β-Adrenergic blockade for the treatment of hyperthyroidism

Geffner, David L.; Hershman, Jerome M.

doi:10.1016/0002-9343(92)90681-z

Cited by 148 publications

(54 citation statements)

References 107 publications

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“…The mechanism of action of ␤-blockers in hyperthyroidism is unclear, but principally appears to antagonize overstimulated ␤-AR-mediated signaling. Interestingly, the Ca 2ϩ -lowering effect of propranolol (nonselective ␤-blocker) was proposed to be caused by a direct effect on bone or renal Ca 2ϩ handling (40). In conclusion, the present study demonstrates that dobutamine, a ␤1-AR agonist, stimulates TRPV5 activity via a PKAdependent pathway.…”

Section: Discussionmentioning

confidence: 53%

“…Hence, potential calciotropic effects of ␤-blockers might further increase chances of developing hypocalcemia in these patients. In addition, ␤-blockers are used to resolve hypercalcemia among other symptoms in hyperthyroidism (39,40). The mechanism of action of ␤-blockers in hyperthyroidism is unclear, but principally appears to antagonize overstimulated ␤-AR-mediated signaling.…”

Section: Discussionmentioning

confidence: 99%

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β1-Adrenergic Receptor Signaling Activates the Epithelial Calcium Channel, Transient Receptor Potential Vanilloid Type 5 (TRPV5), via the Protein Kinase A Pathway

Hagen¹,

Tudpor²,

Verkaart

et al. 2014

Journal of Biological Chemistry

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Background: ␤1-Adrenergic receptors (␤-ARs) are expressed in the distal part of the nephron where TRPV5-mediated active Ca 2ϩ reabsorption takes place. Results: The ␤1-AR agonist dobutamine, by inducing PKA-dependent phosphorylation, enhanced influx of Ca 2ϩ through TRPV5. Conclusion: ␤1-AR signaling potentially stimulates transcellular Ca 2ϩ transport in the kidney. Significance: Dobutamine, generally used as a positive inotrope, probably also has a calciotropic effect.

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Section: Discussionmentioning

confidence: 53%

Section: Discussionmentioning

confidence: 99%

β1-Adrenergic Receptor Signaling Activates the Epithelial Calcium Channel, Transient Receptor Potential Vanilloid Type 5 (TRPV5), via the Protein Kinase A Pathway

Hagen¹,

Tudpor²,

Verkaart

et al. 2014

Journal of Biological Chemistry

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“…The main predictors of heart failure in thyrotoxicosis are free T3 level before treatment, systolic blood pressure, and dilation of left ventricle and to a lesser extent of other heart chambers (13) . Persistent euthyroid state is the most important management of thyrotoxic cardiomyopathy.However, long duration and older age of manifestation are associated with worse prognosis.The initial managementis volume overload reduction with loop diuretics.β-blockersare used for thyrotoxic symptoms alleviation (14) and amiodarone is used in atrial fibrillation treatment (15) .…”

Section: Discussionmentioning

confidence: 99%

Graves Disease Induced Dilated Cardiomyopathy

Al‐Sadawi¹

2016

jmscr

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“…The clinical manifestations of thyrotoxicosis are usually mild, compared with other causes of hyperthyroidism, and it is self-limiting (lasting two to six weeks) (2). Therefore, treatment with beta-blockers is recommended only for symptomatic patients (3). Antithyroid drugs, which inhibit the production of new T 4 are not indicated in the management of patients with hyperthyroidism because symptoms are caused by the release of preformed T 3 and T 4 from the damaged gland (4).…”

mentioning

confidence: 99%

Painless thyroiditis associated to thyroid carcinoma: role of initial ultrasonography evaluation

Valentini

Macedo

Izquierdo

et al. 2016

Arch. Endocrinol. Metab.

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Even though it is a rare event, most associations of thyroid carcinoma with subacute thyroiditis described in the literature are related to its granulomatous form (Quervain's thyroiditis). We present a patient with subacute lymphocytic thyroiditis (painless thyroiditis) and papillary thyroid cancer that was first suspected in an initial ultrasound evaluation. A 30-year old female patient who was referred to the emergency room due to hyperthyroidism symptoms was diagnosed with painless thyroiditis established by physical examination and laboratory findings. With the presence of a palpable painless thyroid nodule an ultrasound was prescribed and the images revealed a suspicious thyroid nodule, microcalcification focus in the heterogeneous thyroid parenquima and cervical lymphadenopathy. Fine needle aspiration biopsy was taken from this nodule; cytology was assessed for compatibility with papillary thyroid carcinoma. Postsurgical pathology evaluation showed a multicentric papillary carcinoma and lymphocytic infiltration. Subacute thyroiditis, regardless of type, may produce transitory ultrasound changes that obscure the coexistence of papillary carcinoma. Due to this, initial thyroid ultrasound evaluation should be delayed until clinical recovery. We recommended a thyroid ultrasound exam for initial evaluation of painless thyroiditis, particularly in patients with palpable thyroid nodule. Further cytological examination is recommended in cases presenting with suspect thyroid nodule and/or non-nodular hypoechoic (> 1 cm) or heterogeneous areas with microcalcification focus. Arch Endocrinol Metab. 2016;60(2):178-82

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β-Adrenergic blockade for the treatment of hyperthyroidism

Cited by 148 publications

References 107 publications

β1-Adrenergic Receptor Signaling Activates the Epithelial Calcium Channel, Transient Receptor Potential Vanilloid Type 5 (TRPV5), via the Protein Kinase A Pathway

β1-Adrenergic Receptor Signaling Activates the Epithelial Calcium Channel, Transient Receptor Potential Vanilloid Type 5 (TRPV5), via the Protein Kinase A Pathway

Graves Disease Induced Dilated Cardiomyopathy

Painless thyroiditis associated to thyroid carcinoma: role of initial ultrasonography evaluation

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