesity and metabolic modifications, and increases the risk of developing cardiovascular disease and type 2 diabetes Mellitus. The study of new possibilities of non-drug therapies is fundamental for the primary prevention of MetSyn. The aim of this work was to evaluate the responses of spontaneously hypertensive rats (SHR) with lipid changes induced by the administration of dexamethasone (DEXA) to the ingestion of flaxseed oil associated or not associated with physical exercise regarding the body weight, and glycemic and lipid profiles, in comparison with the drug treatment with metformin. After 24 days of experiment, the 20-week-old animals were submitted to the glucose tolerance test (GTT) and lipid profile evaluation. The results showed that the administration of DEXA in SHR animals promoted a framework of hyperglycemia, dyslipidemia and attenuated the insulin resistance common in the SHR, thus producing an experimental model with several components of the human MetSyn. The effects on weight gain indicated an important preventive action of flaxseed oil and exercise on the weight evolution of SHR-DEXA animals. Furthermore, the ingestion of flaxseed oil associated or not with exercise promoted significant improvements on hyperglycemia and glucose intolerance in these animals. Regarding the lipid profile, the treatments with flaxseed oil and exercise promoted reductions in triglyceride levels and HDL-c increase; however, the combination of these two non-drug interventions was more effective than the isolated treatments.

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Section: Introductionmentioning

confidence: 99%

Effects of the Ingestion of Flaxseed (Linum Usitatissimum L.) Oil and Physical Exercise on the Body Weight, Glycemic and Lipid Profiles of a Rat Model Developed for the Study of Metabolic Syndrome

Fernandes¹,

Oltramari²,

Nardo³

et al. 2021

Rev. Cont. Saúde

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Gene therapy for refractory angina and cell therapy for heart failure: experience of a Brazilian research group

et al. 2019

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β‐blockers interfere with cell homing receptors and regulatory proteins in a model of spontaneously hypertensive rats

Abstract: β-blockers modulated tissue expression of the proteins and their interactions following 30 days of treatment. It evidences that this class of drugs can interfere with proteins of cell homing pathways.

Cited by 2 publications

References 39 publications

Effects of the Ingestion of Flaxseed (Linum Usitatissimum L.) Oil and Physical Exercise on the Body Weight, Glycemic and Lipid Profiles of a Rat Model Developed for the Study of Metabolic Syndrome

Effects of the Ingestion of Flaxseed (Linum Usitatissimum L.) Oil and Physical Exercise on the Body Weight, Glycemic and Lipid Profiles of a Rat Model Developed for the Study of Metabolic Syndrome

Gene therapy for refractory angina and cell therapy for heart failure: experience of a Brazilian research group

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