β-Adrenergic modulation of male sexual behavior elicited from the medial preoptic area in rats

Mallick, Hrudananda; Manchanda, Smita; Kumar, Velayudhan Mohan

doi:10.1016/0166-4328(95)00168-9

Cited by 29 publications

(12 citation statements)

References 21 publications

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“…In addition, no alterations in DA and DOPAC levels were observed in the POA of lizards expressing male-like mounting behavior, and it seems that the 5-HT system does not affect stored DA levels to elicit behavioral changes. Noradrenergic neurotransmission in the POA is known to be involved in male sexual behavior (Mallick et al, 1996), and norepinephrine and serotonin interact to influence sexual behavior in the male rat (Fernandez-Guasti et al, 1986). Recent work with C. uniparens has also shown the POA to have high levels of norepinephrine (Brian Dias and David Crews, unpublished observations), a neurotransmitter that we were unable to measure using the reported HPLC method.…”

Section: Discussionmentioning

confidence: 72%

Serotonergic modulation of male-like pseudocopulatory behavior in the parthenogenetic whiptail lizard, Cnemidophorus uniparens

Dias

Crews

2006

Hormones and Behavior

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Hormone-neurotransmitter interactions form an important link through which hormones influence a variety of behavioral processes. Typically, sexual behavior is dimorphic with males mounting receptive females. In the all-female lizard species Cnemidophorus uniparens, individuals display both male-like pseudocopulation and female-like receptivity. These respective behavioral states are correlated with high circulating concentrations of progesterone following ovulation and of estrogen preceding it. In sexual species, serotonin is involved in male-typical mounting, and, as reported here, in male-like pseudosexual behavior in this unisexual species. In the first study, C. uniparens were ovariectomized and treated systemically with exogenous androgen, a hormonal regimen that results in individuals displaying only male-like pseudosexual behavior. An increase in serotonin levels in the preoptic area coupled with the suppression of male-like pseudocopulation was observed in androgen-treated lizards injected with 5-hydroxytryptophan (the precursor of serotonin) and clorgyline (a monoamine oxidase inhibitor) compared to vehicle-treated controls. Our second experiment involved ovariectomizing lizards and either injecting them with estradiol or implanting them with either an empty (Blank) or a progesterone-or testosterone-containing Silastic capsule. Treatment with para-chlorophenylalanine (an inhibitor of tryptophan hydroxylase) facilitated malelike pseudosexual behavior depending on the circulating hormonal milieu and decreased serotonin levels in the preoptic area. Our data suggest that serotonin is inhibitory to male-like pseudosexual behavior in C. uniparens but more importantly that the hormonal environment modulates the serotonin system at the level of the preoptic area, with the serotonergic system then establishing behavioral thresholds that allow for this behavior to be "gated".

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Section: Discussionmentioning

confidence: 72%

Serotonergic modulation of male-like pseudocopulatory behavior in the parthenogenetic whiptail lizard, Cnemidophorus uniparens

Dias

Crews

2006

Hormones and Behavior

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“…The male rats were placed in a compartment with receptive females to assess male sexual function. Bilaterally ovariectomized females of the same strain, primed with 25 lg estradiol benzoate, followed (48 h later) by injection of 1 mg of progesterone, were used as receptive females in these studies [44].…”

Section: Methodological Considerationsmentioning

confidence: 99%

“…*P < 0.05, **P < 0.01 significance for time spent in the particular compartment compared to aCSF recordings. P < 0.05, à P < 0.01 significance for wake period compared to aCSF recordings behavior [44]. The b receptor blockers, when applied into the mPOA, did not produce any alteration in S-W, though it suppressed the male sexual behavior [40,44].…”

Section: Effect Of Sexual Behavior On S-wmentioning

confidence: 99%

“…P < 0.05, à P < 0.01 significance for wake period compared to aCSF recordings behavior [44]. The b receptor blockers, when applied into the mPOA, did not produce any alteration in S-W, though it suppressed the male sexual behavior [40,44]. On the other hand, application of b adrenergic agonist at the POA produced arousal [49].…”

Section: Effect Of Sexual Behavior On S-wmentioning

confidence: 99%

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Alpha-1 Adrenergic Receptors in the Medial Preoptic Area are Involved in the Induction of Sleep

2006

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This paper reviews the recent studies that led to the conclusion that the noradrenergic neurons projecting to the medial preoptic area (mPOA) are hypnogenic and that they mediate this action through alpha(1) adrenergic receptors. Microinjection of noradrenaline (NA) into the mPOA induced arousal. Studies using alpha(2) adrenergic drugs showed that the arousal induced by intrapreoptic injection of NA was due to its action on presynaptic alpha(2) adrenergic receptors. A combination of lesion and chemical stimulation techniques demonstrated that when NA acted on the postsynaptic alpha(1 )receptors in the mPOA, it induced sleep. Intrapreoptic injection of alpha(1) agonist, methoxamine could induce sleep, when the hypothermia, which was simultaneously produced, was behaviorally compensated for by the animal. Increased arousal produced by the destruction of noradrenergic fibers in the mPOA further confirmed the hypnogenic role of these fibers.

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“…Also the intercopulatory interval and the postejaculatory interval were decreased. In addition, noradrenaline has a stimulatory effect on number of intromissions, without affecting the number of mounts (Mallick et al, 1996). Those stimulatory effects were most likely not caused by the α 2 -adrenoceptors, since the selective agonist clonidine actually increased the ejaculation latency and intercopulatory interval (Clark, 1991).…”

Section: Medial Preoptic Areamentioning

confidence: 98%

The role of adrenoceptors in the central nervous system in male and female rat sexual behavior

Snoeren

2015

European Journal of Pharmacology

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Three different phases can be distinguished in rats' sexual cycle, the introductory (precopulatory), the copulatory and the executive (ejaculatory) phases. In this review, a new analysis of existing pharmacological data is made, both in male and female rats, in which the different aspects of sexual behavior are taken into account. An effort is made to distinguish pharmacological effects on sexual behavior from a possible physiological role of noradrenaline. In addition, new data on the role of α2-adrenoceptors on female sexual behavior is presented. The new analysis suggests that noradrenaline has a stimulatory role on the executive phase of male sexual behavior, while the introductory and copulatory phases remain unaffected. Adrenoceptors play a role in the regulation of sexual behavior in the medial preoptic area and the lateral septum. In female rats, noradrenaline also does not play a vital role in the introductory phase. Only the lordosis behavior of the copulatory phase is sometimes affected by adrenergic agents, but only under a certain hormonal condition. The medial preoptic area, the ventromedial nucleus, the arcuate ventromedial nucleus and median eminence are involved in the regulation of female sexual behavior. The new data suggest that α2-adrenoceptors play no major role on any indices of female sexual behavior.

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β-Adrenergic modulation of male sexual behavior elicited from the medial preoptic area in rats

Cited by 29 publications

References 21 publications

Serotonergic modulation of male-like pseudocopulatory behavior in the parthenogenetic whiptail lizard, Cnemidophorus uniparens

Serotonergic modulation of male-like pseudocopulatory behavior in the parthenogenetic whiptail lizard, Cnemidophorus uniparens

Alpha-1 Adrenergic Receptors in the Medial Preoptic Area are Involved in the Induction of Sleep

The role of adrenoceptors in the central nervous system in male and female rat sexual behavior

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