2010
DOI: 10.4161/cc.9.19.13325
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β-Arrestin-1 links mitogenic sonic hedgehog signaling to the cell cycle exit machinery in neural precursors

Abstract: Development of the cerebellum, a brain region regulating posture and coordination, occurs post-natally and is marked by rapid proliferation of granule neuron precursors (CGNPs), stimulated by mitogenic Sonic hedgehog (Shh) signaling. β-Arrestin (βArr) proteins play important roles downstream of Smoothened, the Shh signal transducer. However, whether Shh regulates βArrs and what role they play in Shh-driven CGNP proliferation remains to be determined. Here, we report that Shh induces βArr1 accumulation and loca… Show more

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Cited by 19 publications
(26 citation statements)
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“…ESM 1b). Transcripts, such as Gli1 , that are direct targets of Gli2/3 downstream of Shh have been shown to increase rapidly at these early time points and remain elevated throughout the 48 hours of culture [46]. In contrast, we did not observe any significant changes in p38 mRNA levels with or without Shh.…”
Section: Resultscontrasting
confidence: 82%
See 1 more Smart Citation
“…ESM 1b). Transcripts, such as Gli1 , that are direct targets of Gli2/3 downstream of Shh have been shown to increase rapidly at these early time points and remain elevated throughout the 48 hours of culture [46]. In contrast, we did not observe any significant changes in p38 mRNA levels with or without Shh.…”
Section: Resultscontrasting
confidence: 82%
“…This will also be critical for developing new targeted therapies to treat medulloblastoma patients that will both increase their survival rate and ameliorate the life-long, debilitating side effects that occur as a result of the current standard of care (surgical resection, craniospinal radiation, chemotherapy). Mitogen-Activated Protein Kinases (MAPKs) play a prominent role in regulating proliferation in all mammalian cells and Shh has been noted to act very much like a classic mitogen [27,46,59]. Moreover, classic MAP/Erk kinase pathway activity is known to be required for long-term CGNP survival, albeit dispensable for short-term CGNP proliferation [6,27].…”
Section: Introductionmentioning
confidence: 99%
“…[3][4][5][6][7][8][9][10][11][12] A global proteomics analysis of b-arr1-interacting proteins demonstrated that b-arr1 interactions take place not only in the cytoplasm, but also in the nucleus, 13 suggesting that b-arr1 has a role in transcriptional regulation in different human cells. [14][15][16] Previous studies indicate that under d-or k-opioid receptor stimulations, nuclear b-arr1 specifically accumulates at p27 and c-fos promoters through scaffolding cyclic adenosine monophosphate responseelement (CRE) binding protein and histone acetyltransferase p300, thus enhancing local histone acetylation and gene transcription. 17 A similar mechanism was also observed during T-cell activation, in which nuclear b-arr1 increases Bcl-2 expression and contributes to CD4 þ T-cell survival.…”
Section: Epithelial Ovarian Cancer (Eoc) Often Features Endothelin (Ementioning
confidence: 99%
“…A global proteomic analysis also demonstrated that β-arrestin1 is distributed in the cytoplasm as well as in the nucleus [6]. These give investigators a new inspiration that β-arrestin1 plays a vital role in transcriptional regulation in cell growth, apoptosis, and modulation of immune functions [7][8][9]. Meanwhile, there are increasing evidences that nuclear β-arrestin1 contributes to tumor growth, invasion, and metastasis in multiple malignancies such as breast cancer, colorectal cancer, lung cancer, and prostate cancer [10][11][12][13].…”
Section: Introductionmentioning
confidence: 96%