β-Amyloid 25–35 and/or quinolinic acid injections into the basal forebrain of young male Fischer-344 rats: Behavioral, neurochemical and histological effects

Sigurdsson, Einar M.; Hejna, Matthew J.; Lee, J.M.; Lorens, Stanley A.

doi:10.1016/0166-4328(96)00135-0

Cited by 13 publications

(2 citation statements)

References 61 publications

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“…Conversely, other studies failed to demonstrate the neurotoxic effects of A/β in vivo (Joseph et al, 2001; Rottkamp et al, 2002). Separate injections into the hippocampus of beta amyloid 25–35 or the incubated form of beta amyloid 25–35 alone failed to significantly affect maze acquisition in the rat (Dornan et al, 1993; Sigurdsson et al, 1995). Bilateral injections of amyloid 25–35 into the amygdala of young Fischer rats can induce neuronal tau‐2 staining in the right, but not the left amygdala and hippocampus (Sigurdsson et al, 1997).…”

Section: Discussionmentioning

confidence: 99%

Potential roles of Alzheimer precursor protein A4 and β‐amyloid in survival and function of aged spinal motor neurons after axonal injury

Xie

Chai

et al. 2003

J of Neuroscience Research

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To study the potential role of Alzheimer precursor protein A4 (APP) and beta-amyloid (A/beta) on aging motor neuron survival, expression of APP, A/beta, and choline acetyltransferase (ChaT) were investigated in aged rats after either distal axotomy or root avulsion injury. Approximately 45% in number of total aged spinal motor neuron were normally APP-positive. A/beta-positive neurites were observed normally in the spinal ventral horn of aged rats. After distal axotomy, without apparent neurodegeneration such as cell loss and decreased ChaT-immunoreactivity, increased levels of APP expression were observed in the spinal cords of aged rats post-injury. In contrast, after avulsion, expression of APP and A/beta were downregulated in the spinal ventral horn of aged rats, and marked loss of spinal motor neurons and downregulated ChaT expression were observed. Our data indicate that APP and A/beta might play beneficial roles in neuronal survival of aged spinal motor neurons after axonal injury.

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Section: Discussionmentioning

confidence: 99%

Potential roles of Alzheimer precursor protein A4 and β‐amyloid in survival and function of aged spinal motor neurons after axonal injury

Xie

Chai

et al. 2003

J of Neuroscience Research

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“…After 4 weeks, the rats were euthanized by decapitation, brains were rapidly excised, hippocampi were dissected out on ice and placed in chilled NaCl solution (0.9%). [22] The hippocampi were then homogenized using a Teflon–glass homogenizer in freshly prepared 10% trichloroacetic acid (1:5 w/v) in ice cold conditions. The homogenates were centrifuged at 4°C (8000 × g ; 10 min) and the supernatant was collected and immediately used for the estimation of Ach by the fluorimetric method.…”

Section: Methodsmentioning

confidence: 99%

Acetylcholine and memory-enhancing activity of Ficus racemosa bark

Ahmed¹,

Chandra

Manjunath³

2011

Phcog Res

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Background:Alzheimer's disease (AD) is a progressive neurodegenerative disorder resulting in dementia and enhancement of acetylcholine (Ach) levels in brain using acetylcholinesterase inhibitors is one of the most important approaches for the treatment of AD.Methods:In this study, aqueous extract of Ficus racemosa Linn. (Moraceae) bark having anti-inflammatory, antioxidant, and anticholinesterase activity was evaluated for its ability to enhance Ach levels, and to ascertain its antidementia activity in rats. This work was carried out under the assumption that the F. racemosa extract may show combination of actions which could be beneficial in the treatment of AD, such as neuroprotection, attributed to antioxidant and anti-infl ammatory property and may elevate levels of Ach like Ficus hispida extract reported earlier.Results:Administration of the extract at two levels viz., 250 and 500 mg/kg signifi cantly raised (P ≤ 0.05) Ach levels in hippocampi of rats compared to control. The percentage enhancement in Ach levels was found to be 22% and 38%, respectively. Further, the extract at both dosage levels elicited signifi cant reduction (P ≤ 0.05) in transfer latency on elevated plus-maze, which was used as an exteroceptive behavioral model to evaluate memory in rats.Conclusion:It is inferred that it would be worthwhile to explore the potential of F. racemosa in the management of Alzheimer disease.

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