β-Blocker Use and Clinical Outcomes in Patients With COPD Following Acute Myocardial Infarction
David C. LaFon,
Erika S. Helgeson,
Sarah Lindberg
et al.
Abstract:ImportanceWhile β-blockers are associated with decreased mortality in cardiovascular disease (CVD), exacerbation-prone patients with chronic obstructive pulmonary disease (COPD) who received metoprolol in the Beta-Blockers for the Prevention of Acute Exacerbations of Chronic Obstructive Pulmonary Disease (BLOCK-COPD) trial experienced increased risk of exacerbations requiring hospitalization. However, the study excluded individuals with established indications for the drug, raising questions about the overall … Show more
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